genetic variants – Page 12 – Communicable Diseases Research

Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile

칠레에서 SARS-CoV-2의 유전적 변이 및 계통의 지리적 분포

Public Health

Published on 2020-09-222022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 변종,

Genetic grouping of SARS-CoV-2 coronavirus sequences using informative subtype markers for pandemic spread visualization

전염병 확산 시각화를 위한 유익한 하위 유형 마커를 사용한 SARS-CoV-2 코로나바이러스 서열의 유전적 그룹화

Research Article

Published on 2020-09-172022-08-13
Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘,

[키워드] added addition Analysis Applying Asia Author base cause Clustering complementary confirmed case Containment strategy COVID-19 COVID-19 pandemic D614G detect disease spread distribution downstream analyses effective efficient epidemiological studies Epidemiological study Europe followed by founder effect Frequency frequency analysis generate Genetic Genetic variant genetic variants Geographic distribution GISAID GISAID database Github highlight identify include increasingly individuals infected individual infected individuals information Local Major marker modeling Mutation New York Nextstrain Novel coronavirus nucleotide nucleotides ORF1ab outbreak pandemic Phylogenetic prevalent researcher responsible SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 evolution SARS-CoV-2 pandemic SARS-CoV-2 sequence SARS-CoV-2 sequences selection pressure sequence sequenced spatiotemporal Spike protein Spread subtype Subtypes temporal dynamics the spike protein the United State The United States therapeutic threshold United States utility Vaccine variant Viral viral dynamics viral genome viral genomes Viral transmission virus Visualization website
[DOI] 10.1371/journal.pcbi.1008269 PMC 바로가기 [Article Type] Research Article

Opioid and neuroHIV Comorbidity – Current and Future Perspectives

아편유사제 및 neuroHIV 동반 질환 – 현재 및 미래 전망

Review

Published on 2020-09-022022-09-10
Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, 변종, 유전자 메커니즘,

[키워드] μ-Opioid receptor (OPRM1) Antiretroviral therapy Astrocyte blood-brain barrier Brain breakdown Buprenorphine C-C motif chemokine receptor 5 (CCR5) cellular Central nervous system chemokine Clinical studies clinical study CNS Comorbidity Compound consequence COVID-19 Critical current Cytochrome P450 3A4 (CYP 3A4) disease disorder drugs Endogenous opioid system of peptides and receptors experimental models expression focus functional Functional selectivity/biased agonism Future gene product genetic variants hand HIV HIV-1 HIV-associated neurocognitive disorders Host Human immunodeficiency virus immunodeficiency virus include increase Interaction key consideration key considerations Maladaptive neuroplasticity mechanism Methadone methodology microglia molecular National neuroHIV Neurovascular not seen Oligodendroglia opiate opioid opioids P-glycoprotein Pathogenesis pathophysiologic pathophysiology penetration Pro-brain-derived neurotrophic factor (pro-BDNF) Prognosis progression Protein question recent receptor severity Synaptodendritic degeneration tight junction unique variants with HIV
[DOI] 10.1007/s11481-020-09941-8 PMC 바로가기 [Article Type] Review

COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells

Article

Published on 2020-08-272022-10-31
Journal: Genes [Category] COVID-19, MERS,

Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity

Article

Published on 2020-08-192022-10-04
Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘,

[키워드] ACE2 acute respiratory syndrome Amino acid Analysis analyzed angiotensin-converting enzyme 2 annotation arginine Asia Belgium Case fatality rate circulating coding sequence Complete Computational biology and bioinformatics conserved Coronavirus-2 COVID-19 pandemic Deletion domain effective England epidemiological data epitope Europe European Evolution Frame France Frequency genetic variants genetics Genome genome sequence genomic GISAID database globe heterogeneous implication Interaction Italy lysine Microbiology Mutation Netherlands neutralizing antibody North America nucleotide ORF10 ORF1ab ORF7a pandemic polyprotein Prophylaxis Protein Proteins RBD remained reported residue responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus strain sequence Shanghai Spain Substitution the SARS-CoV-2 genome Variation Viral protein virus strains
[DOI] 10.1038/s41598-020-70812-6 PMC 바로가기 [Article Type] Article

Pharmacogenomics of COVID-19 therapies

Review Article

Published on 2020-08-182022-10-04
Journal: NPJ Genomic Medicine [Category] 바이오마커, 유전자 메커니즘, 임상, 치료제,

[키워드] ABCC2 adverse effects Alter association Baricitinib Chloroquine clinical Concentration coronavirus disease Corticosteroids COVID-19 COVID-19 patient CYP2C8 CYP2D6 drug Effect Efficacy Efficacy and safety Evidence Favipiravir FDA food genetic marker Genetic markers genetic variants global pandemic Hemolysis high mortality Hydroxychloroquine hydroxychloroquine/chloroquine information inhibitors interferon Interferon beta-1b labeling liver morbidity notable other variants pharmacogenetics pharmacogenomics QT prolongation Remdesivir ribavirin risk ruxolitinib searched SLC28A2 SLC29A1 SLCO1A2 SLCO1B1 Therapies therapy Tocilizumab Toxicity variant viral infection website
[DOI] 10.1038/s41525-020-00143-y PMC 바로가기 [Article Type] Review Article

Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

서부 케냐 비히가 고원에서 어린이의 파르시파룸 말라리아에 대한 혈액형, 포도당-6-인산 탈수소효소 및 헤모글로빈 유전형의 영향

Research Article

Published on 2020-07-092024-08-11
Journal: BMC Infectious Diseases [Category] 말라리아,

[키워드] children genetic variants malaria Western Kenya
[DOI] 10.1186/s12879-020-05216-y PMC 바로가기 [Article Type] Research Article

The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19

Review article

Published on 2020-06-252022-10-05
Journal: Molecular Therapy [Category] 유전자 메커니즘,

[키워드] ACE ACE2 ACE2 protein ACE2 receptor ACEi acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-renin system antihypertensive drugs antihypertensive medication ARB ARBs association binding blood pressure blood pressure homeostasis coronavirus coronavirus disease COVID-19 Critical debatable Deleterious Effectiveness evaluate examined expression face Genetic Genetic variant genetic variants host cell hypertension infected with SARS-CoV-2 Infection involved mechanism modulate modulating mortality rate Patient populations question receptor reducing risk role SARS-CoV-2 susceptibility therapy virus
[DOI] 10.1016/j.omtm.2020.06.017 [Article Type] Review article

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

Research Paper

Published on 2020-06-152022-10-28
Journal: Aging (Albany NY) [Category] COVID-19,

Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort

완전 모유 수유는 유전적으로 민감한 어린이의 체질량 지수 증가를 약화시킬 수 있습니다. ALSPAC 코호트의 종단 연구

Research Article

Published on 2020-06-112022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 95% CI adiposity peak adiposity rebound Adolescence age allele ALSPAC Analysis attenuate Birth BMI Breastfeeding childhood children Cohort composed Critical decrease early childhood EBF evaluated exclusive breastfeeding explain Factors Genetic genetic factors genetic risk genetic risk score genetic variability Genetic variant genetic variants Genome-wide association study genome-wide significant growth GRS GWAS GWASs increase in influence Intervention large-scale genome-wide association studies life longitudinal longitudinal study modulating non-communicable diseases obesity overweight parent parents pediatric Predictive Previous studies previous study priority proportion quartile recent reduce reducing risk shown significantly SNP susceptible variant was used while
[DOI] 10.1371/journal.pgen.1008790 PMC 바로가기 [Article Type] Research Article