Skin Manifestation of SARS-CoV-2: The Italian ExperienceArticle Published on 2021-04-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] case sery China coronavirus 2 Coronavirus disease-19 Course COVID-19 experience foci global pandemic histological histopathological Italian Italy manifestation molecular New coronavirus nine Patient patients PCR polymerase chain provided reported respiratory SARS-CoV-2 skin specimens supported the disease WHO World Health Organization Wuhan [DOI] 10.3390/jcm10081566 PMC 바로가기 [Article Type] Article
A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge ModelArticle Published on 2021-04-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal animal model antibody approach cellular fraction challenge clinical evaluation COVID-19 COVID-19 pandemic demonstration disease Diseases effective Efficacy flow cytometric hamster histopathological immune responses immune stimulation Immunological response Inactivated vaccine Inactivated virus vaccine Infection live SARS-CoV-2 many cases Model neutralizing antibody novel photochemical Prevent produced promote RBD Riboflavin SARS-CoV-2 SARS-CoV-2 virus single cell sequencing Spike protein spread of COVID-19 Th1 tissue utility UV light vaccination Vaccine vaccine candidate vaccine for COVID-19 vaccine production viral shedding virion [DOI] 10.3390/vaccines9040340 PMC 바로가기 [Article Type] Article
Ivermectin reduces in vivo coronavirus infection in a mouse experimental modelArticle Published on 2021-03-302022-10-04 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] alanine aminotransferase Aspartate aminotransferase control group coronavirus diseases Coronavirus infection demonstrated disease Diseases Effectiveness euthanized general health status Health status hepatocellular histopathological in vivo infection levels infiltration Inflammatory Ivermectin liver Liver damage MHV MHV-A59 mice mouse hepatitis virus Necrosis PBS reduce RNA coronavirus SARS-CoV-2 serum transaminase significant difference significantly lower Signs and symptoms single dose therapy tissue treated Treatment viral infection Viral load were infected [DOI] 10.1038/s41598-021-86679-0 PMC 바로가기 [Article Type] Article
Correlation of autopsy pathological findings and imaging features from 9 fatal cases of COVID-19 pneumoniaObservational Study Published on 2021-03-262022-10-04 Journal: Medicine [Category] SARS, 임상, [키워드] acute fibrinous alveolar analyzed assessment Autopsies Autopsy bacterial co-infection Chest CT consolidation correlated COVID-19 Critically ill DAD damaged Diffuse alveolar damage early stage ENhance facilitate feature fibrosis ground-glass opacity histopathological Histopathology hyaline membranes implication Infection inflammatory cell infiltration interlobular interstitial inflammation interstitial thickening lung male mechanism multicenter occur pathological finding pathological findings Patient Pneumonia Postmortem predominant Prognosis proliferation Pulmonary edema pulmonary injury Pulmonary pathology Radiographic radiological Radiological Diagnosis radiological feature Research severity Structure subpleural supported tissue Treatment [DOI] 10.1097/MD.0000000000025232 PMC 바로가기 [Article Type] Observational Study
Kidney transplant dysfunction in a patient with COVID − 19 infection: role of concurrent Sars-Cov 2 nephropathy, chronic rejection and vitamin C-mediated hyperoxalosis: case reportCase Report Published on 2021-03-152022-10-28 Journal: BMC Nephrology [Category] COVID-19, [키워드] Acute kidney injury aetiology Allograft allograft dysfunction antibody biopsy booster Case report Combination complex COVID COVID-19 disease COVID-19 infection COVID-19 nephropathy demonstrated diarrhoea disease dysfunction Endothelium Fever glomerular Haemodialysis High dose highlight histopathological immune Inclusion India Infection Injury kidney kidney transplant kidney transplant recipient Manifestations nasal swab nephropathy oxalate Oxalate nephropathy Particle pathology Patient positive rejection renal SARS CoV-2 tested Tubulo-reticular inclusions Vitamin [DOI] 10.1186/s12882-021-02298-x PMC 바로가기 [Article Type] Case Report
Emergency Lung Transplantation after COVID-19: Immunopathological Insights on Two Affected PatientsCOVID-19 이후 긴급 폐 이식: 영향을 받은 두 환자에 대한 면역병리학적 통찰력Case Reports Published on 2021-03-102022-09-12 Journal: Cells [Category] 진단, [키워드] activating ARDS Bronchoalveolar lavage fluid chemokines chemotactic collected components condition COVID-19 COVID-19 patient Culture cytokine Cytokine analysis Diffuse alveolar damage disease Emergency expression profiling extensive lung damage Factor feature histopathological Humoral immunity iatrogenic IL-6 immune activation immune profiling immunology immunopathological Immunosuppression Inflammasome insight interstitial pneumonia Italian lung lung transplantation Lungs mimicking molecular mononuclear cell overexpression pathogen pathological PBMCs Peripheral blood proinflammatory proliferative receptor receptors SARS-CoV-2 SARS-CoV-2-stimulated PBMC specimen supernatants Support sustained tissue damage TNF-α usual interstitial pneumonia was performed were measured [DOI] 10.3390/cells10030611 PMC 바로가기 [Article Type] Case Reports
A Pictorial Review of the Role of Imaging in the Detection, Management, Histopathological Correlations, and Complications of COVID-19 PneumoniaReview Published on 2021-03-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] ARDS Chest computed tomography Chest CT chest CT protocols chest CT severity scores chest X-ray chest X-ray protocols chest X-ray scoring system Complication complications coronavirus correlations COVID-19 COVID-19 complications COVID-19 patient COVID-19 pneumonia imaging guidelines CXR detection Diagnosis histopathological histopathological correlations imaging indications lung Lung ultrasound lung ultrasound protocols lung ultrasound scoring system management outcomes Pneumonia Predictive prognostic review role the disease [DOI] 10.3390/diagnostics11030437 PMC 바로가기 [Article Type] Review
Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaquesArticle Published on 2021-03-022022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] Administered affected alveolar epithelium Bronchoalveolar lavage fluid Candidates clearance clinical development clinical trial COVID-19 pandemic days post-infection develop effective vaccine Efficacy exhibited FIVE four group groups Health histopathological IgG immunized immunogenicity immunohistochemistry inactivated Inactivated Vaccines India interstitial pneumonia lung tissue macaque Macrophage nasal swab Neutralizing antibody titer no evidence of overcome pandemic phase Placebo Pneumonia Preclinical research Protective public health rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine second dose the placebo group the vaccine three group throat swab Vaccine vaccine candidate Viral antigen viral infection [DOI] 10.1038/s41467-021-21639-w PMC 바로가기 [Article Type] Article
Potential Mechanisms of Cardiac Injury and Common Pathways of Inflammation in Patients With COVID-19COVID-19 환자의 심장 손상 및 일반적인 염증 경로의 잠재적 기전Review Published on 2021-03-012022-09-11 Journal: Critical pathways in cardiology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute infectious disease Acute myocarditis acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Apoptosis association autopsy studies binding affinity biologic Biomarker Biomarkers C-reactive protein cardiac cardiac injury cardiovascular complication cardiovascular complications Clinical studies clinical study common controlled clinical studies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine secretion demonstrated despair disease pathogenesis effort Epidemic Genetic genetic recombination High-sensitivity C-reactive protein higher risk histopathological hypoxia in-hospital mortality Inflammation Injury lack lethal disease linear correlation management mechanism morbidity and mortality Myocardial myocarditis other coronaviruses outbreak Outbreaks pandemic Pathogenesis Patient patients hospitalized plasma poor prognosis positive linear correlation Potential potential mechanism Protein Randomized Receptor binding Recombination remains uncertain reported Research risk factor Risk factors significantly spike Spike protein Strong systemic inflammation the disease therapeutic tissue damage Treatment troponin T virus virus spike protein with COVID-19 [DOI] 10.1097/HPC.0000000000000227 PMC 바로가기 [Article Type] Review
Case Report: Post-mortem Histopathological and Molecular Analyses of the Very First Documented COVID-19-Related Death in EuropeMedicine Published on 2021-02-192022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] appear Autopsy caused coronavirus 2 coronavirus disease COVID-19 COVID-19 infection COVID-19-related death death Europe Europe (central) faster France histopathological molecular analyses Pneumonia Post-mortem Registered reported respiratory retrospective detection SARS-CoV-2 took place vitreous vitreous humor [DOI] 10.3389/fmed.2021.612758 PMC 바로가기 [Article Type] Medicine