A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver diseaseMitochondrial Amidoxime Reducing Component 1 유전자의 missense 변이와 간 질환에 대한 보호Research Article Published on 2020-04-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Alanine Alanine transaminase alkaline phosphatase allele Blood blood cholesterol level Blood level blood levels carrier carriers cause of death cholesterol cirrhosis coding variant cohorts component computed tomographic Control death deficiency eight enzyme exhibit fat Fatty liver Genetic genetic finding genetic findings hepatic fat homozygous identify individual LDL cholesterol liver Liver disease liver enzyme loss-of-function MARC1 Missense missense variant mitochondrial phosphatase potential therapeutic target predicted PROTECT reduced reduced risk Total cholesterol variant [DOI] 10.1371/journal.pgen.1008629 PMC 바로가기 [Article Type] Research Article
Synergistic action of the transcription factors Krüppel homolog 1 and Hairy in juvenile hormone/Methoprene-tolerant-mediated gene-repression in the mosquito Aedes aegypti유년 호르몬에서 전사 인자 Krüppel homolog 1과 Hairy의 시너지 작용/모기 Aedes aegypti에서 메토프렌 내성 매개 유전자 억제Research Article Published on 2019-10-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition acting Activation addition adult females Aede assays binding binding site Blood co-regulated cohorts Complete complexity demonstrated downstream expression Factor Factors fat female function Gene Expression Genes Hairy hierarchy homolog hormone human diseases immature implicated information Insects Interaction Juvenile knockdown Krüppel luciferase maturation Methoprene Mosquito pathogen transmission pathway receptor regulate regulated Regulatory regulatory region reporter repressed repression reproduction reproductive required Research significantly stages subsequent synergistic synergistic action synergistic fashion target gene Target genes the mosquito transcription factor transcriptional transcriptional repressor transcriptomic analysis vector Zinc [DOI] 10.1371/journal.pgen.1008443 PMC 바로가기 [Article Type] Research Article
Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease항염증성 microRNA-146a는 식이 유발 대사 질환으로부터 생쥐를 보호합니다Research Article Published on 2019-02-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adipose Adipose tissue Adiposity administration blockade blood glucose cellular cellular metabolism cellular respiration chronic inflammation Combination contribute Control controls creating Critical demonstrated develop Diabetic diabetic patient diabetic patients diet dysregulated Evidence expressed expression Factor fat genetics Glucose Glycolysis Human identifying Immune cell immune cells increase in Inflammation inflammatory function inflammatory gene inflammatory genes inflammatory pathways influence inhibitor Interaction investigated involved Macrophage macrophages mechanism metabolic disease metabolic pathway metabolic pathways metabolic processe metabolic processes metabolism mice microRNA miR-146 miRNA mTOR NF-κB NF-κB activation obese obesity pathway phenotype Phenotypes potential therapeutic target Prevent Pro-inflammatory genes PROTECT protective role provide Rapamycin reduced regulate regulated Regulatory represse Research RNA-sequencing shown Symptom tissue tissue macrophage Traf6 weight gain wild-type [DOI] 10.1371/journal.pgen.1007970 PMC 바로가기 [Article Type] Research Article
A case of porphyria cutanea tarda of the liver exhibiting multifocal macrovesicular steatosis in the background of microvesicular steatosis, probably caused by uneven iron accumulationCase Reports Published on 2017-07-012023-06-19 Journal: Abdominal radiology (New York) [Category] B형 간염, [키워드] fat iron liver MRI Porphyria cutanea tarda. [DOI] 10.1007/s00261-017-1056-0 [Article Type] Case Reports
Adipose Tissue: A Safe Haven for Parasites?article Published on 2017-04-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] adipocyte Adipose tissue fat Lipid malaria pathogen Trypanosoma [Article Type] article
Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어Research Article Published on 2016-05-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound [DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article
Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial바로 사용할 수 있는 땅콩 기반 치료 식품을 매일 섭취하면 무지방 질량이 증가하고 빈혈 상태가 개선되지만 HIV/AIDS 감염자의 아연 상태에는 영향을 미치지 않습니다. 무작위 대조 시험Research Article Published on 2016-01-042022-08-09 Journal: BMC Public Health [Category] 임상, [키워드] adjusted Admission affected AIDS Anemia anemic anemic status ART atomic absorption spectrometry Bio-Impedance Analysis Body body composition body fat body weight both groups clinical trial comparable Concentration conducted Control control group Controlled Controlled clinical trial CRP Daily daily recommended intake deficiency discharge energy fat Fat free mass fat-free mass food group hemoglobin HIV/AIDS Hospitalized Improving Individual dietary Infection iron Malnutrition measure muscle mass on admission patients percentage body fat plasma plasma zinc concentration PLWH positive Randomized controlled trial Randomly ready-to-use therapeutic food receive Recommended Dietary Allowances Registered remained Result Senegal severe malnutrition significantly standard hospital diet status sub-Saharan Africa the patient therapeutic Therapeutic food Treatment was determined was measured were measured Zinc zinc deficiency α1-AGP [DOI] 10.1186/s12889-015-2639-8 PMC 바로가기 [Article Type] Research Article
A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity타고난 면역에 대한 결과와 함께 전사 조절에서 RBF1 및 dCAP-D3의 공유 역할Research Article Published on 2012-04-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation affected Alter AMP AMPs antimicrobial peptide Author Bacteria Bacterial infection Bacterial pathogens Cell cell cycle cell cycle arrest cell cycle gene cell cycle genes chromatin chromatin condensation classic Cluster condensation Condensin consequence conserved decrease DNA Drosophila Drosophila melanogaster expression fat function Gene gene cluster gene clusters Genes homolog homologs human cell human cells identify immune response immune system in vivo induce Infection Innate innate immune genes Innate immunity Interaction mitosis mitotic Pathogens peptide pRB previous study promote Protein Proteins RBF1 Region regulate regulated Regulation repress retinoblastoma retinoblastoma protein role shown subset subunit suggested transcript Transcription Tumor tumor suppressor undergo unique [DOI] 10.1371/journal.pgen.1002618 PMC 바로가기 [Article Type] Research Article