Trajectories of eating behavior during COVID-19 lockdown: Longitudinal analyses of 22,374 adultsOriginal Article Published on 2021-04-012022-11-01 Journal: Clinical nutrition ESPEN [Category] Coronavirus, MERS, SARS, [키워드] Analysis analyzed changes in Chronic diseases class COVID-19 COVID-19 pandemic Covid-19 social study depressive symptom eating behavior effort events Exploratory analysis Factor finding FIVE greater highlight identify implementation Latent less lockdown longitudinal majority Measures mental health multinomial regression pandemic Pandemics participant Prevent Psychological public health Result risk factor secondary suggested Support Trajectories trajectory UCL was used [DOI] 10.1016/j.clnesp.2021.01.046 PMC 바로가기 [Article Type] Original Article
Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challengesCOVID-19 팬데믹 이후의 약물 개발: 현재 및 미래의 글로벌 건강 문제를 해결하기 위한 더 나은 시스템으로Article Published on 2021-04-012022-08-31 Journal: Expert opinion on drug discovery [Category] MERS, SARS, 신약개발, [키워드] Accessibility agency Alzheimer’s disease Area Cancer class clinical trials Clinicians COVID-19 develop disease disease-associated Diseases Drug development Drug discovery drug failure ecosystem effective effective drugs expert Fair Frame generate Health Infectious diseases knowledge malaria Medicine Medicines molecular mechanism multi overcome pace rare diseases Research research and development resources risk Safe Scientific community Time frame [DOI] 10.1080/17460441.2021.1854221 PMC 바로가기 [Article Type] Article
How the COVID-19 Pandemic Impacted Medical Education during the Last Year of Medical School: A Class SurveyArticle Published on 2021-03-302022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] addition administration affected America Analysis analyzed approach asked Care changed class COVID-19 COVID-19 pandemic cross-sectional e-learning education effective expressed Factor Google Health hospital impacted indicated Jacob knowledge Last limitations lockdown medical education Medicine modify novel coronavirus disease Novel coronavirus disease 2019 obstetrics organized pandemic Perspective platform question recommendation response Result Satisfaction School social distancing student submitted supported survey tele-education telehealth Telemedicine the United State United State university USA Year [DOI] 10.3390/life11040294 PMC 바로가기 [Article Type] Article
Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics고 처리량 스크리닝 데이터베이스의 마이닝은 COVID-19 치료제의 잠재적 표적으로서 AP-1 및 자가포식 경로를 나타냅니다Article Published on 2021-03-242022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] addition Anti-SARS-CoV-2 Activity Antiviral AP-1 approved approved drug approved drugs autophagy autophagy pathway Candidates caused class coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 therapeutics CPE Cytopathic effect Data mining database drug drug activity drug library effective effort global pandemic High-throughput screening Hope house human clinical trials in vivo mechanism New coronavirus new coronavirus SARS-CoV-2 phenotypic Potential treatment potential treatments profile pursuit reveal SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly target Target identification therapeutic Viral [DOI] 10.1038/s41598-021-86110-8 PMC 바로가기 [Article Type] Article
Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools스위스 취리히 주의 학교 아동에서 SARS-CoV-2 혈청 유병률의 클러스터링 및 종단적 변화: 55개 학교의 전향적 코호트 연구Article Published on 2021-03-172022-09-11 Journal: The BMJ [Category] Fulltext, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age children class Clustering cohort study Community community transmission coronavirus credible interval determine diagnosed District Europe explained Health highest increase in Keeping logistic regression models longitudinal change longitudinal changes moderate no significant differences occurred outcome pandemic parent parents participated preventive measure Prospective prospective cohort study provided questionnaire Questionnaires Randomly reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 seroprevalence School Schools second wave selected serological result serological results Serological testing serology serology test serology tests seronegative seropositive Seropositivity Seroprevalence severe acute respiratory syndrome Coronavirus significant difference Sociodemographic stratified summer Switzerland Symptom the SARS-CoV-2 transmission of SARS-CoV-2 Uncertainty variance variants of SARS-CoV-2 [DOI] 10.1136/bmj.n616 PMC 바로가기 [Article Type] Article
Class of 2020 in Poland: Students’ Mental Health during the COVID-19 Outbreak in an Academic SettingArticle Published on 2021-03-112022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Analysis caused class collected concerning contributed correlation COVID-19 COVID-19 pandemic demographical variable distress Efficiency Factors female Intervention lockdowns manifested mental health negative online learning P -value pandemic participant Poland Protective provide Psychopathology recommendation regression analysis relationship setting Sex students Symptom variable variables was tested was used worsened [DOI] 10.3390/ijerph18062884 PMC 바로가기 [Article Type] Article
An open label trial of anakinra to prevent respiratory failure in COVID-19COVID-19에서 호흡 부전을 예방하기 위한 아나킨라의 공개 라벨 시험Clinical Trial Published on 2021-03-082022-08-13 Journal: eLife [Category] SARS, 바이오마커, 임상, [키워드] 30-Day mortality 95% CI Administering Anakinra antagonists approach Arthritis assigned balance Biomarker blood protein blood sample Care cause circulating class clinical Combination COVID-19 COVID-19 patients death rate death rates decrease defined develop drug effective examined form framework funding hazard ratio help highest Horizon Human identify immune function immune response immune system IMPROVE incidence individual infected individual Infection Inflammation Inflammatory Inflammatory mediators injection interleukin-10 investigated less marker medication medications non-invasive ventilation once daily open label outcome Pain Patient Pneumonia Prevent Primary outcome progressed progression Protein receptor reduce reduced respiratory Respiratory failure respiratory ratio respond restored rheumatoid arthritis risk risk of death Safe SARS-CoV-2 SARS-CoV-2 virus secondary outcome Sepsis severe respiratory failure Side effects significantly SOFA SOFA score soluble urokinase plasminogen activator receptor SRF suggested suPAR Swedish Orphan Biovitrum swelling the SARS-CoV-2 virus treat treating COVID-19 patient Treatment Trial ventilator while WHO-CPS [DOI] 10.7554/eLife.66125 PMC 바로가기 [Article Type] Clinical Trial
Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responsesArticle Published on 2021-02-262022-10-04 Journal: Scientific Reports [Category] MERS, 진단, [키워드] acute respiratory syndrome allergen allergens applied approach approaches Aspergillus fumigatus association bioinformatics class cohorts complementary Computational biology and bioinformatics Coronavirus-2 COVID-19 cross-reactive cross-reactivity de novo epitope Epitopes functional Heterologous homologous immune response immunology in silico investigated involved MHC MHC class outbreak overlapping peptide peptides Phleum predicted Probability Protein proteome public health emergency responses risk factor SARS-CoV-2 sequence T cell epitope T cell epitopes the SARS-CoV-2 [DOI] 10.1038/s41598-021-84320-8 PMC 바로가기 [Article Type] Article
Phenotypes and Subphenotypes of Patients With COVID-19: A Latent Class Modeling AnalysisResearch article Published on 2021-02-262022-10-05 Journal: Chest [Category] 바이오마커, [키워드] Analysis analyzed assist association Basic science Biomarker Blood class Cleveland clinic Clinical outcome clinical trial clinical trials Cluster Comorbidities Concordance COVID-19 COVID-19 phenotype COVID-19 symptom database death demographics elevated evaluated help heterogeneity hospital Hospital admission Hospitalization hospitalized patient hospitalized patients Hyperinflammatory ICU identifying independent investigated investigator kidney dysfunction laboratory-confirmed SARS-CoV-2 infection Latent latent class latent class analysis lymphopenic modeling Mortality Patient patients patients with COVID-19 phenotype Phenotypes phenotypic Platelet positive predict presenting presenting symptoms profile Research researcher Result significantly stratified subphenotypes Symptoms System transfer translational WBC [DOI] 10.1016/j.chest.2021.01.057 [Article Type] Research article
Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19Immunology Published on 2021-02-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] accompanied acute respiratory syndrome age allele Analysis application AUC Cell characteristic class Cohort connection contributed coronavirus Course COVID-19 Critical death deaths Deceased died Elderly patient Genotype genotypes high risk HLA HLA class I HLA-A HLA-B HLA-C homozygote human leukocyte antigen immune response independent manuscript MHC class I Next-generation sequencing Patient patients with COVID-19 peptide peptide presentation presenting resulting risk ROC Russia SARS-CoV-2 severity significantly higher Spanish patient T cells the disease two group viral infection viral peptide Volunteer [DOI] 10.3389/fimmu.2021.641900 PMC 바로가기 [Article Type] Immunology