Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?COVID-19 관리를 위한 Artemisia 추출물 및 Artemisinin 기반 항말라리아제: 이것이 COVID-19 치료에 효과적인 항바이러스제일 수 있습니까?Review Published on 2022-06-142022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 말라리아, 신약개발, 치료제, [키워드] active against acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Anti-inflammatory effects Antiviral Artemisia Artemisinin artemisinins combination therapies coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated derivative derivatives Drug repurposing Effect Effectiveness Evidence exhibit Extract IL-6 Infection Inflammation inhibiting interleukin-6 Invasion lung damage malaria other diseases oxidative stress pandemic positive reducing Replication SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Symptoms the SARS-CoV-2 treat Treatment [DOI] 10.3390/molecules27123828 PMC 바로가기 [Article Type] Review
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article
Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19COVID-19의 잠재적 치료제로서 약물 용도 변경 후보를 스크리닝하기 위한 TMPRSS2 분석 제품군Article Published on 2022-06-102022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료제, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells Antiviral antiviral therapeutics antiviral therapy approved drug approved drugs bind biochemical biochemical assay camostat candidate cleavage clinical trial clinical trials Compound COVID-19 COVID-19 pandemic driving drug Drug repurposing effective antiviral treatment fluorescent followed by high-throughput screening. human clinical trial human clinical trials inhibiting inhibitors of TMPRSS2 Initially Japan mass spectrometry molecule nafamostat otamixaban PCI-27483 Potential Prevent protease Protease activity pseudotyped Receptor-binding domain repurposing SARS-CoV-2 Screening Spike protein symptom onset tested the receptor-binding domain the spike protein Therapies therapy TMPRSS2 Vaccine viral entry viral pathogen [DOI] 10.1021/acsinfecdis.2c00172 PMC 바로가기 [Article Type] Article
A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) InhibitorsSARS-CoV-2 주요 프로테아제(3CLpro) 억제제 식별을 위한 약물 용도 변경 연구Article Published on 2022-06-092022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Antiviral antiviral activity artificial artificial intelligence caused Cell Combination Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cynarine cytotoxicity docking drug Drug repurposing eravacycline FRET in silico in vitro infected with SARS-CoV-2 inhibitory activity inhibitory compounds intelligence MPro outbreak phase prexasertib protease repurposing safety profile SARS-CoV-2 SARS-CoV-2 3CL protease SARS-CoV-2 main protease selected severe acute respiratory syndrome Coronavirus tested the disease Treatment trials Vaccine VeroE6 cell VeroE6 cells were used [DOI] 10.3390/ijms23126468 PMC 바로가기 [Article Type] Article
Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysisResearch article Published on 2022-06-022022-10-05 Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발, [키워드] affected Analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 Therapeutic approach Transcriptome viral replication viral strain virus [DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article
Organ-specific or personalized treatment for COVID-19: rationale, evidence, and potential candidatesArticle Published on 2022-06-012022-10-04 Journal: Functional & integrative genomics [Category] COVID19(2023년), SARS, 신약개발, [키워드] A549 acute respiratory syndrome analyzed biological pathway candidate Cell Complication coronavirus coronavirus disease COVID-19 DEGs differentially expressed gene Drug repurposing effective Evidence experiment extrapulmonary organ FDA-approved drug Genes increasingly infected cell involved liver lung alveolar manifestation Multiorgan multisystemic network analysis organ organ-specific Organ-specific treatment Organoid organs Pathogenesis pathophysiology Pathway enrichment analysis Personalized medicine pluripotent stem cell PPI protein-protein interaction reported responsible SARS-CoV-2 SARS-COV-2 infection therapeutic therapeutic strategy therapy Treatment was done were used [DOI] 10.1007/s10142-022-00841-z PMC 바로가기 [Article Type] Article
Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro다양한 용도 변경 약물과 결합된 몰누피라비르는 시험관 내 인간 비강 상피에서 SARS-CoV-2 감염을 추가로 억제합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Air-liquid interface antiviral activity Antiviral treatment antiviral treatments antivirals caused cellular Clinical efficacy clinical testing clinically Combination combinations complex Compound Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug drug combination drug combinations Drug repurposing effective effective antiviral treatment effort Emergency use evaluated highlighting identify Immunity in vitro in vitro model inhibit inhibiting molnupiravir nasal epithelium Potential treatment Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected severe acute respiratory syndrome Coronavirus short duration tested the vaccine These data Treatment Vaccine variant worldwide pandemic [DOI] 10.1016/j.biopha.2022.113058 PMC 바로가기 [Article Type] Article
Challenges of rapamycin repurposing as a potential therapeutic candidate for COVID-19: implications for skeletal muscle metabolic health in older personsCOVID-19의 잠재적인 치료 후보로 라파마이신 용도 변경의 도전: 노인의 골격근 대사 건강에 대한 영향Editorial Published on 2022-06-012022-09-11 Journal: American journal of physiology. Endocrinology and [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration affected aging anabolic anabolic resistance antiviral medication attenuate bed rest block blunting causative agent Cell cell growth challenge clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization death Decline demonstrated downstream drug Drug repurposing Effect effective effective vaccine Effective vaccines effectors greater growth Health healthy Hospitalization Human implication lack master regulator Mortality MPS mTOR muscle loss muscle mass muscle protein muscle protein synthesis muscle protein synthesis. Older pandemic Pandemics Rapamycin reduced resulting risk SARS-CoV-2 sedentariness Severe infection Skeletal muscle Spread susceptible the disease therapeutic with COVID-19 younger patients [DOI] 10.1152/ajpendo.00064.2022 PMC 바로가기 [Article Type] Editorial
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo대규모 in vitro 스크리닝 및 in vivo 효과 평가를 통한 잠재적 anti-SARS-CoV-2 약물 발굴Article Published on 2022-06-012022-09-11 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug approved drug candidate caused Cell culture cisatracurium clinical clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment cytotoxicity D614G D614G variant develop drug Drug repurposing drug resistance Drug screening drugs effective Efficacy Gilteritinib hamster hamster model. hamsters HeLa cell HeLa cells human ACE2 IL-6 in vitro in vivo induce life cycle mRNA pandemic passage Postinfection promoted Prophylactic protective effect provided pulmonary viral reduced Remdesivir Salinomycin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle selected sertraline severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown suppressed the SARS-CoV-2 TNF-α transduced Treatment variety Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1007/s11427-021-2031-7 PMC 바로가기 [Article Type] Article