Implications – Page 12 – Communicable Diseases Research

Machine Learning on the COVID-19 Pandemic, Human Mobility and Air Quality: A Review

Computers and Information Processing

Published on 2021-05-112022-10-30
Journal: Ieee Access [Category] COVID-19,

Peering inside a cough or sneeze to explain enhanced airborne transmission under dry weather

Article

Published on 2021-05-102022-10-29
Journal: Scientific Reports [Category] Coronavirus, SARS,

[키워드] ambient Applied physics condition conditions Contagion cough droplet Evolution experiment explain Fluid dynamics Implications nuclei observé occur offer Peering predict reduced resulting risk sneeze social distancing Spread Transmission transported Variation variety while
[DOI] 10.1038/s41598-021-89078-7 PMC 바로가기 [Article Type] Article

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications

SARS-CoV-2 막 단백질에서 우려되는 새로운 변종: 잠재적인 병리학적 및 치료적 의미를 지닌 고도로 보존된 표적

Research Article

Published on 2021-05-092022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종,

[키워드] accounted age B.1 lineage B.1.1.7 B.1.429 clade conjunction conserved COVID-19 defined dominant lineage e genes effort ENCODE Europe Frequency functions genomic Genomic surveillance Glucose host cell implicated implication Implications incidence increase in initial isolate isolates Lineage lineages M gene M:I82T mutation membrane membrane protein Mutation mutations pangolin pathogenic Patient patient age Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes structural protein sulphate Surveillance the SARS-CoV-2 therapeutic transmembrane Transport USA variant of concern variants of concern Viral Viral protein viral replication while
[DOI] 10.1080/22221751.2021.1922097 PMC 바로가기 [Article Type] Research Article

ATTR amyloidosis during the COVID-19 pandemic: insights from a global medical roundtable

Position Statement

Published on 2021-05-062022-10-29
Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome age amyloid amyloidosis ATTR Cardiomyopathy Care cause chronic disease clinical manifestations clinically Complication coronavirus coronavirus disease correlation COVID-19 develop Diagnosis dysfunction evaluated fibril Gastrointestinal symptom Health heterogeneous higher risk immune Implications Infection management morbidity morbidity and mortality Multiorgan organ organ dysfunction organ system outcome pandemic Patient physician preexisting comorbidities progressive disease raised rare disease renal renal dysfunction Research Respiratory system resulting risk SARS-CoV-2 severity of COVID-19 Spread susceptibility tissues Treatment unique while with COVID-19
[DOI] 10.1186/s13023-021-01834-0 PMC 바로가기 [Article Type] Position Statement

COVID-19, Social Isolation, and Mental Health Among Older Adults: A Digital Catch-22

Viewpoint

Published on 2021-05-062022-10-30
Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS,

Biological responses to COVID-19: Insights from physiological and blood biomarker profiles

COVID-19에 대한 생물학적 반응: 생리학적 및 혈액 바이오마커 프로필에서 얻은 통찰력

Article

Published on 2021-05-012022-08-31
Journal: Current research in translational medicine [Category] MERS, SARS, 바이오마커,

[키워드] accompanied Admission adverse outcomes Analysis baseline best Biological biological response biological responses Biomarker Biomarkers Blood C-reactive protein Characteristics class Classes collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 Course COVID-19 CRP death declined elevated empirical evidence Evidence except for exhibited FIVE heterogeneous highest hospitalised Hyperinflammatory Hyperinflammatory response Implications Inflammation Inflammatory Inflammatory response insight intensive care kidney Kidney injury laboratory-confirmed Laboratory-confirmed COVID-19 Latent latent profile analysis lowest male measure median age mortality rate mortality risk neutrophil neutrophil counts older patients pathophysiology Patient performed physiological Platelet Platelet count profile provide provided renal renal failure response retrospective cohort study rising SARS-CoV-2 severe COVID-19 Spectrum targeted therapy therapeutic understanding unique was performed white cell
[DOI] 10.1016/j.retram.2021.103276 PMC 바로가기 [Article Type] Article

Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm

Review

Published on 2021-04-292022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Activation acute respiratory distress acute respiratory syndrome alveolar cell Anti-inflammatory anti-inflammatory drug antiviral drug B cell candidate cascade caused cells characterized Chronic diseases Complication complications coronavirus Coronavirus disease 2019 counter COVID-19 COVID-19-related complications cytokine Cytokine storm drug drugs dysregulated effective elevated event function Genomics hypercytokinemia Hyperinflammatory IL-1 IL-6 Immune cell Immunity immunological pathways immunomodulatory drug immunomodulatory drugs immunopathology Implications incidence Inflammatory Inflammatory cytokines Inflammatory marker inflammatory monocyte Jak JAK/STAT signaling lung alveolar Macrophage macrophages measure mechanisms molecular mortality rate multiple organ failure pandemic pathway Pathways Pneumonia pro-inflammatory cytokine progression recruit reported review role SARS-CoV-2 secretion severely ill patient severity storm suppressed survival rate syndrome the cytokine storm the disease therapeutic drug Therapies TNF-α Trial viral infection with COVID-19
[DOI] 10.3390/vaccines9050436 PMC 바로가기 [Article Type] Review

Intercellular viral spread and intracellular transposition of Drosophila gypsy

초파리 집시의 세포간 바이러스 전파 및 세포내 전위

Research Article

Published on 2021-04-222022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence acquisition age aging ancestor animals arthropods assembly Author biological processe biological processes Cancer Cell chromosome chromosomes Combination develop disease Drosophila dysfunction element elements envelope gene Evidence exhibit exogenous retrovirus exogenous retroviruses expressed expression feature functional Genome genomes genomic germ line glial cell glial cells host genome implicated Implications incompatible increasingly infectious intercellular Like Long Long Terminal Repeat murine myriad neurodegeneration Neuron neurons occur organism plant plants Protein question raise related diseases Repeat replicate Replication retrotransposon retrotransposons retroviral retrovirus retroviruses similarity somatic cell somatic cells terminal the cell thought tissue transitioned Transmission Viral viral envelope protein viral spread Viral transmission viruses
[DOI] 10.1371/journal.pgen.1009535 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 within-host diversity and transmission

SARS-CoV-2 호스트 내 다양성 및 전송

Research Article

Published on 2021-04-162022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody treatment association average bottleneck bottlenecks carried characterized clinical sample clinical samples Coinfection concerning Consensus consensus sequence Contact Contamination coronavirus cycle threshold dataset de novo mutation de novo mutations described detectable determinant Diagram dissemination Diversity dN/dS early infection Effect eight escape mutation events Evidence explained Extensive First wave fixation fixed functional genetic diversity Genetic variation Genome sequencing genomic help helping high viral load hospital Host Households identify Implications indicate individual individuals Infection initiated interquartile iSNV iSNVs isolate Limited genetic diversity MAF MAFs mapped minor allele frequency mixed infection MONITOR MOST Mutation Narrow nonsynonymous nucleotide observation OC43 offer pandemic pandemic virus Patient pattern persistence Phylogenetic tree phylogenetically Phylogeny Population reached replicate researcher respiratory responsible resulting RNA sample RNA samples robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants Science sequenced Sequencing severe acute respiratory syndrome Coronavirus shown Single nucleotide variant spike spike gene Spike protein spike variants Spread subset synonymous the mean the Spike the spike protein therapeutic threshold Transmissibility Transmission transmission cluster transmission clusters transmitted United Kingdom unlikely Vaccine variant variant frequencies variant frequency variants variants of concern veSEQ Viral viral entry viral evolution viral infectivity Viral load viral loads virus viruses Waves were excluded whole genome
[DOI] 10.1126/science.abg0821 PMC 바로가기 [Article Type] Research Article

Rescue of Infectious Sindbis Virus by Yeast Spheroplast-Mammalian Cell Fusion

Article

Published on 2021-04-012022-10-28
Journal: Viruses [Category] Coronavirus, MERS, SARS,