downregulated
[용어속성] Action
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients
Research
Published on
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, SARS,
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, SARS,
[키워드] ACE2
ACE2 receptor
Analysis
binding
cancer patient
Cancer patients
cells
conducted
COVID19
database
dataset
downregulated
elevated
expression
frailty
help
HNSCC
host cell
HPV
independent
inherent
lung cancer
lung tissue
men
Methylation
microRNA
microRNAs TP53
mutated
MYC
observation
Patient
positive
promoter
protease
Protein
reduced
Result
S priming
SARS-CoV-2
SARS-COV-2 infection
significantly
statistically significant
subsequent
the Spike
tissue
tissues
TMPRSS2
TMPRSS2 expression
TMPRSS2 protease
TP53
tumors
variable
women
[DOI] 10.1186/s13046-020-01708-6 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s13046-020-01708-6 PMC 바로가기 [Article Type] Research
Differential microRNA expression in the peripheral blood from human patients with COVID‐19
Research Article
[키워드] acute respiratory syndrome
Bioinformatics analysis
biological processes
blood cell
category
caused
cellular components
cluster analysis
controls
coronavirus
coronavirus disease
Correlation analysis
COVID‐19
COVID‐19 patient
COVID‐19 patients
COVID‐19
differential expression
differentially expressed
donors
downregulated
enrichment analysis
expression
expression level
Extract
Gene Expression
healthy donors
high‐throughput sequencing
highest
immune response
microRNA
miRNA
miRNA expression
miRNAs
molecular functions
Patient
peptidases
Peripheral blood
protein kinases
purified
reduction
regulate
Regulation
SARS‐CoV‐2
Sequencing
shown
target gene
the healthy
total RNA
upregulated
viral infection
viral replication
was performed
was reduced
[DOI] 10.1002/jcla.23590 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1002/jcla.23590 PMC 바로가기 [Article Type] Research Article
Presence of Genetic Variants Among Young Men With Severe COVID-19
Case Reports
[키워드] acute respiratory syndrome
affected
age
Analysis
Blood
carried
case sery
caused
Cell
chronic disease
Control
controls
coronavirus
coronavirus disease
COVID-19
criteria
died
downregulated
downstream
experiments
exposure
Final
finding
Follow-up
functional
Genetic
Genetic variant
hospital
ICU
identify
IFN
IFN-γ
IFNB1
immune defects
immunodeficiency
immunological
Immunological test
Importance
individual
intensive care
interferon
interferon signaling
IRF7
ISG15
loss-of-function
male
measure
mechanical ventilation
Medical conditions
men
missense variant
mononuclear cell
mRNA expression
Netherland
Netherlands
objective
occur
one patient
participant
pathogenesis of COVID-19
Patient
patients
patients hospitalized
patients with COVID-19
performed
Peripheral blood
Point
preliminary finding
Presence
primary immune cell
Rapid
Relevance
responses
Result
SARS-CoV-2
setting
severe coronavirus disease
severe COVID-19
Severe infection
Signaling
significantly
the mean
the patient
TLR7
transcriptionally
type I
type I interferon
type II IFN
variant
ventilatory support
whole-exome sequencing
[DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports
[DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports
Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past
Immunology
[키워드] acute phase
against SARS-CoV
antibody production
association
attack
B cell
caused
classical
clinical trial
combating
complexes
component
contagious
convalescent plasma
coronavirus
Coronaviruses
correlated
COVID-19
COVID-19 patients
cross-reactivity
cytokine
cytokine secretion
cytolytic
develop
disease
disease severity
downregulated
drug
expression
flu
Genome sequencing
group
help
highlight
HIV
HLA
Host
identify
IFNs
IL-6
immune response
Immunotherapy
induce
infected individual
infected individuals
Infection
Influenza
initiated
interferon
lesson
limitation
Local
lymphopenia
malaria
memory
memory T cell
MERS
MERS-CoV
MHC
MHC allele
MHC alleles
MHC presentation
molecular
neutralization
neutralizing antibody
Novel coronavirus
nucleocapsid protein
pandemic
pathogenicity
Plasma transfusion
Pneumonia
polymorphism
populations
preventive measures
protective response
Rapid
recovered patient
reported
researcher
Respiratory system
response
resulting
SARS-CoV-2
similarity
specific treatment
Stage
Symptom
T cell epitope
T cells
T-cell
TNF-α
Treatment
treatment strategy
Tuberculosis
Type
Viral antigen
viral infection
Viremia
virus
virus particle
[DOI] 10.3389/fimmu.2020.01949 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.01949 PMC 바로가기 [Article Type] Immunology
Expansion of Single Cell Transcriptomics Data of SARS-CoV Infection in Human Bronchial Epithelial Cells to COVID-19
Research
[키워드] Activation
acute respiratory syndrome
addition
Analysis
applied
association
Atla
B- and T-cells
bronchial
bronchial epithelial cell
bronchial epithelial cells
cell line
coronavirus
coronavirus disease
COVID-19
COVID-19 patients
Critical
Cytokine storm
database
dendritic cells
downregulated
downregulated gene
expand
expansion
expected
functional gene
Gene ontology
Golgi
highest
homolog
Human
Hyperactivation
immune system
immunological
Immunological regulations
infected cell
Ontology
overlap
pathway
phosphatase
platform
Proinflammatory cytokine
proinflammatory cytokines
Protein
PTEN
Reactome pathways
Regulation
Result
SARS-CoV
SARS-CoV infection
SARS-CoV-2
secretion
Severe acute respiratory syndrome
shown
signaling pathways
similarity
Single Cell
Spread
System biology
to define
Transcriptome
transcriptomics
Transport
Vaccine
Wuhan, China
[DOI] 10.1186/s12575-020-00127-3 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12575-020-00127-3 PMC 바로가기 [Article Type] Research
Putative Roles for Peptidylarginine Deiminases in COVID-19
Article
[키워드] A549 cell lines
A549 cells
addition
alveolar
alveolar cell
Analysis
Anti-viral
autoimmune conditions
BioProject
biopsy
bowel
cells
changes
Comorbidities
conserved
contributing to
COVID-19
COVID-19 symptoms
disease
downregulated
elevated
enzyme
epithelial
expression
Extracellular
extracellular vesicles (EVs)
fat
Health
healthy volunteer
highlight
Immunity
implicated
in silico analysis
in viral
in-host
infected cells
Infection
infections
Inflammatory
inflammatory pathways
isozyme
KEGG
kidney
Kidney injury
lung
lung epithelial
lung tissue
mock cells
modulation
mRNA
mRNA level
NETosis
NHBE
organ
other tissue
PADI1
PADI2
PADI3
PADI4
PADI6
Pathway analysis
Patient
peptidylarginine deiminases (PADs)
phylogenetically
Protein
protein deimination
reduced
Regulation
response
responses
reveal
role
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2-infected patients
stroke
therapeutic target
tissue
tissue biopsies
Transcriptome
utilised
Variability
Variation
Vascular
Vesicle
viral infections
[DOI] 10.3390/ijms21134662 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms21134662 PMC 바로가기 [Article Type] Article
Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial Cells
Article
[키워드] ACE2
ACE2 blocker
ACE2 expression
Acetate
acute respiratory syndrome
addition
Analysis
angiotensin-converting enzyme 2
Anti-viral
anti-viral agent
Cell
citronellol
Compound
contribute
coronavirus
COVID-19
downregulated
epithelial cells
Essential
evaluated
Gas Chromatography-Mass Spectrometry
Geranium
geranium essential oil
health emergency
host cell receptor
inhibitory effect
Inhibitory effects
Intervention
Invasion
lemon
lemon essential oil
lemon oil
limonene
Oil
pandemic disease
qPCR analysis
receptor
SARS-CoV-2
significantly
spike
TMPRSS2
Treatment
virus
[DOI] 10.3390/plants9060770 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/plants9060770 PMC 바로가기 [Article Type] Article
Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3
Article
[키워드] acute respiratory syndrome
Amino acid
Analysis
antagonistic
antiviral response
cause
Cell
component
coronavirus
correlated
Critical
degrade
dependent on
disease
downregulated
endoribonuclease
epidemic diarrhea
facilitate
Host
IFN
IFN response
IFN signaling pathway
IFN-I
Infection
inhibit
innate immune
innate response
interferon regulatory factor
interferon signaling
involved
IRF3
ISGs
Nsp15
other coronaviruses
pathogenic mechanism
pathway
PEDV
Protein
reduction
Replication
residue
RNA
RNA degradation
SARS-CoV
screened
stimulated
suppress
TBK1
type I interferon
virus
virus infection
[DOI] 10.3390/v12060599 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v12060599 PMC 바로가기 [Article Type] Article
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells
Article
[키워드] ACE2
acute respiratory syndrome
angiotensin-converting enzyme 2
category
cell entry receptor
China
coronavirus
COVID-19 patient
digestive
downregulated
enrichment
Evidence
expression pattern
Gene ontology
GO term
GSEA
Human
indicate
Infection
male
Novel coronavirus
pathophysiology
Presence
Profiling
provided
rapidly spreading disease
reproductive
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
scRNA-seq
sequence similarity
Sertoli
Sertoli cells
single-cell transcriptomes
spermatogonia
target
Teste
Transmission
Wuhan
[DOI] 10.3390/cells9040920 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/cells9040920 PMC 바로가기 [Article Type] Article