Flipped Inflammatory Time and the Role of Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: Optimizing Tocilizumab Against Coronavirus Disease 2019뒤집힌 염증 시간과 중증 급성 호흡기 증후군에 대한 항체의 역할 코로나바이러스 2: 코로나바이러스 질병 2019에 대한 토실리주맙 최적화Article Published on 2022-08-122022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Against Anti-inflammatory effects autoantibodies benefit Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 disease dose driven by highest IL-6 IL-6 inhibition IL-6 inhibitor IL-6 inhibitors Immunopathogenesis inhibitor inhibitors innate immune system interferon interleukin mechanism of action modulate Mortality Open-label Patient Platform trial predict proinflammatory question Randomized respiratory risk role SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconvert serostatus severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein subgroup of patient therapy time Tocilizumab Treatment [DOI] 10.1093/infdis/jiac090 PMC 바로가기 [Article Type] Article
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
The Host Response to Influenza A Virus Interferes with SARS-CoV-2 Replication during CoinfectionArticle Published on 2022-08-102023-06-24 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 신종인플루엔자, [키워드] Anosmia Endemic H1N1 host response Interference interferon Long COVID pandemic PASC RNA sequencing [DOI] 10.1128/jvi.00765-22 PMC 바로가기
Interferon resistance of emerging SARS-CoV-2 variants새로운 SARS-CoV-2 변이체의 인터페론 내성Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] (Alpha) (Beta) Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Course COVID-19 COVID-19 pandemic Critical driving ENhance exhibited FIVE highlight implication include infections Innate immunity interferon interferon response interferons isolates lethality limit lineages Mutation neutralizing antibody outbreak P.1 Pathogenesis potency responses SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants spike spike mutations subtype the interferon Transmissibility Treatment Vaccine variant variants variants of concern Viral viral gene viral genes viral lineage virus infectivity while [DOI] 10.1073/pnas.2203760119 PMC 바로가기 [Article Type] Article
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translationSARS-CoV-2는 mRNA 번역의 NSP2 유도 억제를 통해 인터페론 생산을 손상시킵니다Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 4EHP Antiviral binding cellular cytokine Cytokines Depletion ENhance evade GIGYF2 IFN-β IFNB1 IFNs immunostimulatory impair inhibit innate immune response interact Interaction interferon interferons intrinsic mechanism mRNA mRNA translation mRNA translation. NSP2 Protein RNA viruses SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress target the SARS-CoV-2 the SARS-CoV-2 virus translation type I interferon type I interferons [DOI] 10.1073/pnas.2204539119 PMC 바로가기 [Article Type] Article
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
SARS-CoV-2 and Plasmodium falciparum Co-Infection in a Returning Traveler돌아오는 여행자의 SARS-CoV-2 및 Plasmodium falciparum 공동 감염Article Published on 2022-08-052022-09-11 Journal: Frontiers in Public Health [Category] SARS, 말라리아, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Anxiety Arbidol China Co-infection Compound coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Diagnosis diazepam dihydroartemisinin discharge discharged Diseases Evidence evidence of health system Healthcare system Hospitalization hydrochloride inflammatory reactions Insomnia interferon Lopinavir LOPINAVIR AND RITONAVIR malaria Mental no evidence of offer P. falciparum pandemic Paroxetine Paroxetine Hydrochloride Piperaquine Plasmodium Plasmodium falciparum raise reported Ritonavir SARS-CoV-2 severe acute respiratory syndrome Coronavirus sub-Saharan Africa Tablet tablets Tartrate tested the patient thymosin Treatment vital sign zolpidem Zolpidem Tartrate [DOI] 10.3389/fpubh.2022.871374 PMC 바로가기 [Article Type] Article
Interferon α-2b spray shortened viral shedding time of SARS-CoV-2 Omicron variant: An open prospective cohort study인터페론 α-2b 스프레이는 SARS-CoV-2 오미크론 변이체의 바이러스 배출 시간을 단축: 공개 전향 코호트 연구Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] 95% CI administration adverse effect against SARS-CoV Analysis antiviral activity China Cohort cohort study control group COVID-19 Effect Effectiveness enrolled examined experimental group first positive IFN IFN α IFN α-2b spray interferon less omicron Omicron variant participant Patient prospective cohort study protective effect protective factor SARS-CoV-2 SARS-CoV-2 Omicron variant SARS-CoV-2 variant Shanghai shown significantly spray Spread subgroup analysis the median treatment effect treatment effects univariate Cox regression univariate Cox regression analysis Vaccine viral shedding viral shedding time virus clearance virus transmission [DOI] 10.3389/fimmu.2022.967716 PMC 바로가기 [Article Type] Article
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisCOVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석Meta-Analysis Published on 2022-08-032022-09-11 Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood [DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis