Strategies for the Production of Soluble Interferon-Alpha Consensus and Potential Application in Arboviruses and SARS-CoV-2Article Published on 2021-05-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Alpha Amino acid analyzed Antiviral Antiviral effect application approach arbovirus Arboviruses Bacteria biological activity biopharmaceutical cells Clinical use Consensus COVID-19 Culture culture media E. coli Fh8 growth Healthcare system hydrolysis IFN-α IMPROVE in vitro model Inclusion inhibit medium Potential prevalent produced Production protein sequence purified Research SARS-CoV-2 SARS-CoV-2 virus infection solubility tag Strategy susceptible temperature treat virus multiplication viruses was tested Zika [DOI] 10.3390/life11060460 PMC 바로가기 [Article Type] Article
A bivalent recombinant vaccine targeting the S1 protein induces neutralizing antibodies against both SARS‐CoV‐2 variants and wild‐type of the virusOriginal Article Published on 2021-05-172022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ACE2 binding acute respiratory syndrome antibody production Antigen AS03 B.1.351 variant bivalent vaccine Clinical use composed COVID‐19 D614G E484K effective enzyme exhibited Express hACE2 immunization immunized induce inhibiting K417N mice Mutant strains N501Y neutralization neutralizing antibody other variants pandemic protein subunit vaccine receptor‐binding domain Recombinant protein S1 subunit SARS‐CoV‐2 SARS‐CoV‐2 subunit the S1 protein transgenic mice Vaccine variant virus Virus Disease were measured [DOI] 10.1002/mco2.72 PMC 바로가기 [Article Type] Original Article
Can trace element supplementations (Cu, Se, and Zn) enhance human immunity against COVID-19 and its new variants?Review Published on 2021-05-172022-10-28 Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19, [키워드] Abstract Alter anti-inflammatory effect Antiviral available data B.1.1.7 B.1.351 Brazil Can changed Clinical data clinical study Clinical use component country COVID-19 COVID-19 infection deaths deficiency ENhance Essential trace elements Health human health Human immune system human immunity immune defense immune dysfunction immune system micronutrients Mutation New strains other variants Outpatient P.1 pandemic reliability SARS-CoV-2 South Africa strain Strains susceptibility Trace element Vaccine Vaccines viral infections virus [DOI] 10.1186/s43088-021-00123-w PMC 바로가기 [Article Type] Review
SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms면역 저하된 숙주에서 SARS-CoV-2 진화는 공유된 중화 탈출 메커니즘을 보여줍니다Article Published on 2021-05-132022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Affinity maturation antibody Antibody neutralization Antibody Response circulating Clinical use convalescent COVID-19 Critical domain Donor Efficacy Evolution globe healthy Host Immunocompromised Immunocompromised host immunoglobulins implication individual mechanism monoclonal antibodies monoclonal antibody Mutation neutralization neutralization breadth neutralization escape Neutralizing antibodies polyclonal predict Protein pseudotype RBD resistance responses reveal S variant SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody serum immunoglobulin Structure tested variant variants variants of concern Viral viral spike virus Virus evolution wild-type virus [DOI] 10.1016/j.cell.2021.03.027 PMC 바로가기 [Article Type] Article
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다Research Article Published on 2021-05-122022-09-12 Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread [DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article
Protocols for clinical use at Nature Protocols Editorial Published on 2021-05-112022-10-05 Journal: Nature protocols [Category] 임상, [키워드] Clinical use Nature [DOI] 10.1038/s41596-021-00557-7 [Article Type] Editorial
Clinical applications for exosomes: Are we there yet?Review Article Published on 2021-05-032022-10-28 Journal: British Journal of Pharmacology [Category] Coronavirus, MERS, SARS, [키워드] approach Biomarker Cancer carrier clinical clinical development clinical trials Clinical use cross diagnostic diagnostic biomarker disease Efficacy Exosome extracellular vesicle functional protein good manufacturing practice Health immunomodulation Infectious diseases Inflammation limitation Liposome manufacturing metabolites nucleic acids physiological reduced Research subset therapeutic therapeutic agents therapeutic purposes Therapeutics Transport Viral vector [DOI] 10.1111/bph.15432 PMC 바로가기 [Article Type] Review Article
Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kineticsCOVID-19 환자에 대한 하이드록시클로로퀸 사용 경험: 바이러스 부하 및 사이토카인 동역학에 대한 관점Article Published on 2021-05-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료기술, 치료제, [키워드] active against Anti-inflammatory anti-inflammatory effect Antiviral approved checked Clinical use Complication coronavirus Course COVID-19 COVID-19 diagnosis cytokine cytokine profile detectable disease status Elevation experience HCQ Hydroxychloroquine IL-17 Infection Inflammatory interferon Interferon-gamma interleukin marker Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 MONITOR Patient patients performed Perspective potential therapeutic target preliminary report Prolonged receiving remained respiratory specimen respiratory specimens SARS-CoV-2 SARS-CoV2 specific treatment symptom onset the mean treated Treatment use of hydroxychloroquine Viral load virus [DOI] 10.1016/j.jfma.2020.08.022 PMC 바로가기 [Article Type] Article
Frontline Screening for SARS-CoV-2 Infection at Emergency Department Admission by Third Generation Rapid Antigen Test: Can We Spare RT-qPCR?3세대 신속 항원 검사를 통한 응급실 입원 시 SARS-CoV-2 감염에 대한 최전선 검사: RT-qPCR을 절약할 수 있습니까?Article Published on 2021-05-012022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] 95% CI active viral replication acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antigenic test Can Clinical use complement coronavirus country COVID-19 cycle threshold demonstrated Department Diagnosis diagnostic digital PCR droplet Emergency emergency department expected false-negative Generation genomic hospital increase infections Infectivity introduced IQR lack median Nasopharyngeal swab nasopharyngeal swabs Patient PCR persists qPCR quantification Rapid Rapid antigen tests Rapid diagnostic test respiratory risk RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA Screening sensitivity severe acute respiratory syndrome Coronavirus specificity subgenomic RNA subject suggested the WHO Viral Viral load [DOI] 10.3390/v13050818 PMC 바로가기 [Article Type] Article
Uptake of telehealth in Parkinson’s disease clinical care and research during the COVID-19 pandemicMini review Published on 2021-05-012022-10-05 Journal: Parkinsonism & Related Disorders [Category] 임상, [키워드] activity barrier Care clinical care Clinical practice clinical trial Clinical use clinician conducted coronavirus COVID-19 COVID-19 pandemic demographic data deviation disease ENhance evaluate fill out group impacted in-person visit Patient Patient care patients protocol provided remained Research responses Result synchronous technology telehealth Telemedicine uptake [DOI] 10.1016/j.parkreldis.2021.03.032 [Article Type] Mini review