Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2SARS-CoV-2에 감염된 골든 시리아 햄스터의 폐에 있는 혈관염 및 호중구 세포외 트랩Immunology Published on 2021-04-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] alterations animal model animal models Antigen cause characterized contribute correlation COVID-19 COVID-19 pathogenesis COVID-19 patients days post infection disease edema endothelial damage extracellular trap FIBRIN hamster Human humans hyperplasia Infection infiltration Inflammation interstitial inflammation interstitial pneumonia lesion lung Lungs Macrophage macrophages NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils extracellular traps (NETs) Pathogenesis pulmonary pulmonary lesion pulmonary lesions resolved SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity shown These data Trigger Type II pneumocyte type II pneumocyte hyperplasia Vascular vascular lesion vascular lesions Vasculitis vessel virus [DOI] 10.3389/fimmu.2021.640842 PMC 바로가기 [Article Type] Immunology
Risk Factors and a Scoring System to Predict ARDS in Patients with COVID-19 Pneumonia in Korea: A Multicenter Cohort Study한국의 COVID-19 폐렴 환자에서 ARDS를 예측하는 위험 요인 및 점수 시스템: 다기관 코호트 연구Multicenter Study Published on 2021-04-092022-09-10 Journal: Disease Markers [Category] MERS, SARS, 바이오마커, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome age ARDS C-reactive protein CAPS characteristic Characteristics chest X-ray collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia determine diagnosed with COVID-19 enrolled epidemiological Factor FIVE form Health Organization infiltration investigated Logistic regression analysis neutrophil outcome Patient patients with COVID-19 Pneumonia predict prediction Predictive predictor progression provided receiver receiver operating characteristic report respiratory distress ROC score score cutoff Scoring sensitivity specificity syndrome System university hospital was performed with COVID-19 World Health Organization [DOI] 10.1155/2021/8821697 PMC 바로가기 [Article Type] Multicenter Study
Ivermectin reduces in vivo coronavirus infection in a mouse experimental modelArticle Published on 2021-03-302022-10-04 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] alanine aminotransferase Aspartate aminotransferase control group coronavirus diseases Coronavirus infection demonstrated disease Diseases Effectiveness euthanized general health status Health status hepatocellular histopathological in vivo infection levels infiltration Inflammatory Ivermectin liver Liver damage MHV MHV-A59 mice mouse hepatitis virus Necrosis PBS reduce RNA coronavirus SARS-CoV-2 serum transaminase significant difference significantly lower Signs and symptoms single dose therapy tissue treated Treatment viral infection Viral load were infected [DOI] 10.1038/s41598-021-86679-0 PMC 바로가기 [Article Type] Article
Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19COVID-19의 임상 형태에 대한 바이러스 게놈, 메타게놈 및 인간 전사체 특성화 및 예측Clinical Trial Published on 2021-03-292022-09-10 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] activate activating acute respiratory distress syndrome Acute respiratory failure Analysis antagonists Bacteria candidate Candidates caused Characteristics characterized clinical form collected COVID-19 COVID-19 pneumonia CXCR2 cytokine Diagnosis disease distress ENhance Factor feature female gender form fungi Genetic genomic high mortality rate Host identify IL-8 Immune cell immune cells infiltration Inflammatory response intensive care intensive care unit lower mortality metagenomic Mild Nasopharyngeal swab nasopharyngeal swabs neutrophil neutrophil infiltration outpatients overactive overexpression pandemic parasite parasites pathophysiology pathway Patient patients hospitalized Pneumonia pulmonary disease receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure respiratory symptom respiratory symptoms resulting SARS-CoV-2 Severe case severe COVID-19 Severe COVID-19 pneumonia severe pneumonia severity severity of COVID-19 shotgun syndrome T helper the disease tissue damage transcript transcriptomic transcriptomics Treatment turn upper respiratory Viral viruses was performed were used [DOI] 10.1371/journal.ppat.1009416 PMC 바로가기 [Article Type] Clinical Trial
Porcine Hemagglutinating Encephalomyelitis Virus Infection In Vivo and Ex VivoPathogenesis and Immunity Published on 2021-03-242022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] air-liquid interface respiratory epithelial cells Antibody Response Betacoronavirus cause CDCD (cesarean derived change characterized ciliated Clinical sign colostrum deprived) Concentration coronavirus Coronavirus infections Culture cytopathic detection rate did not produce disease Encephalomyelitis epithelia epithelial lining Ex vivo family Coronaviridae ganglia gastritis highest Human IFN-α IL-8 immune response Increased Infection infection process infiltration Inflammatory response inoculated Interferon alpha lesion liver Lungs lymph nodes Macrophage mild respiratory moderate nasal Neonatal neonatal pigs neurological pathogen Pathogenesis plasma platform porcine hemagglutinating encephalomyelitis virus primary site provide provided quantitative PCR respiratory cell respiratory tract RNA robust RT-qPCR secretion T lymphocyte threshold tissue tonsils tracheal tracheobronchial transcriptase upper respiratory tract Viremia virus virus replication vomiting [DOI] 10.1128/JVI.02335-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disordersReview Published on 2021-03-182022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS, [키워드] adipocyte adipose Bone marrow CD105 CD14 CD34 CD45 CD73 Cell cell type chemokines chondrocyte conditions Coronavirus disease 2019 (COVID-19) COVID-19 criteria Crohn’s disease Culture Cytokines disease disorder disorders effective eligible evaluated exceptional expression feature global scientific community Graft versus host diseases (GVHD) GVHD HLA-DR homing Host identify Immune cell Immune-mediated immunomodulatory in vitro Infectious disease infiltration Inflammatory response involved ISCT lack leucocyte Mesenchymal stem/stromal cells (MSCs) Migration modulate molecular mechanism MSC MSCs multiple sclerosis Multiple sclerosis (MS) novel coronavirus disease Osteoarthritis Osteoarthritis (OA) over pathway Patient plasticity recent finding regulated released required Secretome signaling molecule Society Source suggested synergy target cell therapeutic Therapeutic molecule therapeutic option tissue Treatment umbilical [DOI] 10.1186/s13287-021-02265-1 PMC 바로가기 [Article Type] Review
Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel DiseaseArticle Published on 2021-03-182023-08-30 Journal: Frontiers in Pediatrics [Category] E형 간염, [키워드] Crohn's disease infiltration Inflammatory bowel disease pediatric T cell trafficking ulcerative colitis [DOI] 10.3389/fped.2021.640497 PMC 바로가기
The networks of m 6 A-SARS-CoV-2 related genes and immune infiltration patterns in idiopathic pulmonary fibrosisResearch Paper Published on 2021-03-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] Algorithm Analysis association cells cellular characteristic CIBERSORT Cohort contribute coronavirus disease correlation COVID-19 COVID-19 infection COVID-19 pandemic Cox model dataset develop Diseases evaluated Gene Expression Gene Expression Omnibus gene expression pattern genetic link hazard identify Idiopathic pulmonary fibrosis immune immune cells immune infiltration immune response infiltration IPF Lung disease Methylation N6-methyladenosine operator Pathways patients Pearson correlation poor prognosis Prognosis pulmonary fibrosis regulated reported Research RNA modification SARS-CoV-2 SARS-COV-2 infection similarity tissue Treatment was obtained was performed was used were used [DOI] 10.18632/aging.202725 PMC 바로가기 [Article Type] Research Paper
Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomesArticle Published on 2021-03-112022-10-04 Journal: Scientific Reports [Category] 치료법, [키워드] ACE2 Analysis analyzed association biologic Cancer Cancer genomics cancer patient cancers Cell Clinical outcome correlated COVID-19 detrimental expressing expression Factor gene expression profile high variability identify in some in viral infiltration information involved large cohort malignant tumor natural killer other protease outcome Patient promote reveal RNA expression SARS-COV-2 infection subpopulation subset susceptibility T-cell target cells TMPRSS2 tumors Variability Viral reservoir Virology virus [DOI] 10.1038/s41598-021-84731-7 PMC 바로가기 [Article Type] Article
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody비만 세포 및 호산구 활성화는 COVID-19 및 TLR 매개 바이러스 염증과 관련이 있습니다: 항 Siglec-8 항체에 대한 시사점Immunology Published on 2021-03-102022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Activation administration airway Airway inflammation antibody caused cell activation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine deplete disease severity elevated eosinophil eosinophils excessive inflammation feature Health Health crisis hyperinflammation Hyperinflammatory Hyperinflammatory response Immune cell immune cells immune response immune responses implicated in vitro in vivo infiltration Inflammation Inflammatory responses inhibit innate immune cell Innate immune cells lirentelimab lung tissues mast cell Mast cells MCs mediators monoclonal antibody pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors protease Proteases reduced respiratory respiratory viral infection SARS-CoV-2 SARS-COV-2 infection sera Siglec-8 Stimulation suppressed Therapeutic approach Toll-like receptor Treatment Viral viral infection viral infections viral inflammation Viral RNA with COVID-19 [DOI] 10.3389/fimmu.2021.650331 PMC 바로가기 [Article Type] Immunology