Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG고역가 항중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 스파이크 단백질 IgG를 포함하는 회복기 혈장으로 조기에 수혈된 환자Article Published on 2021-01-012022-09-12 Journal: The American journal of pathology [Category] SARS, 진단, [키워드] aggregate Analysis Anti-RBD IgG Anti-spike authorization Cohort Containing convalescent plasma coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 patient Cutoff decrease Decreased drug early treatment Emergency enzyme-linked immunosorbent facilitated Follow-up food highest Hospitalization hospitalized COVID-19 patients hospitalized patients IgG interim analysis median Mortality Ortho Vitros Prospective Protein RBD RBD IgG Receptor binding domain reduce reported respiratory SARS-CoV-2 significantly spike therapy transfused [DOI] 10.1016/j.ajpath.2020.10.008 PMC 바로가기 [Article Type] Article
Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection비고전적 CD14dimCD16+ 단핵구의 수와 표현형은 관상동맥 질환 및 중증 SARS-CoV-2 감염 환자에서 불리한 임상 결과의 예측인자입니다Article Published on 2021-01-012022-08-31 Journal: Cardiovascular Research [Category] 바이오마커, 진단, [키워드] acute SARS-CoV-2 infection adhesion Admission assessment Blood blood sampling CAD CD14 CD80 classical monocytes clinical assessment Clinical outcome Cohort Complication consecutive patient Coronary artery Coronary artery disease CX3CR1 Decreased decreased expression defined echocardiography Electrocardiography Endpoint Follow-up healthy control healthy controls help HLA-DR identify immune response Immuno-response index Infection infections Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves life-threatening log-rank Lung injury marker mechanical ventilation median Migration monocyte Monocytes non-classical monocyte Non-classical monocytes number Occurrence participant Patient Peripheral blood phenotype Phenotypes predictor prognostic progressive respiratory failure prospectively studied reached respiratory Respiratory failure risk risk assessments SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients severe SARS-CoV-2 significantly more stratified subsequent T-cell activation the median [DOI] 10.1093/cvr/cvaa328 PMC 바로가기 [Article Type] Article
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients염증 마커 miR-146a의 감소된 혈청 수준은 COVID-19 환자에서 토실리주맙에 대한 임상적 무반응과 관련이 있습니다Clinical Trial Published on 2021-01-012022-09-11 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] accounted adverse outcome affected age anti-IL-6 receptor biologic Biomarker Clinical course clinical response clinical trial COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity current death Decreased develop Digital disease droplet enrolled examined Health Healthcare systems healthy control inflammaging interleukin-6 interstitial pneumonia intravenous intravenous infusion lowest marker microRNA MicroRNAs miR-126 miR-146 miR-146a-5p miR-21 molecular non-responders Patient PCR quantified regulate respond responders RT-PCR Serum level serum levels serum sample serum samples subjects syndrome TCZ Tocilizumab Treatment [DOI] 10.1016/j.mad.2020.111413 PMC 바로가기 [Article Type] Clinical Trial
Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech RepublicCommunication Published on 2020-12-162022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory viral infection affected age all age group Case-fatality rate CFR COVID-19 COVID-19 pandemic COVID-19 patients Czech Republic Decreased demonstrated effective elderly Epidemic home inosine pranobex Ireland Natural killer cells Nursing nursing homes Odds ratio PCR Rate reduced SARS-CoV-2 significant difference significantly statistically significant tested the SARS-CoV-2 virus Treatment Trial viral respiratory infections [DOI] 10.3390/pathogens9121055 PMC 바로가기 [Article Type] Communication
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19혈청 스핑고신-1-인산 수치 감소: COVID-19의 임상 중증도에 대한 새로운 예측인자Article Published on 2020-12-092022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] Admission albumin Anemia apoM Biomarker Biomarkers & Diagnostic Imaging Blood C‐reactive protein circulating Clinical severity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CRP D‐dimer decrease Decreased erythrocytes evaluate ferritin fibrinogen healthy subject intensive care intensive care unit Lactate lactate dehydrogenase LDH lymphocytopenia Microbiology, Virology & Host Pathogen Interaction neutrophil normal range outcome Patient patient treatment plasma prognostic biomarker reduction Restoring serum Serum level severity significant increase significantly sphingosine‐1‐phosphate therapeutic target [DOI] 10.15252/emmm.202013424 PMC 바로가기 [Article Type] Article
Time dynamics of COVID-19Article Published on 2020-12-032022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] Case fatality rate country covariate COVID-19 COVID-19 case cumulative Data analysis death Decreased determine doubling Effect Epidemiology facilitate functional information initial positive Regression model Scientific data Statistics time trajectory [DOI] 10.1038/s41598-020-77709-4 PMC 바로가기 [Article Type] Article
COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a +COVID-19 유발 ARDS는 CD11a +를 발현하는 활성화된 기억/이펙터 T 세포의 빈도 감소와 관련이 있습니다Article Published on 2020-12-022022-09-12 Journal: Molecular therapy : the journal of the American So [Category] MERS, SARS, 진단, [키워드] accompanied activated acute respiratory distress analyzed Antiviral ARDS ARDS patient CD4 CD8 Characteristics circulating circulation COVID-19 COVID-19 patients COVID-19-associated ARDS Decreased demonstrated expressing flow cytometry Frequency functional generate identify immune cells immune signature Immunity intensive care marker Migration outcome Patient patients Peripheral blood phenotypic Predictive Preventing Prognostic marker progression Quantitative S-protein-reactive T cells SARS-CoV-2 significantly higher survival syndrome T cell T cell subset tissue two groups [DOI] 10.1016/j.ymthe.2020.10.001 PMC 바로가기 [Article Type] Article
Clinical comorbidities, characteristics, and outcomes of mechanically ventilated patients in the State of Michigan with SARS-CoV-2 pneumoniaObservational Study Published on 2020-12-012022-10-04 Journal: Journal of clinical anesthesia [Category] 임상, [키워드] administration age Characteristics clinical Comorbidities coronavirus CRRT Decreased enrolled greater hypertension Increased increased mortality mechanical ventilation mechanically ventilated patient Mortality outcome Patient patients treated renal replacement therapy risk SARS-CoV-2 SARS-CoV-2 pneumonia state steroid Urine Vitamin C [DOI] 10.1016/j.jclinane.2020.110005 PMC 바로가기 [Article Type] Observational Study
Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study보체 C3 수치 감소는 COVID-19 환자의 나쁜 예후와 관련이 있습니다: 후향적 코호트 연구Observational Study Published on 2020-12-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 진단, [키워드] Admission analyzed breath Chest complement Complement C3 Complement pathway coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Decreased died discharged effective enrolled Factors greater hospital humoral Humoral immune Humoral immunity IgA IgE IgG IgM immune Immunoglobulin In-hospital death incidence Inflammatory indicators inhibition leukocyte Lymphocyte subsets management multivariable logistic regression Multivariable regression non-survivor Older age Patient performed poor prognosis retrospective cohort study risk factor Risk factors significantly survival survival group Survivors therapeutic transferred [DOI] 10.1016/j.intimp.2020.107070 PMC 바로가기 [Article Type] Observational Study
The effects of allium sativum on immunity within the scope of COVID-19 infection코로나19 감염 범위 내에서 부추속이 면역력에 미치는 영향Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 치료기술, [키워드] abnormality activated active against Acute respiratory infection adipose Adipose tissue Allium allium sativum antiinflammatory antimicrobial antiviral efficiency appear Appetite Asymptomatic disease boost characteristic Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokines decrease Decreased demonstrated dry cough dysfunction Dyspnea Effect expression fatigue Features functional functional food Garlic Gustatory helper helper T cells immune system immune system cell immune system cells Immune system dysfunction Immunity immunological immunomodulatory infected with SARS-CoV-2 Infection Leptin loss of appetite macrophages manifestation Manifestations Monocytes monocytes/macrophage monocytes/macrophages myalgia natural Natural killer cells olfactory parameters patients with COVID-19 prevalent preventive measure proinflammatory Proinflammatory cytokine proinflammatory cytokines Protein protein kinase protozoan parasites receptor regulatory T cells repress SARS-CoV-2 virus secretion severity suggested suppressed Symptom Symptoms T cells T lymphocytes tissue virus [DOI] 10.1016/j.mehy.2020.109934 PMC 바로가기 [Article Type] Article