Socioeconomic disparity and the risk of contracting COVID-19 in South Korea: an NHIS-COVID-19 database cohort studyResearch Article Published on 2021-01-152022-10-28 Journal: BMC Public Health [Category] COVID-19, [키워드] affected age Analysis analyzed association Cohort cohort study collected control groups coronavirus disease COVID-19 COVID-19 patient database diagnosed Final four group group higher risk highest income individual infections Korean Lower lower risk lowest multivariable logistic regression no significant differences older population prevention of COVID-19 Result risk social class South South Korea statistically Strategy study participant supplementary material was used [DOI] 10.1186/s12889-021-10207-y PMC 바로가기 [Article Type] Research Article
The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial경증 및 중등도 COVID-19 환자에서 이버멕틴의 효능 및 안전성: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, 치료제, [키워드] 1:1 ACE inhibitor ACE inhibitors acute respiratory syndrome Adverse drug reaction Adverse drug reactions AIDS allergy anticipated Anticoagulant Anticoagulants Asthma Bandar Abbas Blinding Breastfeeding Captopril chest X-ray clinical clinical symptom Clinical symptoms clinical trial clinical trials company Computed tomography Confirmed Control control group control groups Controlled trial COVID-19 COVID-19 symptom criteria Critical CXR Department discharge Diseases dissemination dose Drug allergy education Efficacy and safety element evaluate exclusion criteria FIVE France group groups history Hospital stay Hospitalization Hospitalization Mechanical ventilation hydroxychloroquine sulfate ICU admission incidence include inclusion criteria India Infection Informed consent Inpatients Interferon beta-1a intervention group Iran Ivermectin Kidney disease liver loiasis Lopinavir Lopinavir/ritonavir mechanical ventilation Mild mild COVID-19 symptom mild COVID-19 symptoms mild pneumonia Ministry of Health moderate Moderate COVID-19 moderately severe COVID-19 MSD number objective Open-label Other outcome Outpatient outpatients parallel-group participant Patient patients patients with moderate PCR pharmaceutical Pharmaceutical Company Phase 3 Pneumonia Pregnancy Primary outcome Primary outcomes protocol random randomization Randomized Randomized controlled trial receive regimen Registered registration date registration number registry respiratory Ritonavir routine care Sample size secondary outcome selected Seven Severe acute respiratory syndrome single dose single-center standard treatment status Study protocol subsequent supplementary material table the patient Treatment treatment group Trial registration twice a day two group two groups underlying diseases Version Warfarin website weight [DOI] 10.1186/s13063-020-04988-7 PMC 바로가기 [Article Type] Letter
Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: A retrospective cohort studyTanreqing Capsule이 COVID-19 환자에서 핵산의 음성 전환 시간에 미치는 영향: 후향적 코호트 연구Article Published on 2021-01-012022-08-31 Journal: Journal of integrative medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] addition Administered Capsule CD3 CD4 CD45 center Chinese clinical Clinical efficacy complement conducted control group control groups coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnostic testing COVID-19 patient COVID-19 patients diagnostic diagnostic testing disease Effect fecal hospital immune laboratory-confirmed mechanism Mild moderate Moderate COVID-19 negative Negative conversion Negative conversion rate nucleic acid pandemic Patient pharyngeal Pharyngeal swab Public reductions in retrospective cohort study Shanghai Shanghai Public Health Clinical Center Significant significant reductions statistically significant difference subset T cell T cells T-cell Tanreqing Capsule. the median Therapeutic benefit Traditional Traditional Chinese medicine treated Treatment treatment group was used [DOI] 10.1016/j.joim.2020.10.002 PMC 바로가기 [Article Type] Article
Comparison of antiviral effect for mild-to-moderate COVID-19 cases between lopinavir/ritonavir versus hydroxychloroquine: A nationwide propensity score-matched cohort study로피나비르/리토나비르 대 히드록시클로로퀸 간의 경증 내지 중등도 COVID-19 사례에 대한 항바이러스 효과 비교: 전국적인 성향 점수 일치 코호트 연구Comparative Study Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] age Analysis Antiviral effect benefit case-control study cohort study conducted control group control groups controls COVID-19 COVID-19 case determine HCQ Health Insurance Hydroxychloroquine insurance IQR Lopinavir Lopinavir/ritonavir malignancy median Mild-to-moderate Multivariate analysis National Health Insurance not significantly different old age Patient patients with COVID-19 Pneumonia prolonged viral shedding propensity score matching PSM retrospective risk factor Ritonavir SARS-CoV-2 service standard care statistically significant steroid steroid use three groups treatment groups Viral viral clearance viral shedding [DOI] 10.1016/j.ijid.2020.10.062 PMC 바로가기 [Article Type] Comparative Study
Obstacles and Considerations Related to Clinical Trial Research During the COVID-19 PandemicMedicine Published on 2020-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] affecting approvals arising article Cancer catastrophic caused clinical Clinical research clinical trial Clinical trial design clinical trials Community compassionate use Confusion control groups COVID-19 COVID-19 crisis COVID-19 pandemic Data analysis data integrity Diseases effective Efficiency effort endpoints ethical concern Ethics Factor faster feasibility flexible fraction Health help include information maintain media medications misinformation multicenter trials obstacle off-label pandemic press Prospective clinical trial raised randomization released releases remote monitoring Research SARS-CoV-2 Scientific community subject Treatment Trial urgency virus [DOI] 10.3389/fmed.2020.598038 PMC 바로가기 [Article Type] Medicine
Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort StudyArticle Published on 2020-12-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated acute illness acute respiratory distress acute respiratory syndrome Admission ARDS baseline level characterized control group control groups coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cut-off value D-dimer diagnosis of COVID-19 Disseminated intravascular coagulation Dyspnea Emergency evaluated Fever fibrinogen help Hemostasis highly pathogenic Hospital admission hospitals identify increase in induce Italian Laboratory large cohort material pandemic parameter Patient performed Physical examination Prognostic marker Prognostic value prothrombin SARS-CoV-2 sensitivity Serum level specificity statistically significant syndrome the disease value [DOI] 10.3390/jcm9124134 PMC 바로가기 [Article Type] Article
Efficacy of a web application for stress management among Iranian college students during COVID-19 outbreak: a study protocol for randomized controlled trialsCOVID-19 발생 시 이란 대학생의 스트레스 관리를 위한 웹 애플리케이션의 효능: 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2020-12-142022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] Anxiety approved assigned clinical clinical trials College student conducted control group control groups coronavirus COVID-19 COVID-19 outbreak elevated evaluate General population indicated Intervention intervention group Iran management Medical Science Medical Sciences mental health burden Mental health disorder mental health disorders Mobile health New coronavirus outbreak participant Perceived Stress Scale Prevalence prevalence of COVID-19 Primary outcome protocol provided Psychological Randomized controlled trial Randomly registry sleep quality Stress Stress management Stress Scale Study protocol Telemedicine two group two groups university web application [DOI] 10.1186/s13063-020-04949-0 PMC 바로가기 [Article Type] Study Protocol
Natural versus Recombinant Viral Antigens in SARS-CoV-2 Serology: Challenges in Optimizing Laboratory Diagnosis of COVID-19SARS-CoV-2 혈청학에서 천연 바이러스 항원 대 재조합 바이러스 항원: COVID-19에 대한 실험실 진단 최적화의 과제Original Article Published on 2020-11-262022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody Antigen assays asymptomatic patient Brazil challenge choice commercialization control groups COVID-19 COVID-19 diagnosis COVID-19 negative criteria dependent on develop Diagnosis diagnosis of COVID-19 diagnostic ELISA estimation exhibited false-negative false-negatives False-positive false-positives fraction house IgG IgG antibodies in-house ELISA in-house ELISAs infected patient infected patients Infection information International Laboratory laboratory diagnosis natural nucleocapsid protein pandemic Patient performed public health emergency qPCR recombinant Recombinant nucleocapsid protein recombinant proteins SARS-CoV-2 SARS-CoV-2 Whole Viral Antigen sera serological test serology susceptibility the SARS-CoV-2 Viral Viral antigen viral antigens [DOI] 10.6061/clinics/2020/e2290 PMC 바로가기 [Article Type] Original Article
Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19): a structured summary of a study protocol for a randomized controlled trialCOVID-19(IVERCOR-COVID19) 환자의 입원을 방지하기 위한 Ivermectin: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-11-242022-08-13 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] 1:1 acute infectious disease addition adherence administration Admission adverse event adverse events age allergy analyzed Anthropometric data antiviral drug antiviral drugs Arm ARMS assessment barrier basal blinded Breastfeeding breastfeeding women Cardiology Care care providers carried cause Chain Reaction childbearing age Chloroquine cirrhosis component components Concomitant Concomitant medication Confirmed connection contraceptive method contraceptives Control control group control groups coordination Corriente COVID-19 COVID-19 patient population criteria current Day death demographic demographic data Diagnosis diagnosis of COVID-19 dialysis discharged dissemination dose double-blind drug Efficacy Efficacy and safety elapsed element EOS Equal example exclusion criteria Final final visit first dose Follow-up greater heart rate Hospitalization hospitalizations Hydroxychloroquine incidence include Inclusion inclusion criteria inclusion/exclusion criteria Informed consent Intervention Invasive mechanical ventilation investigator investigators Ivermectin Ivermectin safety Laboratory less liver Liver cirrhosis Liver disease mal-absorptive syndrome medical history medication menstrual menstrual cycles Mortality negative Negative PCR number objective outcome outcome assessor outcome assessors over oxygen oxygen saturation parallel group participant Participants Participation Patient patients with COVID-19 PCR PCR swab Placebo placebo-controlled study polymerase chain polymerase chain reaction Polymerase chain reaction test postmenopausal pregnant Presence Prevent Primary outcome protocol Public public health randomization Randomized Randomized controlled trial randomly permuted blocks receive recommendation recorded recruitment reducing renal replacement therapy replacement therapy reproductive required Research Sample size SARS-CoV2 secondary severe liver disease single-center standard treatment standard treatment alone Study protocol supplementary material surgical Swab table Tablet temperature the patient Total Treatment Trial Trial registration use of hydroxychloroquine Version Viral viral pathology Vital vital signs vital status web system website weight woman women [DOI] 10.1186/s13063-020-04813-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2Article Published on 2020-11-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Analysis approach arachidonic acid AUC Biomarkers characterized circulating control groups coronavirus correlated COVID-19 COVID-19 patient death Degradation Effect Evidence fatty acids free fatty acids Host host response Infection key factor Lipid mechanism metabolism metabolomic metabolomics molecule New Pathogenesis pathogenesis of COVID-19 Phosphatidylcholine Phospholipase A2 plasma porphyrins potential biomarkers provide provided response Revealed SARS-CoV-2 SARS-COV-2 infection severity spread to target the disease Therapeutic strategies therapeutic target therapeutic targets Triglyceride tyrosine [DOI] 10.3390/ijms21228623 PMC 바로가기 [Article Type] Article