A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 헵타드 반복 2 도메인을 표적으로 하는 5개 나선 기반 SARS-CoV-2 융합 억제제Article Published on 2022-03-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] 5-Helix acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 cell-cell fusion concern conserved conserved region Coronavirus-2 COVID-19 vaccines Delta delta variant domain Efficacy fusion fusion inhibitor helix heptad repeat heptad repeat 1 heptad repeat 2 homologous Infection inhibited Lambda nCoV omicron Omicron variants pandemic Prevent Prophylactic Protective Protein pseudotyped SARS-CoV-2 Recombinant protein Repeat S-mediated cell-cell fusion S2 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 six-helix bundle targeting therapeutic treat variant variant of concern variants variants of concern variants of interest VoC VOCs wild-type [DOI] 10.3390/v14030597 PMC 바로가기 [Article Type] Article
Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in ItalyArticle Published on 2022-03-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] analysed Analysis chose Clinical characteristics collected country COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional dose effective enrolled female females first dose Generalized linear model Heterologous homologous homologous or heterologous individual individuals Italian Italy majority Ministry of Health pandemic Population public health measure qualitative data recommendation regimen regimens Safe Safety second dose second vaccination Side-effect socio-demographic thematic analysis vaccination vaccine doses Vaccine uptake Vaccines Viral vector vaccine younger people [DOI] 10.3390/ijerph19052944 PMC 바로가기 [Article Type] Article
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination동종 및 이종 CoronaVac 또는 BNT162b2 백신 접종 후 SARS-CoV-2 Omicron 변이체 BA.1에 대한 중화 항체Article Published on 2022-03-012022-09-11 Journal: Nature Medicine [Category] SARS, 변종, 진단, [키워드] antibody Antibody titer BNT162b2 booster booster dose circulating convalescent CoronaVac country dominant dose Effectiveness elicited geometric mean geometric mean titer GMT Heterologous homologous individual infected individual Infection Live virus Messenger RNA Neutralizing activity of BNT162b2 omicron Omicron variant plaque plaque reduction neutralization PRNT reduced reductions reductions in SARS-CoV-2 SARS-CoV-2 virus serum serum antibody Spread the SARS-CoV-2 threshold to define vaccinated individual vaccinated individuals vaccination Vaccine variant virus wild-type WT virus [DOI] 10.1038/s41591-022-01704-7 PMC 바로가기 [Article Type] Article
CD4 + T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronavirusesClinical Trial Published on 2022-03-012022-10-04 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, [키워드] Adaptive immunity assays bat coronavirus bat coronaviruses BNT162b2 CD4 common cold Coronaviruses conserved coronavirus Coronaviruses COVID-19 COVID-19 vaccines demonstrated elicit Endemic epitope homologous Hypothesis induce majority MERS-CoV Moderna mRNA vaccine mRNA-1273 Outbreaks Pandemics participant peptide Pfizer-BioNTech recent recipient recognize Responder SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Sequencing shown Support T cell T cell receptor T cell response vaccinated individual Vaccine zoonotic [DOI] 10.1172/JCI156083 PMC 바로가기 [Article Type] Clinical Trial
Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19경증 또는 중증 COVID-19 환자와 COVID-19 백신 1차 및 2차 접종 후 항체 반응 비교Comparative Study Published on 2022-03-012022-09-11 Journal: The Korean journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Adult patients analyzed antibody formation Antibody Response Antibody responses blood sample Blood samples BNT162b2 BNT162b2 vaccine ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine collected comparable convalescent patient Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccination COVID-19 vaccine dose enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay first dose healthcare healthcare worker homologous immune response immune responses Immunity Immunoglobulin Immunoglobulin G Infection intervals Mild mRNA vaccination Patient patients SARS-CoV-2 SARS-CoV-2 variant second dose severe COVID-19 single dose Spike protein the antibody response vaccine platform Vaccines [DOI] 10.3904/kjim.2021.409 PMC 바로가기 [Article Type] Comparative Study
Immunogenicity and reactogenicity of homologous mRNA-based and vector-based SARS-CoV-2 vaccine regimens in patients receiving maintenance dialysis유지 투석을 받는 환자에서 상동 mRNA 기반 및 벡터 기반 SARS-CoV-2 백신 요법의 면역원성과 반응성Article Published on 2022-03-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Anti-spike IgG antibody assays benefit cellular Cellular immune response cellular immunity CMIA Complete conducted COVID-19 dialysis dose ELISPOT Hemodialysis homologous humoral immune response Humoral immunity immune immune response immunization immunoassay immunogenicity immunoglobulins interferon-γ Microparticle morbidity and mortality mRNA-based Patient Peritoneal dialysis predict reactogenicity receiving regimen SARS-CoV-2 vaccine seroconversion rate single dose single-center study T cell T cells the patient vaccine injection while [DOI] 10.1016/j.clim.2022.108961 PMC 바로가기 [Article Type] Article
Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients비활성화된 SARS-CoV-2 백신의 추가 접종 전 운동 시합이 면역 저하 환자의 면역원성에 미치는 영향Randomized Controlled Trial Published on 2022-03-012022-09-12 Journal: Journal of applied physiology (Bethesda, Md. : 198 [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] anti-SARS-CoV-2 assigned booster booster dose comparable consecutive patient control group COVID-19 COVID-19 vaccine Effect ENhance exercise exhibited Frequency geometric mean titer GMT group homologous IgG immunized Immunocompromised patient immunogenicity Immunosuppression in both groups inactivated Inactivated vaccine intervention group NAb activity Neutralizing antibodies neutralizing antibody occurred Patient performed physical physical activity positive randomized controlled study remained resistance exercise resistance exercise. S1/S2 SARS-CoV-2 SARS-CoV-2 vaccine selected serology Sinovac-CoronaVac spondyloarthritis tested the vaccine vaccination [DOI] 10.1152/japplphysiol.00015.2022 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Comparability of Anti-Spike SARS-CoV-2 Antibody Tests is Time-Dependent: a Prospective Observational StudyAnti-Spike SARS-CoV-2 항체 검사의 비교 가능성은 시간에 따라 달라집니다: 전향적 관찰 연구Observational Study Published on 2022-02-232022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Abbott agreement antibody Antibody assays antibody levels Antibody test antibody tests AZD1222 binding antibody Blood blood collection booster changed clinical setting clinical settings clinician comparability correlation dependent on evaluated first dose greater homologous Initially International international standard Neutralization assay observational study participant Prospective prospective observational study provided quantified Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody test SARS-CoV-2 antibody tests second dose serology significantly Standardization Test the timing time-dependency vaccination Withdrawal [DOI] 10.1128/spectrum.01402-21 PMC 바로가기 [Article Type] Observational Study
Revival of the heterologous prime‐boost technique in COVID ‐19: An outlook from the history of outbreaksVaccines Published on 2022-02-232022-11-01 Journal: Health Science Reports [Category] COVID-19, [키워드] addition Appendix approach article Canada carried clinical study ClinicalTrials competency Controlled Controlled trial country COVID COVID‐19 COVID‐19 vaccines Critical database Ebola Ebola virus disease English language Evolution expected Germany globe help hepatitis B Heterologous heterologous prime‐boost technique HIV homologous immune response immunization include Influenza virus majority malaria material Mix and Match approach omicron outbreak Outbreaks positive Primary outcomes public health reactogenicity recipients regimen reported Result retrieved risk SARS‐CoV‐2 Spread Tuberculosis turn United Kingdom vaccinate vaccination Vaccine variant WHO [DOI] 10.1002/hsr2.531 PMC 바로가기 [Article Type] Vaccines
Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study3차 접종 동종 BBIBP-CorV 부스팅 백신의 안전성 및 면역원성: 전향적 공개 연구의 중간 결과Original Article Published on 2022-02-232022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Administered Adults adverse event anti-RBD antibody baseline baseline level baseline levels BBIBP-CorV booster booster vaccination booster vaccination shot cell-mediated immune circulating concern conducted control group COVID-19 dose evaluated examined female GMT healthy homologous humoral IFN-γ IgG Immunity immunogenic immunogenicity Neutralizing titer neutralizing titers Open-label participant PBMC PBMCs peptide prototype reduced reported Safe Safety SARS-CoV-2 SARS-CoV-2 inactivated vaccines SFU significant increase significantly higher significantly increased sVNT vaccination variants VoC VOCs [DOI] 10.1080/22221751.2022.2025746 PMC 바로가기 [Article Type] Original Article