frequencies – Page 12 – Communicable Diseases Research

SARS-CoV-2 genomic variations associated with mortality rate of COVID-19

Article

Published on 2020-07-222022-10-04
Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법,

[키워드] Affect analyses association caused Cluster Clustering conducted coronavirus disease correlation country COVID-19 deaths Factor fatality Fatality rate frequencies Frequency Genetic genomic variation Genotype global pandemic Hierarchical HLA HLA alleles Host Immunogenetics independent infected cases Infection investigated Linkage disequilibrium mortality rate mutant Mutation number of infected ORF1ab outbreak positive correlation S protein SARS-CoV-2 SARS-CoV-2 genome sequence SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 sequence severity of COVID-19 significantly susceptibility variant variants
[DOI] 10.1038/s10038-020-0808-9 PMC 바로가기 [Article Type] Article

Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

Research

Published on 2020-07-132022-10-31
Journal: The Egyptian Heart Journal [Category] COVID-19,

[키워드] Admission affected cardiovascular cardiovascular disease children Comorbidity Concordance conducted Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CVD database Deceased develop Diabetes Mellitus disease electrocardiographic elevated frequencies Frequency funnel plots Health high-risk patient hypertension identify Inflammatory inflammatory biomarkers Injury intensive care interleukin-6 Kawasaki disease less mechanism Meta-analysis MIS-C Mortality occurred Odds ratio pandemic pathologic Patient Result Risk factors risk stratification severity Shock SMD standardized mean difference statistically significant Survivors syndrome systematic review the disease therapy Treatment Triage troponin
[DOI] 10.1186/s43044-020-00075-z PMC 바로가기 [Article Type] Research

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

Article

Published on 2020-05-042022-10-31
Journal: Cell Discovery [Category] COVID-19,

[키워드] affected Analysis antibody B cells BCR caused CD14 CD4 CD8 Cell change classical Course COVID-19 COVID-19 patient COVID-19 patients early recovery Evidence expressed frequencies Gene Expression greater hospital discharge identification IGHV3-15 IGHV3-23 IGHV3-30 IGHV3-7 IGKV3-11 IL-18 IL-1β IL-2 IL-4 IL1β Immune cell immune signature immunology indicated Inflammatory inflammatory gene inflammatory storm isotype M-CSF Mechanisms of disease monoclonal monocyte mononuclear cell naïve B cell Patient Peripheral blood Plasma cell predicted provide reported SARS-CoV-2 Sequencing Signaling significantly single-cell Single-cell RNA sequencing specificity subset T cell target gene TNFSF13 transcriptional change Treatment Vaccine Vaccine development virus
[DOI] 10.1038/s41421-020-0168-9 PMC 바로가기 [Article Type] Article

Risk Assessment of Novel Coronavirus COVID-19 Outbreaks Outside China

Article

Published on 2020-02-192022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy

프로테아제 억제제 단독 요법의 PIVOT 시험에서 HIV-1 프로테아제의 차세대 시퀀싱

Article

Published on 2018-04-012022-09-06
Journal: Journal of Clinical Virology [Category] Communicable Disease,

[키워드] Algorithm Antiretroviral therapy clinically Combination combination therapy Coverage described drug drug susceptibility Evidence examined frequencies Frequency frozen plasma Highlights HIV HIV-1 Laboratory leads Local low frequency median time Median viral load methodology monotherapy Mutation mutations next generation sequencing NGS objective Patient patients performed phenotypic plasma sample predict predicted Primary outcome protease Protease inhibitor Public Health England randomisation randomised reported resistance Result Ritonavir Sanger sequencing selected Sequencing Stanford Study design study drug suppressed susceptibility tested the median threshold Trial variant Viral Viral load was performed
[DOI] 10.1016/j.jcv.2018.02.003 PMC 바로가기 [Article Type] Article

Genome-wide analysis of codon usage bias in Bovine Coronavirus

Research

Published on 2017-06-172022-10-28
Journal: Virology Journal [Category] Coronavirus,

The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

인간 표현형 온톨로지: 일반 및 희귀 질병의 의미적 통합

Article

Published on 2015-07-022022-08-07
Journal: American Journal of Human Genetics [Category] 유전자 메커니즘,

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

고위험군 분리가 두개내 동맥류에 걸리기 쉬운 저주파 변이를 나타냅니다

Research Article

Published on 2014-01-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Aneurysm arteries Artery association Author balloon bleeding bottleneck events Brain Case-control cause compared complex complex diseases contribute Control controls develop different disease effect size effect sizes European population events explain explained Families Finn Finnish Finns FIVE fraction frequencies Frequency genetic background Genetic variant Genetic variation genotype imputation GWAS hemorrhage heritability identify incidence Inconclusive Intracranial intracranial aneurysms isolate isolates knowledge lead life-threatening loci locus low frequency MAF matched controls Netherland Netherlands Patient Population populations rare variant Rare variants related replicated rupture saccular stroke Study design Subarachnoid subarachnoid hemorrhage susceptibility tested utility variant variants
[DOI] 10.1371/journal.pgen.1004134 PMC 바로가기 [Article Type] Research Article

Loss and Recovery of Genetic Diversity in Adapting Populations of HIV

HIV 집단 적응에 있어 유전적 다양성의 상실과 회복

Research Article

Published on 2014-01-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accompanied arise Author cells change confidence interval different discrepancies Diversity drug resistance effective estimate event Evolution fixation fixed found frequencies Frequency frequency of occurrence Genetic genetic diversity greatly reduce hitchhiking HIV HIV population implication IMPROVE increases in infected cell infected cells infected patient infected patients Loss mean much higher much lower multiple mutation multiple mutations Mutation mutations Neutral no effect Non-synonymous number of infected observation observé occur Occurrence Patient Population Population size reduce reduction reduction in resistance mutations second selective sweeps sequence Spread supply synonymous the patient Treatment strategies Viral viral particle virus
[DOI] 10.1371/journal.pgen.1004000 PMC 바로가기 [Article Type] Research Article

VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses

Research

Published on 2013-12-112022-10-30
Journal: Journal of Translational Medicine [Category] Coronavirus,