Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV Analysis Antigen antigens applied Applying approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article
Characterization of antibody response to an epitope spanning the haemagglutinin cleavage site of H7N9 subtype avian influenza virus for the differentiation of infected and vaccinated chickensArticle Published on 2022-08-012023-06-22 Journal: Avian Pathology [Category] 조류인플루엔자, [키워드] Antibody Response DIVA epitope H7N9 subtype AIV HA cleavage site Serological tests [DOI] 10.1080/03079457.2022.2054308
Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles VLPs VOCs [DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article
Potential linear B-cells epitope change to a helix structure in the spike of Omicron 21L or BA.2 predicts increased SARS-CoV-2 antibodies evasionOmicron 21L 또는 BA.2의 스파이크에서 나선 구조로의 잠재적 선형 B 세포 에피토프 변화는 SARS-CoV-2 항체 회피 증가를 예측합니다Article Published on 2022-08-012022-09-11 Journal: Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] B-cell B.1.1.529 changed clade COVID-19 epitope Epitopes escape expected explain finding flexibility Health Organization human monoclonal antibodies linear Mutation notable omicron physiochemical properties physiochemical property platform Potential predict SARS-CoV-2 SARS-CoV-2 antibody spike spike mutation Spike protein stability the spike protein Vaccine variant variants VoC World Health Organization [DOI] 10.1016/j.virol.2022.06.010 PMC 바로가기 [Article Type] Article
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, [키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization [DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article
SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infectionBA.2.12.1, BA.4 및 BA.5는 Omicron 감염에 의해 유발된 항체를 탈출합니다.Comparative Study Published on 2022-08-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody bebtelovimab binding affinities binding affinity booster cilgavimab clone comparison coronavirus cross-reactive distribution Efficiency elicited enzyme epitope Epitopes escape mutation evade exhibiting humoral Humoral immunity immune memory individual induce Infection L452R Lineage mechanism Mutation mutations neutralization neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variants plasma profile recall receptor Receptor binding Receptor-binding domain referred to respiratory resulting sarbecovirus SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies Spike mutant spike mutants Spike protein Spike proteins the receptor-binding domain therapeutic Transmissibility vaccination Vaccine variant variants Viral viral spike protein wild-type WT SARS-CoV-2 [DOI] 10.1038/s41586-022-04980-y PMC 바로가기 [Article Type] Comparative Study
Generation and characterization of humanized synergistic neutralizing antibodies against SARS-CoV-2SARS-CoV-2에 대한 인간화 시너지 중화 항체의 생성 및 특성화Article Published on 2022-08-012022-09-12 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody binding chimeric clinical therapy Combination coronavirus coronavirus disease COVID-19 epitope exhibited Generation global public health humanized humanized antibodies humanized neutralizing antibody Local neutralization activity Neutralizing Neutralizing activity neutralizing antibody Protein pseudovirus pseudovirus system RBD recognize SARS-CoV-2 SARS-CoV-2 pseudovirus single-chain antibody synergistic synergistic neutralizing activity. the receptor-binding domain the SARS-CoV-2 [DOI] 10.1002/jmv.27801 PMC 바로가기 [Article Type] Article
Production and characterization of chimeric SARS-CoV-2 antigens based on the capsid protein of cowpea chlorotic mottle virus동백색 반점 바이러스의 캡시드 단백질을 기반으로 하는 키메라 SARS-CoV-2 항원의 생산 및 특성화Article Published on 2022-07-312022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] absence Antigen antigens BALB/c mice characterized chimeric Chimeric protein clinical evaluation COVID-19 pandemic Cowpea cultures develop E. coli Efficacy epitope Epitopes expressed expression full-length S protein Humoral response IgG antibody IgG antibody titer immunogenic Inclusion induce interfere mutant offer Pathogens plant plant virus Plant virus. Production Protein purified recognize resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein spike Spike protein subunit Subunit vaccine subunit vaccines Support the SARS-CoV-2 the vaccine Vaccine vaccine candidate vaccine candidates vaccine platform virus VLP VLPs [DOI] 10.1016/j.ijbiomac.2022.06.021 PMC 바로가기 [Article Type] Article
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy임신 및 영아기 mRNA 백신 제품 및 기능성 항체의 태반을 통한 전달 평가Article Published on 2022-07-302022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody antibodies antibody binding Blood Cohort Critical Effectiveness epitope evaluate Evidence functional IgG immunoprecipitation individual infancy mRNA mRNA vaccine neutralizing antibody Newborn persist Placenta placental Pregnancy Protective antibody Protein provided SARS-CoV-2 SARS-CoV-2 vaccination Sequencing spike tissue transfer transferred vaccination [DOI] 10.1038/s41467-022-32188-1 PMC 바로가기 [Article Type] Article