Deleterious – Page 12 – Communicable Diseases Research

Angiotensin-(1-7)—A Potential Remedy for AKI: Insights Derived from the COVID-19 Pandemic

Review

Published on 2021-03-132022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial

COVID-19(FLARE) 외래 환자의 조기 항바이러스 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-03-082022-09-01
Journal: Trials [Category] SARS, 임상, 진단, 치료기술, 치료제,

[키워드] 24 hours 48 hour 48 hours absence admitted to ICU aetiology age ALT Analysis Anosmia anticipated antiviral therapy Antiviral treatment antivirals Appendix Arm arrhythmia AST Asthma Asymptomatic Autoimmune blinded to treatment Blinding blood sample BMI Breastfeeding childbearing potential Cholangitis chronic chronic hepatitis Chronic kidney disease chronic liver disease chronic respiratory disease cirrhosis clinical condition collected combination therapy Comorbidity concealed Concomitant concomitant medications conducted COPD coryza cough COVID-19 COVID-19 disease COVID-19 vaccine criteria current Date Day decrease defined Deleterious detectable diabetes died disease dissemination dose double-blind Duration early treatment effective EGFR element enrolled enrolment Ethnicity examined exclusion criteria factorial design Favipiravir female female participant Fever followed by Free Gender headache heart disease Hepatitis hepatotoxicity HIV infection hospital hospitalisation hypersensitivity hypertension in viral include inclusion criteria ingredient investigator investigators Ischaemic heart disease Kidney disease liver Liver disease London Lopinavir Lopinavir/ritonavir malaise male participant male participants measure medication Mutation myalgia Myocardial infarction no symptom non-hospitalised not limited number obesity objective observational studies observational study oral outcome Outpatient outpatients participant Participants partner percentage pharmacokinetic phase IIa Placebo placebo-controlled placebo-controlled trial positive presence or absence Primary outcome Proportion of participant Protease inhibitor protocol randomised randomised controlled trial Rate Registered Registration respiratory Respiratory disease risk Ritonavir Safety Saliva saliva samples Sample size SARS-CoV-2 secondary Secondary outcomes Shortness of breath smoker smoking smoking status Stage status steatohepatitis Stool Study protocol supplementary material Symptom symptom onset symptomatic tested therapy Toxicity Treatment treatment allocation Trial trial medication Trial registration undetectable United Kingdom upper respiratory tract vaccine trial valvular valvular heart disease Viral Viral load website with COVID-19
[DOI] 10.1186/s13063-021-05139-2 PMC 바로가기 [Article Type] Letter

Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level

Article

Published on 2021-03-052022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] acute respiratory syndrome amino acid substitution Analyzer B.1.1.7 B.1.1.7 lineage Bayesian Bayesian analysis Clustering collected concern coronavirus country COVID-19 COVID-19 case D614G Deleterious Effect Epidemiology Evolution Genetic genetic variability highest increase in Infection introduced investigated Jordan Level likelihood Lineage lineages manifested middle-income country molecular Mutation Non-synonymous mutation Phylogenetic Phylogenetic analysis proportion PROVEAN resulting SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 sequence spike gene spike glycoprotein Spread Substitution synonymous UK variant variant variant of concern
[DOI] 10.3390/pathogens10030302 PMC 바로가기 [Article Type] Article

Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID‐19 disease

Original Article

Published on 2021-03-042022-10-29
Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS,

[키워드] ACE ACE2 ADAM17 Ang II angiotensin converting enzyme 2 binding domain BNP cell membranes clinical setting compensated component contribute Control controls correlation COVID‐19 Deleterious disease disease severity distribution downregulated ENhance enzyme expression furin group heart heart failure hearts immunoreactivity increased expression isoform kidney lung male mechanism mRNA level oedema overexpressed Patient plasma Potential proportion pulmonary pulmonary dysfunction RAAS receptor remained renal renal system renal tissue SARS‐CoV‐2 SARS‑CoV2 severity sodium staining surgical susceptibility the disease tissue tissue remodelling TMPRSS2 urinary sodium was increased while
[DOI] 10.1111/jcmm.16310 PMC 바로가기 [Article Type] Original Article

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

남성에서 생명을 위협하는 COVID-19 질병과 Toll 유사 수용체 7 변이의 연관성: 중첩 사례 대조 연구의 결과

Short Report

Published on 2021-03-022022-09-10
Journal: eLife [Category] SARS, 변종, 유전자 메커니즘,

[키워드] affected Analysis applied Asymptomatic case-control study clinical Cohort conditioned contributing to Control COVID-19 Deleterious demonstrated disease disease susceptibility disorder Donor expression profile extreme functional gene funding GEN-COVID Gene Expression Human iceberg IFN impairment initiative investigated Italian LASSO Logistic Regression Analysis life-threatening COVID-19 disease loss-of-function male male participant male participants participant Participants Patient patients phenotype rare variant Rare variants reduction in Regression regression analysis responses SARS-CoV-2 selected Severe case severe COVID-19 subset susceptibility TLR7 toll-like receptor 7 Trial type I variant X-linked
[DOI] 10.7554/eLife.67569 PMC 바로가기 [Article Type] Short Report

Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

Observational Study

Published on 2021-02-172022-10-04
Journal: Diabetologia [Category] MERS, SARS, 임상,

[키워드] 95% CI Abstract Admission Admission plasma glucose age Anticoagulant Aspartate aminotransferase C-reactive protein clinician Complication complications coronavirus COVID-19 death Deleterious diabetes Diabetic died discharge discharged Dyspnoea Factor Factors Follow-up French HbA_1c help history Home discharge hospital Hospital admission hospital discharge Hospital stay hospitalised insulin mechanical ventilation median Median BMI men Mortality multicentre Multivariable models outcome pandemic participant Participants Patient patients with diabete peer-reviewed Prognostic factor reduced Result SARS-CoV-2 screened supplementary material symptom duration therapy Treatment white cell
[DOI] 10.1007/s00125-020-05351-w PMC 바로가기 [Article Type] Observational Study

Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19

경증 또는 중증 COVID-19를 가진 여성의 태반 내피에서 혈전 및 미세혈관 손상에 대한 분자적 통찰력

Article

Published on 2021-02-102022-09-11
Journal: Cells [Category] MERS, 바이오마커, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus binding cadherin cells chorionic chorionic villus claudin claudin-5 clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decidua decrease Deleterious disease severity endothelial Endothelium expression healthy controls histological analysis immunofluorescence increases in insight Mild Mild disease Placenta placental Placentas pregnant women receptor ACE2 respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 the disease thrombosis variety Vascular VE-cadherin vessels villus von Willebrand factor with COVID-19 with mild disease women
[DOI] 10.3390/cells10020364 PMC 바로가기 [Article Type] Article

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

렌티바이러스 벡터를 사용한 비강내 백신은 전임상 동물 모델에서 SARS-CoV-2로부터 보호합니다

Article

Published on 2021-02-102022-09-12
Journal: Cell Host & Microbe [Category] MERS, SARS, 진단,

[키워드] Ad5 adenoviral vector animal model approach beta-coronavirus boost boost-target coronavirus disease COVID-19 decrease Deleterious develop Effect Efficacy Evidence expression glycoprotein golden hamsters hamsters immune response immunization Immunoglobulin immunoglobulin A in vivo in vivo Ad5 transduction inhibit Injury intranasal intranasal vaccination lentiviral lentiviral vectors local inflammation log lung Lung inflammation lung viral load mice mucosal mucosal immunity Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody platform Prophylactic PROTECT receptor hACE2 reduce respiratory tract respiratory tract cell respiratory tracts respiratory tracts. SARS-CoV-2 SARS-CoV-2 replication serum systemic the SARS-CoV-2 the Spike vaccination Vaccine vaccine candidate
[DOI] 10.1016/j.chom.2020.12.010 PMC 바로가기 [Article Type] Article

Measuring the impact of delayed access to elective cholecystectomy through patient’s cost-utility: an observational cohort study

Observational Study

Published on 2021-02-082022-10-05
Journal: International journal for quality in health care : [Category] 임상,

Substance use, mental health and weight‐related behaviours during the COVID ‐19 pandemic in people with obesity

Original Research Article

Published on 2021-02-042022-10-31
Journal: Clinical obesity [Category] COVID-19, MERS, SARS,

[키워드] 95% CI adjusted age alcohol Anxiety asleep BMI COVID COVID‐19 COVID‐19 Deleterious drugs Ethnicity female General population Health healthy Infection lifted lockdown mental health obesity pandemic Patient patients with obesity positive primary outcome measure question Ratio reported reported symptoms Result retrospective SARS‐CoV‐2 shown substance Substance use tested
[DOI] 10.1111/cob.12440 PMC 바로가기 [Article Type] Original Research Article