Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus InfectionImmunology Published on 2022-01-112022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis antibody blood plasma caused coronavirus correlated cross-reactive antibodies cross-reactive antibody domain elderly epitope function functions group had no IgG antibody Korean mechanism neutralization neutralized Neutralizing Neutralizing activity neutralizing effect Novel coronavirus outbreak plasma plasma sample plasma samples positive pre-pandemic samples pseudotype receptor binding domain (RBD) role Sample SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 S1 shown significantly the SARS-CoV-2 viral infection Viral pneumonia virus was used [DOI] 10.3389/fimmu.2021.813240 PMC 바로가기 [Article Type] Immunology
Oral cavity infection by the SARS-CoV-2: emphasizing the essence of masking and peptide therapeuticsCorrespondence Published on 2022-01-102022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] ACE2 ACE2 receptor binding blood pressure homeostasis carried cathepsin L cellular cleavage conformational change COVID-19 cytoplasm disease epithelial function functions glycoprotein healthcare high expression level high risk host’s body human ACE2 receptor Infection information inhibit nucleocapsid oral cavity oral mucosa other proteases peptide Protease inhibitor Protein proteolytic cleavage Regulation Saliva SARS-CoV-2 secretion supplementary material therapeutic TMPRSS2 viral loads viral spike [DOI] 10.1186/s43042-022-00213-z PMC 바로가기 [Article Type] Correspondence
The adaptation of SARS-CoV-2 to humansSARS-CoV-2의 인간 적응Review Published on 2022-01-102022-09-10 Journal: Memórias do Instituto Oswaldo Cruz [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation adaptive adaptive evolution addition antibodies anticipated autophagy Cell coronavirus death Defense Depletion escape Evidence functions Host host cell host cells Human Immunity immunogenic impairment include inhibiting interferon lymphocyte Mitochondria motifs Mutation mutation and variants occurred other coronaviruses overcome process of adaptation replicate resource respiratory respiratory tract SAR-CoV-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus triggering Usage Viral Viral RNA viral RNA detection virus [DOI] 10.1590/0074-02760210127 PMC 바로가기 [Article Type] Review
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
BPC 157 as Potential Treatment for COVID-19Research article Published on 2022-01-012022-10-05 Journal: Medical Hypotheses [Category] 임상, 치료법, [키워드] activated acute respiratory distress animal model Anti-inflammatory BPC 157 cardiovascular complications caused China Clinical management clinical trial Clinical use Comorbidity complementary Complication coronavirus disease Course COVID-19 COVID-19 patient Critical Cytoprotection demonstrated Effect effective endothelial Endothelial cell Endothelial cells (ECs) Endothelial nitric oxide synthase (eNOS) examined explain functions Human immune response IMPROVE Liver damage multi-organ failure neurological nitric oxide organ injury organ system outbreak patients peptide Potential proinflammatory Prophylactic provoke reduced syndrome the disease thrombotic tissue repair Treatment Vascular vascular disease [DOI] 10.1016/j.mehy.2021.110736 [Article Type] Research article
Modelling behaviors relevant to brain disorders in the nonhuman primate: Are we there yet?Review article Published on 2022-01-012022-10-05 Journal: Progress in Neurobiology [Category] 비임상, [키워드] Analysis approach ASDautism spectrum disorder Autism Spectrum Disorder Brain Clinical outcome cognitive complex Critical disorder disorders dlPFCdorsolateral prefrontal cortex dorsolateral prefrontal cortex Examining experiment functions illnesses IMPROVE in vivo macaques mechanism medial prefrontal cortex mPFCmedial prefrontal cortex neurological Neuropsychiatric NHP NHPnonhuman primate NHPs nonhuman primate OFCorbitofrontal cortex offer orbitofrontal cortex PFCprefrontal cortex Prefrontal cortex probe provided RDoCResearch Domain Criteria recent reproducibility Research Research Domain Criteria Symptom translation unique ventrolateral prefrontal cortex ventromedial prefrontal cortex vlPFCventrolateral prefrontal cortex vmPFCventromedial prefrontal cortex [DOI] 10.1016/j.pneurobio.2021.102183 [Article Type] Review article
Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach전통 인도 의학에 의한 COVID-19에 대한 면역 체계의 활성화 메커니즘 이해: 네트워크 약리학 접근Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] ACE activating acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alarm Algorithm alternative medicine approach approved betulinic acid biological process cathepsin cathepsin B cathepsin L cellular clinical trials Compound compounds coronavirus 2 COVID-19 COVID-19 infection determine disease DPP4 drug drug design drug target effective EGFR Emergency use enrichment analyses enrichment analysis Evolution functions gene-gene interaction globe HDAC2 identify IL6 immune system Interaction involved JACOM Kabasura kudineer mechanism medication Medicine molecular docking studies Molecular docking study molecular functions Mutation network network pharmacology Nilavembu kudineer pandemic pathway Pathways performed phenyl plant plants Potential treatment predict raising respiratory RIPK1 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects target targets the SARS-CoV-2 Traditional Traditional Indian Medicine. Transmission transmissions treat treating COVID-19 understanding Vaccine VEGFA Virtual screening was used [DOI] 10.1016/bs.apcsb.2021.11.007 PMC 바로가기 [Article Type] Article
The Cognitive Consequences of the COVID-19 Pandemic on Members of the General Population in Italy: A Preliminary Study on Executive InhibitionArticle Published on 2021-12-292022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] alteration Anxiety association characterized cognitive cognitive functions conditions consequence COVID-19 COVID-19 pandemic disorder evaluated executive expressed functions General population impairment increasingly inhibition Italian population member pandemic participated Population post-traumatic post-traumatic stress symptom Post-traumatic stress symptoms preliminary finding previous study Psychological reported responses virus worsening [DOI] 10.3390/jcm11010170 PMC 바로가기 [Article Type] Article
COVID-19 in a Patient With Severe Eosinophilic Asthma on Benralizumab Therapy: A Case Report and Review of LiteratureAllergy/Immunology Published on 2021-12-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect antiviral activity Asthma Asymptomatic COVID-19 benralizumab clinical status contribute coronavirus coronavirus disease Course COVID-19 COVID-19 patients COVID-19 prognosis cytotoxicity deplete Deterioration develop eosinophil Eosinophilic functions IL-5 immunoregulation Infection inflammatory reaction literature literature review modulation monoclonal antibody Patient positive report review SARS-CoV-2 Severe asthma severity of COVID-19 tested the disease therapy [DOI] 10.7759/cureus.20644 PMC 바로가기 [Article Type] Allergy/Immunology
Leptin in the Respiratory Tract: Is There a Role in SARS-CoV-2 Infection?Physiology Published on 2021-12-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Affect bidirectional coronavirus coronavirus disease COVID-19 Evidence expressed functions gut microbiota Health immune immune system Immunity interfere involved Leptin Long lung metabolism microbiota modulating obesity organs pathophysiology peripheral tissue pleiotropic protective immunity pulmonary infections receptor respiratory respiratory tract role SARS-CoV-2 SARS-CoV2 susceptibility the gut-lung axis tissue homeostasis [DOI] 10.3389/fphys.2021.776963 PMC 바로가기 [Article Type] Physiology