Acceptability of Telegenetics for Families with Genetic Eye Diseases유전성 안질환이 있는 가족을 위한 원격 유전학의 수용 가능성Article Published on 2021-02-152022-09-10 Journal: Genes [Category] MERS, 유전자 메커니즘, [키워드] acceptability Care carried children clinical clinics Contact COVID-19 pandemic disease disorder Disruption eye Families family foundation Genetic genetic counselling genetic eye disease genetics healthcare providers Indicator information Moorfield NHS ocular ophthalmology opinion participant participated Patient Patient satisfaction rare disease remote consultations response rate Satisfaction service delivery telegenetics Telemedicine telephone telephone consultation Travel Trust [DOI] 10.3390/genes12020276 PMC 바로가기 [Article Type] Article
Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand태국 코로나19 환자에서 SARS-CoV-2에 대한 중화항체 조기 발견Research Article Published on 2021-02-122022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval biosafety can be used clinically collected COVID-19 patient COVID-19 symptoms detect determine Diagnosis diagnosis of SARS-CoV-2 Early detection IgG antibody IgM/ IgG antibody Indicator Infection interquartile range IQR isotype median Mild mild symptoms moderate NAb NAbs Negative predictive value neutralization activity Neutralizing antibodies neutralizing antibody offer Patient patients PCR-confirmed PCR-confirmed COVID-19 patients positive Predictive value protective immune response protective immunity real-time RT-PCR Receptor binding Receptor binding domain Result robust SARS-CoV-2 SARS-COV-2 infection sensitivity serological test severity of COVID-19 significantly higher specificity specimen surrogate viral neutralization assay sVNT Symptom symptom onset the patient Viral viral infections viral neutralization weakly positive [DOI] 10.1371/journal.pone.0246864 PMC 바로가기 [Article Type] Research Article
Letter to the Editor: Additional Factors to Consider When Studying Liver Injury Indicators and Mortality in COVID-19 Patients편집자에게 보내는 편지: COVID-19 환자의 간 손상 지표 및 사망률을 연구할 때 고려해야 할 추가 요소Comment Published on 2021-02-012022-09-11 Journal: Hepatology (Baltimore, Md.) [Category] MERS, 바이오마커, [키워드] COVID-19 Factor Indicator [DOI] 10.1002/hep.31445 PMC 바로가기 [Article Type] Comment
Diagnostic utility of C-reactive protein to albumin ratio as an early warning sign in hospitalized severe COVID-19 patients입원한 중증 COVID-19 환자의 조기 경고 신호로서 C 반응성 단백질 대 알부민 비율의 진단 유용성Article Published on 2021-02-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 바이오마커, 진단, [키워드] Admission age albumin Analysis aspartate Aspartate aminotransferase assigned AST C-reactive protein C-reactive protein to albumin ratio calculation CAR characteristic Clinical symptoms Comorbidities COVID-19 COVID-19 severity CRP cut-off value demographic data determine determined by diagnostic differentiation Diseases evaluated ferritin group hospital Hospital stay Hospitalized independent risk factor independent risk factors Indicator Laboratory laboratory data Laboratory test Logistic regression analysis lymphocyte Lymphocyte count marker median Mortality multivariate logistic regression multivariate logistic regression analysis neutrophil neutrophil count non-severe patient non-severe patients Patient patients hospitalized Predictive Prognosis prothrombin Prothrombin time receiver operating characteristic risk factor ROC ROC Curve SARS-CoV-2 sensitivity severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity severity of COVID-19 specificity the patient two group two groups utility was used [DOI] 10.1016/j.intimp.2020.107285 PMC 바로가기 [Article Type] Article
Indicator Regularized Non-Negative Matrix Factorization Method-Based Drug Repurposing for COVID-19COVID-19에 대한 지표 정규화된 비음성 매트릭스 분해 방법 기반 약물 용도 변경Immunology Published on 2021-01-292022-08-31 Journal: Frontiers in Immunology [Category] SARS, 신약개발, 치료제, [키워드] Algorithm analyzed approved drugs Area associations AUC biological networks characteristic COVID-19 COVID-19 infection Curve dataset de novo drug Drug discovery Drug repurposing drugs Efficacy Indicator Infectious disease Infectious diseases introduced matrix non-negative matrix factorization Novel coronavirus prevalent receiver operating characteristic reduce repurposing semi-supervised learning significantly suggested tested therapeutic drug Vaccine viruses [DOI] 10.3389/fimmu.2020.603615 PMC 바로가기 [Article Type] Immunology
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys단일 세포 RNA 시퀀싱은 아프리카 녹색 원숭이의 폐에서 SARS-CoV-2 감염 역학을 보여줍니다Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey African green monkeys Alveolar macrophages Analysis animal model animal models animals best Cell cellular debris clearance contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 dataset degrade determine Factor genomic RNA green monkeys Host Host immune response host response host responses identify immune cell population immune cell populations immune responses in vivo inactivated Indicator infected cell infected cells Infection infiltrating Inflammatory response information inoculated knowledge lung Lungs Lymph node Macrophage macrophages mediastinal lymph nodes Mild mild to moderate moderate monocyte Monocyte-derived macrophages occur Pathogenesis phagocytosis pneumocyte Pneumocytes provide recruited replicate Replication respiratory respiratory tract responsible reveal RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data severe acute respiratory syndrome Coronavirus Single-cell RNA sequencing switching therapeutic targets valuable resource Viral viral genome viral replication virus virus replication while [DOI] 10.1126/scitranslmed.abe8146 PMC 바로가기 [Article Type] Research Article
Psychological burden of the COVID-19 pandemic and its associated factors among frontline doctors of Bangladesh: a cross-sectional studyResearch Article Published on 2021-01-112022-10-31 Journal: F1000Research [Category] COVID-19, MERS, [키워드] Analysis Anxiety Bangladesh co-morbidity collected community transmission condition contributing to convenience sampling counseling country COVID-19 COVID-19 pandemic COVID-19 patient cross-sectional demonstrated Depression Doctors evaluate Factor fear Health help high-risk population Inadequate Indicator Infection information Insomnia involved mental health Mild mitigate moderate multinomial logistic regression novel coronavirus disease pandemic poor mental health proportion Psychological psychological symptom psychological symptoms resource Risk factors Sleep Sleep disturbance smoking Treatment were assessed [DOI] 10.12688/f1000research.27189.3 PMC 바로가기 [Article Type] Research Article
Decreased CO 2 Levels as Indicators of Possible Mechanical Ventilation-Induced Hyperventilation in COVID-19 Patients: A Retrospective AnalysisCOVID-19 환자의 기계적 환기로 인한 과호흡 가능성의 지표로서의 CO 2 수준 감소: 후향적 분석Public Health Published on 2021-01-082022-09-11 Journal: Frontiers in Public Health [Category] MERS, 바이오마커, [키워드] 95% CI adjusted hazard ratio adjusted hazard ratios adjusted odds ratio Analysis caused clinical experience Clinical treatment CO2 collected Computed tomography conducted confidence interval coronavirus coronavirus disease correlated correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Cox regression Cox regression analysis Curve Decreased demonstrated determine disease severity higher risk hyperventilation Indicator Infectious disease information Kaplan-Meier curve Kaplan-Meier survival curve Kaplan-Meier survival curves Level log-rank test Mechanical mechanical ventilation medical record medical records Mortality mortality risk outbreak pandemic Patient Pneumonia Prognosis provide recommendations Survival curves the log-rank test the patient was used Wuhan [DOI] 10.3389/fpubh.2020.596168 PMC 바로가기 [Article Type] Public Health
Liver function recovery of COVID-19 patients after discharge, a follow-up studyResearch Paper Published on 2021-01-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] alanine aminotransferase ALB albumin alkaline phosphatase ALP ALT Aspartate aminotransferase AST AST/ALT cardiac function change Characteristics characterized China Clinical characteristics complications control group correlated COVID-19 patient COVID-19 patients COVID-19 pneumonia discharge discharge management discharged Diseases epidemiological Fatty liver Follow-up follow-up period follow-up study Glucose hemoglobin hospital Hospitalization immune Indicator Injury Intervention Laboratory leukocyte lipid metabolism Liver disease liver diseases Liver function Liver injury Long-term follow-up metabolism observé outlier Patient performed Platelet Protein remained renal function selected Shenzhen significant difference significant increase Symptoms thyroid function Treatment were assessed [DOI] 10.7150/ijms.50691 PMC 바로가기 [Article Type] Research Paper
D-Dimer as a Prognostic Indicator in Critically Ill Patients Hospitalized With COVID-19 in Leishenshan Hospital, Wuhan, ChinaPharmacology Published on 2020-12-212022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Admission Antibiotics anticoagulation cardiovascular disease Comorbidities conducted coronavirus disease COVID-19 critically ill patients D-dimer D-dimer level D-dimer levels death disease severity elevated Final Follow-up High-flow oxygen Ill Immunity increased mortality increased risk Indicator Infection intensive care interleukin-6 Lymphocytes marker median age Monocytes Mortality Patient patients with COVID-19 poor prognosis potential risk presenting previous study Prognosis prognostic indicator Protein provide reported Retrospective study SARS–CoV–2 significantly higher the patient Treatment underlying disease Wuhan, China [DOI] 10.3389/fphar.2020.600592 PMC 바로가기 [Article Type] Pharmacology