Multisystem Inflammatory Syndrome in Children – Initial Therapy and Outcomes소아의 다기관 염증 증후군 - 초기 치료 및 결과Comparative Study Published on 2021-07-012022-09-12 Journal: The New England Journal of Medicine [Category] Fulltext, MERS, 진단, [키워드] 95% CI 95% confidence interval age Analysis analyzed baseline biologic cardiovascular dysfunction center children component Control demographic characteristics died Effectiveness evaluated Fever glucocorticoid Glucocorticoids healthy hospital immune immunomodulatory immunomodulatory medication immunomodulatory therapy Inflammatory initial Inpatient intravenous lower risk median age MIS-C occurred outcome Patient patients Primary outcome Probability receiving resulting risk second dose secondary severity Shock surveillance data syndrome therapy Treatment vasopressors ventricular dysfunction Weighting [DOI] 10.1056/NEJMoa2102605 PMC 바로가기 [Article Type] Comparative Study
Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysisResearch article Published on 2021-07-012022-10-05 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] adverse effects Analysis Antibiotics antiparasitic Antiviral antiviral drug antiviral drugs antiviral medicine approach aquatic environment Chloroquine COVID-19 COVID-19 pandemic Dexamethasone Ecotoxicity read-across Effect emission Environmental impact Environmental risk EPA Glucocorticoids group Guidance highlight Human medicines identify in vitro data information Ivermectin medication offer pharmacokinetic pharmacological Potential treatment Prophylactic Quantitative resulting retrieved risk therapeutic Treatment [DOI] 10.1016/j.scitotenv.2021.146257 [Article Type] Research article
Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry류마티스 질환이 있는 사람의 COVID-19 관련 사망과 관련된 요인: COVID-19 Global Rheumatology Alliance 의사 보고 레지스트리의 결과Article Published on 2021-07-012022-09-12 Journal: Annals of the rheumatic diseases [Category] Fulltext, SARS, 진단, [키워드] 1.26 95% CI age Alliance antirheumatic agents association Autoimmune Autoimmune diseases cardiovascular disease caution Comorbidities covariate COVID-19 COVID-19-related death Cyclophosphamide death determine died disease Disease activity Disease diagnosis dosage dosages Epidemiology Factor female glucocorticoid Glucocorticoids Health Health care higher odd highlight hypertension Immunosuppressant immunosuppressants Lung disease Male sex medication medications methotrexate monotherapy multivariable logistic regression Older age Other outcome outcome assessment Patient Primary outcome receiving required Rheumatic diseases rituximab Sex smoking status stratified sulfasalazine [DOI] 10.1136/annrheumdis-2020-219498 PMC 바로가기 [Article Type] Article
Inferring molecular mechanisms of dexamethasone therapy in severe COVID-19 from existing transcriptomic data기존 전사체 데이터에서 중증 코로나19 환자에서 덱사메타손 치료의 분자 메커니즘 추론Article Published on 2021-07-012022-09-11 Journal: Gene [Category] 유전자 메커니즘, 치료제, [키워드] Analysis anti-inflammatory activity benefit bioinformatic analysis blood immune cell blood immune cells Cell cellular coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines Dexamethasone differentially expressed gene Differentially expressed genes drug Effectiveness experimental evidence expression Gene Expression Gene regulation glucocorticoid Glucocorticoids hyperinflammatory state IFN-α IFN-β IFN-γ IL-1α IL-1β IL-6 IL-6 pathway IL-6 signaling immune cells Inference inferences Inflammation lung mechanism molecular mechanism Mortality observation opposite pathway proof proof of concept Randomized controlled trial Receptor binding regulated Regulation required reveal severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients shown Signaling signature Support the disease therapeutic therapeutic effect therapy TNF- α Transcriptome transcriptomic data treated Treatment [DOI] 10.1016/j.gene.2021.145665 PMC 바로가기 [Article Type] Article
High Prevalence of Active Tuberculosis in Adults and Children with Idiopathic Inflammatory Myositis as Compared with Systemic Lupus Erythematosus in a Tuberculosis Endemic Country: Retrospective Data Review from a Tertiary Care Centre in Indiaarticle Published on 2021-06-302024-09-02 Journal: Mediterranean Journal of Rheumatology [Category] 대상포진, [키워드] dermatomyositis Glucocorticoids India infections Lupus myositis Tuberculosis [DOI] 10.31138/mjr.32.2.134 PMC 바로가기 [Article Type] article
Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?중증 COVID-19에 대한 덱사메타손: 세포 및 분자 수준에서 어떻게 작용합니까?Review Published on 2021-06-232022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] accompanied activity anti-inflammatory property Bacterial sepsis cause caused characteristic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 develop Dexamethasone Diseases effective encoding proteins facilitate glucocorticoid glucocorticoid dexamethasone glucocorticoid receptor (GR) Glucocorticoids host cell Hypothesis hypothetical impacted infected cells Infection Infectious diseases Inflammation Influenza influenza pneumonia Innate immunity interfere life-threatening Local mechanism modulated modulating non-infected not affect pathologic Pneumonia potential molecular Protein Replication reported respiratory Respiratory failure respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection Sepsis Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe COVID-19 severe respiratory syndrome significantly steroid systemic inflammation Treatment type I interferons (IFNs) unique Viral Viral diseases viral replication virus viruses work [DOI] 10.3390/ijms22136764 PMC 바로가기 [Article Type] Review
SARS-CoV-2-Induced Multisystem Inflammatory Syndrome in a Young Adult: Case ReportCovid-19 Published on 2021-06-202022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] Atypical clinical feature COVID-19 criteria Cytokine storm Glucocorticoids healthy heart failure high mortality HLH Hyperinflammatory immunoglobulins Inflammatory macrophage activation syndrome male MIS Multiorgan Multisystem inflammatory syndrome overlapping potentially life-threatening report SARS-CoV-2 SARS-COV-2 infection Shock syndrome therapy treated Volume [DOI] 10.1007/s42399-021-00998-x PMC 바로가기 [Article Type] Covid-19
Use of glucocorticoids and azithromycin in the therapy of COVID-19Review Published on 2021-06-042023-06-15 Journal: Pharmacological Reports [Category] MERS, SARS, [키워드] Antibiotics COVID-19 Glucocorticoids SARS-CoV-2 [DOI] 10.1007/s43440-021-00286-4 PMC 바로가기 [Article Type] Review
A case report of acquired hemophilia following COVID-19 vaccineCase Reports Published on 2021-06-012023-06-23 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 신종인플루엔자, [키워드] Glucocorticoids hemophilia A hemorrhage immune system Immunosuppression [DOI] 10.1111/jth.15291 PMC 바로가기 [Article Type] Case Reports
Perspectives on glucocorticoid treatment for COVID-19: a systematic reviewCOVID-19에 대한 글루코코르티코이드 치료에 대한 전망: 체계적인 검토Article Published on 2021-06-012022-09-11 Journal: Pharmacological Reports [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome ADRS age all the inclusion criteria ARDS changes clinical status clinical trials commercialization coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 patients database described Dexamethasone English geographic location Glucocorticoid treatment Glucocorticoids heterogeneity inclusion criteria infected with SARS-CoV-2 Longitudinal studies longitudinal study Methylprednisolone Mortality nonrandomized clinical trial observational study pandemic Pandemics participant Participants Patient pharmacological treatment radiological Research respiratory distress Respiratory distress syndrome retrospective RT-PCR SARS- CoV-2 SARS-CoV-2 screened selected Sex Spanish syndrome systematic review Treatment Vaccine Viral pneumonia Viremia was done was related [DOI] 10.1007/s43440-021-00225-3 PMC 바로가기 [Article Type] Article