Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study영국 런던의 신종 SARS-CoV-2 B.1.1.7 계통의 게놈 특성 및 임상 효과: 전체 게놈 시퀀싱 및 병원 기반 코호트 연구Article Published on 2021-09-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] adjusted age analysed Analysis association B.1.1.7 B.1.1.7 variant Characteristics Clinical effect Clinical severity Cohort cohort study collected college Comorbidities Council Cycle threshold value death defined emergence Engineering epitope Epitopes Ethnicity Evidence evidence of genomic genomic read hospital hospitalised identify Immunocompromised patient Immunocompromised patients inclusion criteria Infection Lineage London mass vaccination monoclonal antibodies Mutation mutations NHS NIHR no evidence of Ordinal Scale Patient patients PCR PCR cycle Poisson regression model Poisson regression models positive Positive test Prevalence raise Remdesivir SARS-CoV-2 SARS-CoV-2 B.1.1.7 Science sequenced Sequencing severe disease Sex specific mutation specific mutations Spike protein Symptom the spike protein the WHO threshold value Transmissibility Trust university vaccination variant variants Viral load Virological virus load VoC WHO ordinal scale whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00170-5 PMC 바로가기 [Article Type] Article
Emergence of highly infectious SARS-CoV-2 variants in Bangladesh: the need for systematic genetic surveillance as a public health strategyLetter to the Editor Published on 2021-09-012022-10-28 Journal: Tropical Medicine and Health [Category] COVID-19, [키워드] Asia Bangladesh Contagion country COVID-19 pandemic effective emergence Genetic genetic surveillance Genome genomic health system identify increase in measure MONITOR Mutation Occurrence public health public health emergency SARS-CoV-2 variant SARS-CoV-2 variants South Surveillance the disease the vaccine variants variants of concern virus [DOI] 10.1186/s41182-021-00360-w PMC 바로가기 [Article Type] Letter to the Editor
Interventions to control nosocomial transmission of SARS-CoV-2: a modelling studySARS-COV-2의 병원체 전염을 통제하기위한 중재 : 모델링 연구Research Article Published on 2021-08-272022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 변종, [키워드] absenteeism Analysis assumed baseline caused Contact tracing COVID-19 diagnostic diagnostic test Effect effective effective intervention effective interventions Effectiveness emergence First wave HCW HCWs healthcare healthcare worker Healthcare workers hospital hospital ward individual infected individual infected individuals Intervention effects less limit maintain measure Netherland Netherlands nosocomial Nosocomial transmission other variable pandemic Patient Personal protective equipment PPE pre-symptomatic proportion reduced Regular Reproduction number Result SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 variants Screening sensitivity Sensitivity analyses significantly supplementary material symptom onset symptomatic tested Transmissibility Transmission variant yielding [DOI] 10.1186/s12916-021-02060-y PMC 바로가기 [Article Type] Research Article
Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment회복기 혈장 치료를 받는 면역 저하된 숙주에서 여러 SARS-CoV-2 항체 탈출 변이체의 출현Research Article Published on 2021-08-252022-09-10 Journal: mSphere [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha anti-SARS-CoV-2 antibody B.1.1.7 B.1.351 B.1.617.2 Beta compromised immune status convalescent plasma Convalescent plasma therapy convalescent plasma treatment coronavirus COVID-19 pandemic Deletion deletions disease severity domain E484K Efficacy emergence escape Evidence evidence of Evolution FIVE genomic hosts hypothese hypotheses identify IgG immune escape mutants Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppressed Immunosuppression in vitro lentiviral Lineage lineages measure microevolution Multiple mutant mutants Mutation mutations N-terminal domain neutralization Neutralizing antibodies neutralizing antibody NTD observation over P.1 Patient Population Prolonged infection pseudovirus RBD RBD mutation RBD mutations RBD region Receptor-binding domain reduce reduced Region required respiratory S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selective pressure sequence serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein steroid Steroids Support susceptibility Swab the S protein therapy total Ig tracheal tracheal aspirate Transmissibility Transmission unique Vaccine variants variants of concern Viral viral evolution VoC VOCs [DOI] 10.1128/mSphere.00480-21 PMC 바로가기 [Article Type] Research Article
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York뉴욕에서 확인 후 SARS-CoV-2 B.1.526의 출현 및 확장Article Published on 2021-08-242022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody antibody resistance antigenic B.1.1.7 B.1.1.7 lineage B.1.526 Clinical use contribute contributed dominance E484K Efficacy emergence Extensive globe growth individual Iota less Lineage Microbiology monoclonal antibodies monoclonal antibody Mutation N501Y neutralization Neutralizing activity New York New York City other variant other variants plasma replaced reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant serum spike mutation Spike protein Spread spread of COVID-19 susceptible the SARS-CoV-2 the spike protein the United State therapeutic Transmission Transmission dynamics United States vaccinated individuals Vaccine variant variants Viral viral evolution Virology [DOI] 10.1038/s41586-021-03908-2 PMC 바로가기 [Article Type] Article
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptationSpike 유전자의 선택적 스윕은 SARS-CoV-2 인간 적응을 주도했습니다Article Published on 2021-08-192022-09-11 Journal: Cell [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive assays bat bats binding cellular receptor contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G D614G mutation domain emergence Evolution Genome glycosylation greater hACE2 higher affinity hosts human ACE2 human lung cell human lung cells human SARS-CoV-2 human-to-human transmission molecular molecular virology mutant Mutation Non-synonymous pandemic pangolins Positive selection predicted RBD related virus Replication reservoir SARS-CoV-2 selective selective sweep sequence severe acute respiratory syndrome Coronavirus Spike protein spillover sustained the Spike the spike protein Transmission variant viral adaptation wild-type [DOI] 10.1016/j.cell.2021.07.007 PMC 바로가기 [Article Type] Article
Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2SARS-COV-2의 알파 변이체에 감염된 고위험 환자 중에서 Bamlanivimab 단일 요법 후 E484K 돌연변이의 출현Article Published on 2021-08-192022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] Administered administration authorization B.1.1.7 B.1.1.7 variant bamlanivimab baseline belatacept clinically Complication COVID-19 COVID-19 diagnosis COVID-19 patient died E484K emergence Emergency Emergency use authorization Europe FIVE France high risk High-risk patients infused infusion IV injection kidney transplant males management median age monoclonal antibodies monoclonal antibody monotherapy multiple comorbidities mutant Mutation nasopharyngeal nasopharyngeal viral nosocomial outcome Patient patients Prevent resistance risk RT-PCR SARS-CoV-2 SARS-COV-2 infection Sequencing severe COVID-19 single dose the United State treated Treatment United States variant variants Viral were infected whole genome Whole genome sequencing [DOI] 10.3390/v13081642 PMC 바로가기 [Article Type] Article
The Emergence and Spread of Novel SARS-CoV-2 Variants새로운 SARS-CoV-2 변이체의 출현과 확산Public Health Published on 2021-08-022022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect Analysis ArcGIS B.1.1.7 B.1.351 caused changes in Characteristics Coronavirus-2 distribution E484K emergence Epidemiology frequencies Frequency Genotype GISAID immune response K417N Laboratory MONITOR mutant mutant frequencies Mutation mutations N501Y natural infection Neutralizing antibodies novel other variants P.1 prevalent reduce respiratory S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Spread subtype Vaccine variants Viral viral gene viral genes WGS whole genome Whole genome sequencing [DOI] 10.3389/fpubh.2021.696664 PMC 바로가기 [Article Type] Public Health
Genomic Surveillance and Phylodynamic Analyses Reveal the Emergence of Novel Mutations and Co-mutation Patterns Within SARS-CoV-2 Variants Prevalent in IndiaMicrobiology Published on 2021-07-292022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Analysis association clade collected country Course COVID-19 COVID-19 patient Critical emergence Evolution Genome sequencing genomic GISAID database identification India Infection Kolkata manifested Mutation mutation – genetics novel outcome overlap patients pattern performed phylodynamic Phylodynamic analyses prevalent profile SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence specific mutation Spread variant West whole-genome sequencing [DOI] 10.3389/fmicb.2021.703933 PMC 바로가기 [Article Type] Microbiology
A Possible Role of Remdesivir and Plasma Therapy in the Selective Sweep and Emergence of New SARS-CoV-2 VariantsReview Published on 2021-07-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Administered anti-spike antibodies Brazil changes characterized clinical trial convalescent plasma coronavirus COVID-19 COVID-19 pandemic elicited emergence Europe favor Genetic Hypothesis Immune escape Immunocompromised patient include Infection Lineage MONITOR monoclonal antibody multiple mutation mutants Mutation neutralizing antibody New new SARS-CoV-2 Occurrence Patient physician plasma therapy promoter recent Remdesivir replaced role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variants South Africa Spread Support the patient therapy treat Vaccine immunization variant variants viral mutation viral spike protein whole-genome sequencing [DOI] 10.3390/jcm10153276 PMC 바로가기 [Article Type] Review