A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)SARS-CoV-2(COVID-19)에 감염되어 침습적 기계 환기 없이 병원에 입원한 환자에서 이카티반트의 효능과 안전성을 평가하기 위한 다기관, 공개 라벨, 무작위, 개념 증명 II상 임상 시험: 연구 프로토콜(ICAT-COVID)Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 ACE2 acute respiratory distress acute respiratory distress syndrome Antigen ARDS attacks bradykinin caused Clinical efficacy clinical status clinical trial ClinicalTrials Comorbidity control group COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Cytokine storm death Diagnosis discharge discharged doses effective Effectiveness Efficacy Efficacy and safety eligible Endothelial cell endothelial cells EudraCT Evidence evidence of expected experimental group global pandemic Healthcare system Healthcare systems hospital Hospitalized Icatibant include infected with SARS-CoV-2 Inflammatory response inhibiting invasive mechanical Invasive mechanical ventilation Mortality multicenter Open-label outcome Patient patients hospitalized Pneumonia Primary outcomes protease pulmonary infiltrates Radiographic randomization Randomized receive receptor receptor antagonist respiratory distress Respiratory distress syndrome RT-PCR Safe Sample size SARS SARS-CoV-2 secondary Secondary outcomes Spain Standard of care Study protocol subcutaneously Symptoms syndrome the SARS-CoV-2 the WHO thought treat Treatment viral infection with COVID-19 working hypothesis [DOI] 10.1186/s13063-022-06219-7 PMC 바로가기 [Article Type] Article
IoT-Enabled Framework for Early Detection and Prediction of COVID-19 Suspects by Leveraging Machine Learning in Cloud클라우드에서 기계 학습을 활용하여 COVID-19 의심의 조기 탐지 및 예측을 위한 IoT 지원 프레임워크Article Published on 2022-04-122022-09-11 Journal: Journal of Healthcare Engineering [Category] 치료기술, [키워드] Accuracy advancement Algorithm Algorithms calculated cloud collected conducted COVID-19 COVID-19 virus Data collection dataset Decision tree detect detection diagnostic early stages effective Efficiency experiment FIVE framework globe health parameter health parameters Healthcare system Healthcare systems Internet Logistic regression machine learning naïve Naïve Bayes outbreak Performance metrics Precision prediction reactive real time recall root searched selected shown Support SVM symptomatic Symptoms the disease virus [DOI] 10.1155/2022/7713939 PMC 바로가기 [Article Type] Article
Machine learning model from a Spanish cohort for prediction of SARS-COV-2 mortality risk and critical patientsSARS-COV-2 사망 위험 및 중환자 예측을 위한 스페인 코호트의 기계 학습 모델Article Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition advance affected age Analysis approach Area AUC can be used Chinese classification clinical Cohort Comorbidities Comorbidity Critical Curve death detect determine develop Diagnosis diagnostic Evolution evolution of patient Factor Healthcare system Healthcare systems help high risk hospital hospitals ICD ICU IMPROVE Inclusion Infection intensive care unit International machine machine learning medical record medical records mortality risk Ninth optimization overcome pandemic Patient patients Population populations predict presenting Prevent Probability problem problems professional resource resources revision robust SARS-COV-2 infection SARS-CoV-2 patients sensitivity severity Sex Spanish Spanish patient stratified the disease the patient transformations Treatment [DOI] 10.1038/s41598-022-09613-y PMC 바로가기 [Article Type] Article
COVID-19 Medical and Pharmacological Management in the European Countries Compared to Italy: An OverviewReview Published on 2022-04-022023-07-08 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), [키워드] COVID-19 deaths rate Healthcare system Paracetamol SARS-CoV-2 epidemiology [DOI] 10.3390/ijerph19074262 PMC 바로가기 [Article Type] Review
Two years after lockdown: reviewing the effects of COVID-19 on health services and support for adolescents living with HIV in South Africa폐쇄 2년 후: 남아프리카 공화국에서 HIV에 감염된 청소년을 위한 의료 서비스 및 지원에 대한 COVID-19의 영향 검토Article Published on 2022-04-012022-09-11 Journal: Journal of the International AIDS Society [Category] 치료제, [키워드] Adolescent adolescents living with HIV affecting Antiretroviral therapy ART ART adherence barriers Care Child consequence COVID-19 Decline Effect greater Health health facilities Health Service Health services healthcare healthcare facility Healthcare system healthcare worker Healthcare workers HIV HIV disease HIV testing identify indirect effect limitation limited support maintain mental health conditions MONITOR National opportunistic infection opportunistic Infections pandemic populations Pregnancy progression Psychological public health reduced reducing Reflecting reproductive resource resource reallocation. resources retention risk Sex Side effects significantly South Africa Structure structures Support Surveillance susceptible therapeutic relationship Transmission Treatment unintended pregnancy with COVID-19 with HIV [DOI] 10.1002/jia2.25904 PMC 바로가기 [Article Type] Article
There is nothing exempt from the peril of mutation – The Omicron spike돌연변이의 위험에서 예외는 없다 - 오미크론 스파이크Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 angiotensin angiotensin-converting enzyme 2 antibody approach approved binding caused Corona Corona virus COVID-19 COVID-19 therapy elevated entry pathway enzyme followed by Health Organization healthcare Healthcare system Interaction kinase inhibitors manuscript mutated Mutation omicron Omicron variant pandemic protease inhibitors RBD Receptor binding domain referred to researcher responsible risk spike Spike protein target the spike protein therapy Transmission Treatment Vaccine variant variant of concern verge Virus Disease VoC WHO World Health Organization [DOI] 10.1016/j.biopha.2022.112756 PMC 바로가기 [Article Type] Review
Clinical and organizational framework of repurposing pediatric intensive care unit to adult critical care in a resource-limited setting: Lessons from the response of an urban general hospital to the COVID-19 pandemicResearch article Published on 2022-04-012022-10-05 Journal: Journal of critical care [Category] 신약개발, 임상, [키워드] addition Admission analyzed ARDS Care children clinical cohort of patient collected COVID-19 COVID-19 incidence COVID-19 pandemic criteria Critical Critical care Critically ill Disaster response equipment First wave Healthcare system healthcare worker hospital ICU in-hospital mortality intensive care Latin America lesson male mechanical ventilation median age outcomes P/F pandemic Patient Patient care pediatric PICU recruitment Result severe COVID-19 the median [DOI] 10.1016/j.jcrc.2021.12.004 [Article Type] Research article
COVID-19 in Elderly, Immunocompromised or Diabetic Patients-From Immune Monitoring to Clinical Management in the Hospital고령자, 면역저하, 당뇨병 환자의 코로나19-면역 모니터링부터 병원 내 임상 관리까지Article Published on 2022-04-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cellular Cellular immune response cellular immune responses clinical Clinical management Cohort cohorts Comorbidities complicate Complication coronavirus correlated Course COVID-19 Ct value cycle threshold detectable develop diabete diabetes Diabetes Mellitus Diabetic diabetic patient elderly elderly patients Factor group Healthcare system hospital Hospitalization Hospitalized humoral Humoral and cellular immune responses humoral immune response humoral immune responses immune response immune responses Immunocompromised Immunocompromised patient Immunocompromised patients increased risk Isolation majority monitoring MOST Nasopharyngeal swab nasopharyngeal swabs Nosocomial infections novel nursing homes pandemic Patient patient cohort patient groups patients patients with diabete positive producing reduced replication-competent virus representing Respiratory illness respond robust SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity severe acute respiratory syndrome Coronavirus symptomatic symptomatic COVID-19 triggered viral culture viral loads virus [DOI] 10.3390/v14040746 PMC 바로가기 [Article Type] Article
SARS COV-2 anti-nucleocapsid and anti-spike antibodies in an emergency department healthcare worker cohort: September 2020 – April 2021응급실 의료 종사자 집단의 SARS COV-2 항뉴클레오캡시드 및 항스파이크 항체: 2020년 9월 - 2021년 4월Article Published on 2022-04-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI age anti-spike antibodies anti-spike antibody antibody antibody level antibody levels Antibody Response Antigen baseline BNT162b2 Breakthrough infection breakthrough infections conducted Course COVID-19 infection decrease described emergency department examined Factor Healthcare system healthcare worker IgG antibodies IgG antibody immunogenicity incidence Infection mRNA mRNA-1273 nucleocapsid nucleocapsid antigen participant positive predictor prospective cohort study reduced SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 spike antigen seronegative participant strained tested the antibody response the SARS-CoV-2 threshold vaccination Vaccine Vaccine immunogenicitiy. were measured [DOI] 10.1016/j.ajem.2022.01.055 PMC 바로가기 [Article Type] Article
Natriuretic peptide level at heart failure diagnosis and risk of hospitalisation and death in England 2004-20182004-2018년 영국에서 심부전 진단 시 나트륨 이뇨 펩티드 수준 및 입원 및 사망 위험Article Published on 2022-04-012022-09-11 Journal: Heart (British Cardiac Society) [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI age all-cause mortality rates association baseline clinical cohort study competing COVID-19 death diagnosed Diagnosis diagnostic England greater guideline Healthcare system Healthcare systems heart heart failure hospitalisation hospitalised IMPROVE IQR mandatory median time men moderate Mortality mortality rate mortality rates Natriuretic NT-proBNP participant Patient peptide Practice pressure Prevent primary care Referral Research risk secondary care survival Treatment while [DOI] 10.1136/heartjnl-2021-319196 PMC 바로가기 [Article Type] Article