Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies3개의 SARS-CoV-2 IgG 항체 분석 및 중화 항체와의 상관관계 평가Article Published on 2021-04-292022-09-12 Journal: The journal of applied laboratory medicine [Category] MERS, SARS, 진단, [키워드] 95% CI Abbott acute phase antibody kinetics Characteristics clinical clinical sensitivity collected Combination comparable Concentration correlation COVID-19 Cutoff demonstrated DiaSorin Euroimmun evaluated healthy individual IgG IgG antibody IgG response individual Infection Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response outbreak Patient positive Quantitative Respiratory illness SARS-CoV-2 SARS-CoV-2 IgG sensitivity sera serologic assay serology specificity specimen tested was determined [DOI] 10.1093/jalm/jfaa188 PMC 바로가기 [Article Type] Article
Comparison of Serological Assays for the Detection of SARS-CoV-2 AntibodiesSARS-CoV-2 항체 검출을 위한 혈청학적 분석법의 비교Comparative Study Published on 2021-04-202022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Antibody detection Antibody Response Antibody test antibody tests biosafety biosafety level Cohort Combination convalescent convalescent plasma coronavirus correlated strongly correlation COVID-19 COVID-19 patient cross-reactivity detect detection detection rate diagnostic discrimination Efficiency ELISA ENhance exposure to healthy individual healthy individuals hospital humans IgG IgG ELISA Infection infection with COVID-19 lentivirus neutralisation test neutralization positive provided pseudotype neutralisation Research SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 pseudotype virus SARS-CoV-2 virus SARS-CoV-2-N Screen sensitivities sensitivity serological serum severe disease spike glycoproteins utility Virus neutralisation VNT was performed [DOI] 10.3390/v13040713 PMC 바로가기 [Article Type] Comparative Study
Cardiovascular Complications of COVID-19: Pharmacotherapy PerspectiveCOVID-19의 심혈관 합병증: 약물 요법의 관점Review Published on 2021-04-012022-09-11 Journal: Cardiovascular Drugs and Therapy [Category] SARS, 치료제, [키워드] 2019 Acute coronary syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered anti-inflammatory agents approved Arrhythmias cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease caused Complication coronary syndrome coronavirus coronavirus disease COVID-19 COVID-19 infection Dexamethasone disease drug Drug–drug interactions Evidence Health Organization healthy individual heart failure Hydroxychloroquine increased risk Interaction medication morbidity Mortality myocarditis Patient patients with COVID-19 pharmacotherapy problem protease inhibitors Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe acute respiratory syndrome Coronavirus therapy Thromboembolism Treatment Venous Thromboembolism World Health Organization [DOI] 10.1007/s10557-020-07037-2 PMC 바로가기 [Article Type] Review
SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacitySalivaDirect: SARS-CoV-2 테스트 용량을 향상시키는 간소화되고 유연한 플랫폼Article Published on 2021-03-122022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 진단, 치료기술, [키워드] authorization center Cohort COVID-19 diagnostic diagnostic test drug Emergency Emergency use authorization ENhance EUA false False-positive family FDA flexible food George Mason global health healthy individual healthy individuals hospital Laboratory Large-scale testing molecular molecular testing Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acid extraction partnership platform Population screening positive qRT-PCR qRT-PCR assay reagent reagents replacing RUBICON Safe Saliva saliva specimen saliva specimens SARS-CoV-2 SARS-CoV-2 testing Scaling specimen supply Supply chain supported Swab swabs tested U.S. Food and Drug Administration university [DOI] 10.1016/j.medj.2020.12.010 PMC 바로가기 [Article Type] Article
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection인간의 일반적인 유전적 변이가 SARS-CoV-2 감염에 대한 시험관 내 감수성에 영향을 미침Article Published on 2021-03-092022-09-11 Journal: Stem Cell Reports [Category] SARS, 변종, [키워드] addition alveolar antibody repertoire Brain Cell clinical complications clinical heterogeneity common Comorbidities contribute COVID-19 COVID-19 pandemic CRISPR disease drugs etiologic agent facilitate furin FURIN rs4702 genetic study Genetic variant Genetic variation healthy individual healthy individuals help Host host genetics host response Human human induced pluripotent stem cell identify Impact in vitro individual individuals Infection influence males Neuron neurons polymorphism predict principle protease SARS-CoV-2 single-nucleotide single-nucleotide polymorphism stem cell UTR Variability viral infection Viral load [DOI] 10.1016/j.stemcr.2021.02.010 PMC 바로가기 [Article Type] Article
Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification바이러스 진입 및 선천 면역의 생식선 유전 변이가 SARS-CoV-2 감염에 대한 감수성에 영향을 줄 수 있음: 위험 계층화를 위한 다유전자 위험 점수를 향하여Review Published on 2021-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 치료기술, [키워드] affected affecting Alter analyzed approach association Autoimmune diseases Bacterial bacterial and viral infections caused Cell Chronic illness clinical consequences clinically complex consequence COVID-19 COVID-19 pandemic detect determinant develop Epidemics Evidence evidence of Factor focus followed by genetic association genetic associations genetic susceptibility Genome genomic genotype-phenotype association studies germline healthcare healthy individual healthy individuals immune influence Innate Innate immunity knowledge Manifestations multitude Novel coronavirus nucleotide older patient older patients polygenic risk score Previous studies previous study Protective provided Recognition risk risk stratification SARS-CoV-2 SARS-COV-2 infection score severe complications Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility loci variants variations Viral viral entry viral infections [DOI] 10.3389/fimmu.2021.653489 PMC 바로가기 [Article Type] Review
Arginase 1 ( Arg1 ) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 ImmunopathyArticle Published on 2021-03-042022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antiviral immune responses antiviral immunity ARG1 arginase AUC Blood caused cDNA characteristic complementary coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated diagnostic diagnostic value DNA dysregulated expressed expression Gene Expression global pandemic healthy individual healthy individuals immune cells immune responses macrophages marker myeloid cells neutrophil outbreak Pathogenesis qPCR Real-time PCR relative expression RNA extraction ROC SARS-CoV-2 SARS-COV-2 infection significantly increased the disease was measured Whole blood [DOI] 10.3390/jcm10051051 PMC 바로가기 [Article Type] Article
Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancerCOVID-19의 새로운 예후 바이오마커로서 순환 미세입자 및 활성화된 혈소판; 암과의 관계Research Article Published on 2021-02-222022-09-10 Journal: PLoS ONE [Category] MERS, 바이오마커, [키워드] accumulated accumulation activated affected AST blood sample Blood samples C-reactive protein Cancer Cancer patients Care Chain Reaction citrate Coagulopathy collected COVID COVID-19 COVID-19 affected patient COVID-19 infection creatinine determine endothelial enrolled healthy controls healthy donor healthy donors healthy individual healthy individuals healthy volunteer hematologic hemoglobin LDH malignant marker Microparticle no significant difference parameters Patient patients Platelet platelet activation Platelets polymerase chain polymerase chain reaction positive COVID-19 prognostic prognostic biomarker Prognostic biomarkers recruited Result reverse transcription reverse transcription polymerase chain reaction RT-PCR severe COVID-19 patient significantly significantly higher significantly lower sodium citrate sodium citrate solution vacutainer tube [DOI] 10.1371/journal.pone.0246806 PMC 바로가기 [Article Type] Research Article
High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiomeResearch Article Published on 2021-02-112022-10-28 Journal: BMC Medicine [Category] Coronavirus, MERS, [키워드] association Bacterial basophil basophils benefit Cardiometabolic risk chronic chronic inflammation correlated covariate COVID-19 diet disease eosinophils false discovery rate Fatty liver Glucose Gut gut microbiome gut microbiome composition healthy individual IL6 Inflammation Inflammatory Inflammatory marker investigated lymphocyte Lymphocyte count lymphocyte counts Lymphocytes marker Mediation analysis Microbiome modulated monocyte multiple testing Neutrophils nutritional intervention processed Result risk RNA Sequencing severe infections significantly supplementary material Variation vegetable intake White blood cell White blood cells [DOI] 10.1186/s12916-021-01913-w PMC 바로가기 [Article Type] Research Article
Rapid Screening of Physiological Changes Associated With COVID-19 Using Soft-Wearables and Structured Activities: A Pilot Study소프트 웨어러블 및 구조화된 활동을 사용하여 COVID-19와 관련된 생리학적 변화의 신속한 스크리닝: 파일럿 연구Article Published on 2021-02-112022-09-12 Journal: IEEE Journal of Translational Engineering in Healt [Category] MERS, 진단, [키워드] activities activity approach AUC change Classifier clinical clinical impact Cohort controlling cough COVID-19 COVID-19 pandemic cross detect diagnostics Digital health elicited feature Frequency healthy individual healthy individuals heart rate individual infected individuals Infection limitation Non-invasive participant performed physical activity physiological physiological response physiological responses pilot study positive Rapid respiration rate Screening sequence soft electronics solution Spread suprasternal Suprasternal notch Symptom tested the healthy Variability wearable sensors with COVID-19 [DOI] 10.1109/JTEHM.2021.3058841 PMC 바로가기 [Article Type] Article