Predicting Mutational Effects on Receptor Binding of the Spike Protein of SARS-CoV-2 VariantsSARS-CoV-2 변이체의 스파이크 단백질 수용체 결합에 대한 돌연변이 효과 예측Article Published on 2021-10-272022-09-11 Journal: Journal of the American Chemical Society [Category] SARS, 변종, 유전자 메커니즘, [키워드] Amino acid amino acids antibody antibody m396 approach binding binding affinity calculate caused change correlated Delta delta variant Delta variants domain Effect Effectiveness experiments faster free energy functional higher infectivity in silico investigated m396 mechanism mutant mutants mutate Mutation mutations offer Other pandemic predict predicted problem provided receptor reduction SARS-CoV-2 South Africa speed Spike protein Surveillance the binding affinity the Spike variant variants virus was done was used were assessed [DOI] 10.1021/jacs.1c07965 PMC 바로가기 [Article Type] Article
Genomic reconstruction of the SARS-CoV-2 epidemic in England영국 SARS-CoV-2 전염병의 게놈 재구성Article Published on 2021-10-142022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant Analysis B.1.617.2 coronavirus COVID-19 declined Delta Delta variants E484K mutation eliminated England English Epidemic epidemiological Epidemiology Evolution Evolutionary genetics exceeded followed by genomic Genomics Intervention introduced jump leads Lineage Local lockdown National peaked proportions respiratory reveal SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus suppressed Surveillance sustained the SARS-CoV-2 the SARS-CoV-2 virus Transmissibility unlikely variant variants viral infection virus [DOI] 10.1038/s41586-021-04069-y PMC 바로가기 [Article Type] Article
Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 AffinitySARS-CoV-2의 알파, 카파 및 델타 변이체의 더 높은 투과율과 스파이크 단백질 및 hACE2 친화도의 구조적 안정성 증가 사이의 가능한 연결Article Published on 2021-08-242022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] (Alpha) acute respiratory syndrome coronavirus affinity Alpha Alpha variant B.1.1.7 B.1.617.1 B.1.617.2 binding affinity binding energy caused Complexes coronavirus coronavirus 2 COVID-19 Delta Delta variants E484Q false negativity global pandemic globe hACE2 hydrogen Immune escape increase in Increased Infection Interaction interactions L452R Lineage molecular molecular dynamic simulations molecular mechanism mutant mutants Mutation mutation rate N501Y N501Y mutation Neutralizing antibodies neutralizing antibody outbreak PCR tests performed Perspective provide rationale Receptor binding Receptor binding domain Reinfection respiratory RT-PCR tests SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase spike Spike protein spike variants stability T478K T478K and L452R mutation the spike protein transmissivity variants virus wild-type SARS-CoV-2 wildtype [DOI] 10.3390/ijms22179131 PMC 바로가기 [Article Type] Article
Predicted dominance of variant Delta of SARS-CoV-2 before Tokyo Olympic Games, Japan, July 20212021년 7월 일본 도쿄 올림픽 전에 SARS-CoV-2 변종 Delta의 우세 예측Rapid Communication Published on 2021-07-082022-09-10 Journal: Eurosurveillance [Category] SARS, 변종, 치료기술, [키워드] Alpha assumed circulating Delta delta variant Delta variants distributions expected Frequency instantaneous Japan RRI relative instantaneous reproduction numbers Reproduction number SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants strain Tokyo Tokyo Olympic Games variant [DOI] 10.2807/1560-7917.ES.2021.26.27.2100570 PMC 바로가기 [Article Type] Rapid Communication