Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patientsResearch Published on 2022-01-282022-10-04 Journal: Critical Care [Category] SARS, 임상, [키워드] acute respiratory distress analyzed ARDS association Berlin CAPA Charité clinical parameter Cohort Corticosteroid COVID-19 COVID-19 patient COVID-19 patients criteria Critically ill Date Dexamethasone Diagnosis identify IL-6 increase in independent risk factor intensive care patient intensive care unit multivariable analysis Patient performed pulmonary aspergillosis registration number renal replacement therapy Result risk risk factor supplementary material syndrome therapy treated Treatment [DOI] 10.1186/s13054-022-03902-8 PMC 바로가기 [Article Type] Research
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
A Tale of Two Surges: Differences in Outcomes in the COVID-19 Pandemic in a Community Teaching Hospital in MassachusettsInternal Medicine Published on 2022-01-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Admission antiviral therapy both group Care CCI center Characteristics Charlson Comorbidity Index Clinical data clinical outcomes Community Comorbidity conducted coronavirus coronavirus disease Corticosteroid COVID-19 COVID-19 cases COVID-19 mortality death Dementia diabetes difference DNR English examined hospital ICU implementation independent Infection infectious disease medicine information Inpatient intensive care Lung disease Massachusett Mechanical mechanical ventilation median median age Mortality obesity outcome overall mortality pandemic Patient patients patients with COVID-19 PCR polymerase chain predicted primary endpoint Remdesivir reported required Result retrospective research SARS-CoV-2 Scientific community survival Teaching the patient Therapies Treatment Ventilation [DOI] 10.7759/cureus.21547 PMC 바로가기 [Article Type] Internal Medicine
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과Research Article Published on 2022-01-212022-09-10 Journal: eLife [Category] 변종, [키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured [DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article
Use of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19Observational Study Published on 2022-01-212022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] 95% CI appear benefit collected complications confounding factors Corticosteroid different dose doses drug elevated epidemiological evaluated evolution of patient glucocorticoid in-hospital mortality incidence increased mortality increased survival infectious complication Inflammatory marker interstitial low-dose mechanism Mortality no difference non-genomic objective observational study Patient patients patients treated Pneumonia primary endpoint radiological registry Result SARS-COV-2 infection Sepsis therapy use of corticosteroid were used with COVID-19 [DOI] 10.1371/journal.pone.0261711 PMC 바로가기 [Article Type] Observational Study
Quality of life of patients with rheumatic diseases during the COVID-19 pandemic: The biopsychosocial pathClinical Trial Published on 2022-01-182022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Administered affected age Anxiety assessment assigned baseline Care Comorbidity Corticosteroid COVID-19 COVID-19 negative DASS-21 Depression dimension dimensions disease emotional evaluated Factor Follow-up IES-R impacted information Linear regression analysis magnitude majority MOST Multiple Outpatient outpatient clinic Patient physical predicted Psychological Quality Randomly Result rheumatic disease selected significantly lower SLE social determinant Sociodemographic Sociodemographic factor trajectory [DOI] 10.1371/journal.pone.0262756 PMC 바로가기 [Article Type] Clinical Trial
Asthma Associated Cytokines Regulate the Expression of SARS-CoV-2 Receptor ACE2 in the Lung Tissue of Asthmatic PatientsImmunology Published on 2022-01-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] ACE2 ACE2 expression Affect age airway epithelium association Asthma asthmatic Asthmatic patients biopsies Cohort Corticosteroid COVID-19 cytokine Cytokines data set determine differential expression evaluate expression expression level expression of SARS-CoV-2 Factor fibroblast Gender Gene Expression groups healthy controls IFN-γ IL-13 IL-17 IL-19 IL-4 IL-8 increase increased expression Inflammation Inflammatory cytokines less lower expression lung Lung inflammation lung tissue moderate receptors regulate Regulatory risk risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 receptor severity significantly sputum subjects susceptibility the patient tissue inflammation TMPRSS2 TMPRSS2 expression TMPRSS2 expression level Treatment Type upregulated were used [DOI] 10.3389/fimmu.2021.796094 PMC 바로가기 [Article Type] Immunology
Allergic patients during the COVID‐19 pandemic—Clinical practical considerations: An European Academy of Allergy and Clinical Immunology surveyOriginal Article Published on 2022-01-172022-10-31 Journal: Clinical and Translational Allergy [Category] COVID-19, [키워드] Academy affected allergen immunotherapy allergic allergic rhinitis allergies allergy anaphylaxis Asthma biologics Care changed clinical consequence Corticosteroid COVID‐19 COVID‐19 diagnostic European evaluate food allergies food allergy hcp Health Health care system ICS Immunotherapy indicated inhaled corticosteroid initiated International intervals intranasal management Modification modify MOST oral pandemic Patient professional recommendations reduction remote reported Result significantly survey Telemedicine therapeutic approaches Treatment was increased [DOI] 10.1002/clt2.12097 PMC 바로가기 [Article Type] Original Article
PRCTC: a machine learning model for prediction of response to corticosteroid therapy in COVID-19 patientsResearch Paper Published on 2022-01-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval applied AUC C reactive protein China Clinical data clinical decision Cohort collected Corticosteroid corticosteroid therapy COVID-19 COVID-19 patient COVID-19 patients dataset decision effective evaluated external validation feature FIVE Gradient hospital Hospitalization Logistic regression lymphocyte lymphocyte percent machine learning management medication network Neural outcome oxygen supply patients predict Predictive receiving Selection Shrinkage Support the patient treatments for COVID-19 tree validation cohort [DOI] 10.18632/aging.203819 PMC 바로가기 [Article Type] Research Paper
Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)—study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trialARDS 및 COVID-19 환자에서 덱사메타손의 효과(REMED 시험) - 전향적, 다기관, 공개 라벨, 병렬 그룹, 무작위 대조 시험을 위한 연구 프로토콜Update Published on 2022-01-152022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 Administered Adult patients adverse event adverse events age ARDS ARMS Barthel Index Charlson Comorbidity Index clinical Comorbidity conducted consequence Corticosteroid Corticosteroids COVID-19 COVID-19 pneumonia CRP level CRP levels Czech Republic deleterious effect Dexamethasone dexamethasone 6 mg different dose dose doses of corticosteroids Effect Efficacy and safety enrolled EudraCT Factor followed by ICUs Independence Inflammatory intensive care unit intensive care units intravenously life marker mechanical ventilation moderate to severe Mortality once daily Open-label outcome oxygen Oxygen therapy parallel-group participant patients with ARDS patients with COVID-19 patients with moderate per day Pneumonia Prevent primary endpoint protocol Quality of life randomisation randomised randomised controlled trial randomization Randomized controlled trial SARS-CoV-2 virus scale secondary endpoint Secondary endpoints severe ARDS Stratification therapeutic potential Treatment Trial Trial registration university hospital ventilator-free day Ventilator-free days WHO [DOI] 10.1186/s13063-021-05963-6 PMC 바로가기 [Article Type] Update