Susceptibility Factors of Stomach for SARS-CoV-2 and Treatment Implication of Mucosal Protective Agent in COVID-19Medicine Published on 2021-01-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome agent analyzed average blockade coronavirus coronavirus disease COVID-19 diarrhea distribution eight Enterocyte epidemiological expressed expression Factor FIVE gel Genes GI symptom GI symptoms H pylori infection Helicobacter pylori Hospital stay hospitalized patient Infection initial intestinal intestinal metaplasia intestine investigated laboratory data material mucosa mucosal Patient Protective SARS-CoV-2 SARS-CoV-2 transmission Seven significant difference Single-cell RNA sequencing stomach susceptibility Symptom tablets the SARS-CoV-2 therapy TMPRSS2 two groups [DOI] 10.3389/fmed.2020.597967 PMC 바로가기 [Article Type] Medicine
Changes in the concentration of air pollutants before and after the COVID-19 blockade period and their correlation with vegetation coverageResearch Article Published on 2021-01-142022-10-31 Journal: Environmental science and pollution research inter [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval activities addition Air pollution Air quality Analysis Area atmospheric average blockade cause change Characteristics China Concentration condition correlation correlation coefficient country Coverage COVID-19 difference dropped implementation increase in index Intervention less Linear regression Local lockdown Measures negative correlation Northeast China Pearson correlation coefficient Perspective provided Quantitative reduce reduced Region regions Seven spread of COVID-19 vegetation Vegetation cover was used [DOI] 10.1007/s11356-020-12164-2 PMC 바로가기 [Article Type] Research Article
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study퀘르세틴, 코로나19 유발 급성 신장 손상 치료제로서의 가능성: 네트워크 약리학 및 분자 도킹 연구 기반Research Article Published on 2021-01-142022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] 3CL ACE2 Activation active site active sites acute kidney Acute kidney injury AKI apoptosis-related signaling pathway apoptosis-related signaling pathways binding blockade Cell Chronic kidney disease CKD clinical setting contribute Critical develop effective function functions high mortality Infection Inflammatory inhibition inhibitor Injury Interaction investigated kidney Kidney disease kidneys life cycle mechanism molecular docking network pharmacology patients with SARS-CoV-2 Potential treatment protease PROTECT protective effect Protein quercetin renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease signaling pathways specific treatment target targets therapeutic therapeutic agent transition Viral viral life cycle [DOI] 10.1371/journal.pone.0245209 PMC 바로가기 [Article Type] Research Article
Policy Responses to the COVID-19 Pandemic in VietnamReview Published on 2021-01-112022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] agency average blockade Combination Community coronavirus country COVID-19 COVID-19 in Vietnam COVID-19 pandemic drastic eight Factors globe group Health Local Measures National Occurrence outbreak pandemic pandemic in Vietnam per day Policy policy documents policy measures policy responses policy tools response responses Schools social isolation study period Vietnam [DOI] 10.3390/ijerph18020559 PMC 바로가기 [Article Type] Review
Interleukin-6 receptor blockade with subcutaneous tocilizumab improves coagulation activity in patients with COVID-19피하 토실리주맙을 사용한 인터루킨-6 수용체 차단은 COVID-19 환자의 응고 활성을 개선합니다Article Published on 2021-01-012022-09-12 Journal: European journal of internal medicine [Category] 진단, [키워드] 95% confidence interval 95%CI activate activated Admission age Analysis Anticoagulants blockade Blood coagulation C-reactive protein change Coagulation Coagulation parameters contribute COVID-19 COVID-19 pathogenesis COVID-19 patient Critical cytokine D-dimer level death develop dose enrolled evaluate the effect fibrinogen humanized monoclonal antibody hypercoagulable hyperinflammation Hyperinflammatory IMPROVE increase in Inflammation interleukin-6 interleukin-6 receptor interquartile range laboratory-confirmed moderate occurred Occurrence parameter Patient patients with COVID-19 Platelet Pneumonia Prophylactic Prophylaxis Prothrombin time receiving receptor reduction reduction in Respiratory function Standard of care Subcutaneous subcutaneous dose sustained therapeutic thromboembolic complications Thromboprophylaxis thrombosis Tocilizumab Treatment were measured [DOI] 10.1016/j.ejim.2020.10.020 PMC 바로가기 [Article Type] Article
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromesCOVID-19 폭풍우를 이겨내기: 혈액학적 사이토카인 증후군의 교훈Review Published on 2021-01-012022-09-11 Journal: Blood reviews [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] acute respiratory syndrome attenuation blockade CAR-T CAR-T cell therapy Cell Cell signaling Cell therapy Clinical features clinical trial clinical trials coronavirus COVID-19 CRS CSS cytokine cytokine level cytokine levels Cytokine release syndrome Cytokine storm syndrome cytokine syndrome Cytokines develop Diagnosis Diagnostic Criteria disease Evidence foundation hematologic hematological hemophagocytic lymphohistiocytosis idiopathic Idiopathic multicentric Castleman disease Inflammation inhibiting lesson marker multi-organ dysfunction novel Pathogenesis Patient Release respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus −2 (SARS-CoV-2). severe COVID-19 sHLH signaling pathway storm subset Treatment [DOI] 10.1016/j.blre.2020.100707 PMC 바로가기 [Article Type] Review
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial
Interleukin-6 blockade with tocilizumab in COVID-19: Does it live up to its hype?COVID-19에서 토실리주맙을 사용한 인터루킨-6 차단: 과대 광고에 부응합니까?Comment Published on 2021-01-012022-09-12 Journal: Pulmonology [Category] MERS, SARS, 진단, [키워드] blockade Tocilizumab [DOI] 10.1016/j.pulmoe.2020.10.004 PMC 바로가기 [Article Type] Comment
Safety, tolerability, and outcomes of losartan use in patients hospitalized with SARS-CoV-2 infection: A feasibility studyResearch Article Published on 2020-12-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury adverse event AKI blockade Clinical outcome Cohort COVID-19 criteria de novo discharged Enrollment exclusion criteria feasibility hospital hospitalized patient hyperkalemia hypertension ICU admission include inclusion criteria Inflammatory marker inflammatory markers losartan maintain majority mechanical ventilation MOST Nasopharyngeal swab occurred outcome outcomes parameter Patient patients patients hospitalized PCR pilot study polymerase chain positive Prospective prospective cohort Prospective Study provide randomized clinical trials recruitment required retrospective retrospective cohort retrospective cohorts Safety SARS-CoV-2 screened significant changes in single center supplemental oxygen System Tolerability transaminitis with COVID-19 [DOI] 10.1371/journal.pone.0244708 PMC 바로가기 [Article Type] Research Article
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion콜레스테롤 25-수산화효소는 막 융합을 차단하여 SARS-CoV-2 복제를 억제합니다530 Published on 2020-12-152022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alleviate Antiviral antiviral activities antiviral activity antiviral response approach blockade catalyzed caused CH25H chimeric cholesterol Clinical treatment coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 deaths drug Drug administration effective effective vaccine Effective vaccines etiological agent food germline help highlight identify inhibit SARS-CoV-2 inhibitors of SARS-CoV-2 Innate immunity interferon late endosome late endosomes mechanism membrane fusion molecular basis pathogenicity produced Replication respiratory restrict Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 spike protein Significance Spike protein stomatitis supportive therapies supportive therapy suppresse Symptoms tested therapeutic Vaccine vesicular stomatitis vesicular stomatitis virus virus entry viruses [DOI] 10.1073/pnas.2012197117 PMC 바로가기 [Article Type] 530