Physical Activity Behavior Before, During, and After COVID-19 Restrictions: Longitudinal Smartphone-Tracking Study of Adults in the United KingdomOriginal Paper Published on 2021-02-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, [키워드] activity age Apps baseline Behavior change changes in COVID-19 COVID-19 pandemic decile demographics Deprivation estimating equation examined fairly active female fitness trackers Friedman Gender Government groups implementation inactive index less Level lockdown longitudinal measure median mHealth mobile apps Multiple nonparametric test objective pandemic pattern physical activity reduce reduction in reported Result Significant significant changes in Smartphone social contact social distancing Sociodemographic characteristics Spread the median tracking United Kingdom viral spread were used [DOI] 10.2196/23701 PMC 바로가기 [Article Type] Original Paper
High-resolution mining of the SARS-CoV-2 main protease conformational space: supercomputer-driven unsupervised adaptive sampling †Chemistry Published on 2021-02-022022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] adaptive appear approach C-terminal Clustering analysis conformational Critical distal Drug discovery exhibit Focusing GPU High-resolution highlight histidine inactive less M pro marker mimicking modulating molecular molecular interaction monomer observé performed physiological plasticity producing protease reducing residue residues Result selective shown stability statistical the SARS-CoV-2 trajectory Volume was performed water molecule [DOI] 10.1039/d1sc00145k PMC 바로가기 [Article Type] Chemistry
COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseasesCOVID-19와 후각 기능 장애: 신경 퇴행성 질환에 대한 가능한 연관 접근법Review Published on 2021-02-012022-09-11 Journal: Journal of cellular physiology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect agent Anosmia approach associative Brain cellular Central nervous system chronic infection CNS conditions coronavirus COVID-19 disease dysfunction Fever globe Health care health care workers Host Hypogeusia Hyposmia inactive infect lead life-threatening mechanism microglia nasal epithelium neurodegenerative neurodegenerative disorders Neuroinflammation Neuron Novel coronavirus olfactory olfactory bulb olfactory bulb dysfunction. phenotype respiratory SARS-CoV-2 SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus Shortness of breath sore throat suggested symptoms of COVID-19 the SARS-CoV-2 tissue tissues virus [DOI] 10.1002/jcp.29937 PMC 바로가기 [Article Type] Review
An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responsesReview Published on 2021-01-102022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, [키워드] Abstract Activation acute respiratory illness Anti-viral approaches autoimmune reactions beta-coronavirus bi-allelic blood circulation coronavirus COVID-19 COVID19 disease epidemiological expression Fatality rate feature female females Frequency Genes Host immune response IFN immune Immune cell immune protection immune response immune responses immune system Immunotherapy inactive Infection infection rate information involved less male MERS MERS-CoV Middle East pathogen Regulatory respiratory respiratory infection responsible robust SARS SARS-CoV-1 SARS-CoV-2 similarity susceptibility susceptible the antibody TLR7 Treatment Vaccine development Variation viral infections Viral load X-linked β-CoVs [DOI] 10.1016/j.intimp.2021.107365 PMC 바로가기 [Article Type] Review
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive SpikeReport Published on 2020-12-182022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affinity airway epithelia angiotensin-converting enzyme 2 Anti-spike antibody Bacteria bind binding cells coronavirus cryo-EM disrupt group host cell host cell receptor inaccessible inactive Interaction intravenously mammalian cell maturation Microscopy multivalent nanobodies nanobody neutralization neutralize potent produced Protein Receptor binding domain SARS-CoV-2 SARS-COV-2 infection Science screened selected spike stability synthetic nanobody the spike protein therapeutic Treatment trivalent virus yeast [DOI] 10.1126/science.abe3255 PMC 바로가기 [Article Type] Report
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2Report Published on 2020-12-182022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affinity Anti-spike antibody Bacteria cells complex Concentration coronavirus COVID-19 pandemic group half-maximal inhibitory concentration identify immunization inactive indicated inhibit intravenously mammalian cell mechanisms microbe multivalent nanobodies nanobody neutralization neutralization potency neutralize Neutralizing nonoverlapping epitope potent Prevent produced proteomics RBD Receptor binding domain SARS-CoV-2 Science screened selected Spike protein stability synthetic nanobody the RBD the spike protein therapeutic viral infection yeast [DOI] 10.1126/science.abe4747 PMC 바로가기 [Article Type] Report
Exploring Perceived Stress among Students in Turkey during the COVID-19 PandemicArticle Published on 2020-12-022022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] activity Anxiety conducted COVID COVID-19 COVID-19 pandemic cross-sectional Depression Diagnostic Criteria female GAD GAD-7 Gender Generalized Generalized Anxiety Disorder (GAD) scale Hierarchical high risk Impact inactive life Linear regression model mental health mental health issue mental health problem Mild pandemic Perceived Perceived stress Perceived Stress Scale Perceived Stress Scale (PSS) Perception Physical inactivity physically predicted predictor Prevalence PSS-10 reported researcher Satisfaction Satisfaction with Life Scale (SWLS) scale shown significantly Sociodemographic stress levels student Turkey [DOI] 10.3390/ijerph17238961 PMC 바로가기 [Article Type] Article
Differential impact of BTK active site inhibitors on the conformational state of full-length BTKResearch Article Published on 2020-11-232022-10-31 Journal: eLife [Category] Coronavirus, SARS, [키워드] activated Affect allergy Allostery antibodies approved Asthma B cell B-cell B-cells bind binding Blood bruton tyrosine kinase BTK BTK inhibitor BTK inhibitors Cancer Cancer cells cancers catalytic activity change Chemotherapy conformational consequence COVID-19 Diseases disorder disrupt disrupting domain domains drug drug resistance drugs Effect effective enzyme examined FIVE full-length full-length protein Future help hydrogen/deuterium exchange mass spectrometry Ibrutinib inactive increase inhibitor inhibitors Interaction Joseph Kinase inhibitor leukemia lymphoma lymphomas maintain mechanism modify Mutation None not affect nuclear magnetic resonance other compound other disease phosphate Previous effort Protein Proteins Region regions Regulatory regulatory domain regulatory region Research responsible shifting treat treated treating COVID-19 Treatment treatment strategy tyrosine understanding while White blood cell [DOI] 10.7554/eLife.60470 PMC 바로가기 [Article Type] Research Article
Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of “Up” versus “Down” protomer statesResearch Article Published on 2020-11-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE-2 receptor acting Amino acid Analysis backbone atom binding characteristic conducted conserved COVID-19 Critical cross demonstrated determine disrupting distal domain dominant example experimental structure human epithelial cells inactive include independent Interaction interactions intrachain involved Molecular dynamics simulation Mutation NTD pandemic performed Point mutation prefusion Protein provided proximal RBD Receptor binding domain reduced reported residue responsible S1 domain SARS-CoV-2 sequence spike Spike protein stability Static the RBD the SARS-CoV-2 trimeric turn Van der Waals Variation virion virus [DOI] 10.1371/journal.pone.0241168 PMC 바로가기 [Article Type] Research Article
Loneliness during a strict lockdown: Trajectories and predictors during the COVID-19 pandemic in 38,217 United Kingdom adultsArticle Published on 2020-11-012022-10-29 Journal: Social science & medicine (1982) [Category] Coronavirus, SARS, [키워드] age analysed Analysis baseline changed Clustering collecting data coronavirus COVID COVID-19 COVID-19 pandemic decrease effort Factor Gender geographical location greater growth trajectories growth trajectory Health highest identify inactive lockdown loneliness longitudinal lowest measure mental health mental health condition objective pandemic Perceived predictor predictors profile proportion Protective public health rationale Result risk factor Seven slight increase Social factor Support Trajectories trajectory two groups UCL United Kingdom was used women [DOI] 10.1016/j.socscimed.2020.113521 PMC 바로가기 [Article Type] Article