COVID-19 acute respiratory distress syndrome: A simulation study of the effects of combination therapy with tocilizumab and siltuximabCOVID-19 급성 호흡곤란 증후군: 토실리주맙과 실툭시맙 병용 요법의 효과에 대한 시뮬레이션 연구Article Published on 2022-03-012022-09-12 Journal: British Journal of Clinical Pharmacology [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS binding binding constant blockade Bronchoalveolar lavage fluid combination therapy complex component Concentration COVID-19 COVID-19 patient develop Effect generate greater IL-6 IL-6 antagonist IL-6 level IL-6 receptor IL-6R interleukin-6 Intervention literature lung Model modelling monotherapy normal predict predicted reduced reduction reflect risk SARS-COV-2 infection sequestering sIL-6R siltuximab Simulation subject subjects syndrome targets TCZ Tocilizumab treat Treatment were used [DOI] 10.1111/bcp.15009 PMC 바로가기 [Article Type] Article
Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failureSCOPE 점수의 개발 및 검증: COVID-19 폐렴이 중증 호흡부전으로 진행되는 것을 예측하기 위한 임상 점수Article Published on 2022-02-252022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] Accuracy alternative Biomarkers C-reactive protein can be used circulating cohorts comparable Concentration COVID-19 D dimers death develop development disease Disease progression estimate excessive inflammatory response ferritin Hospital admission independent infected with SARS-CoV-2 interleukin interleukin-6 Invasive mechanical ventilation Mild MOST Most patients Non-invasive non-specific offer Patient plasma concentration Pneumonia predict prediction Predictive progression Receiver operator characteristic receiving receptor Respiratory failure SARS-CoV-2 SAVE-MORE study severe respiratory failure severe symptom severe symptoms soluble urokinase plasminogen activator receptor soluble urokinase plasminogen activator receptor. SRF suPAR Symptoms Treatment [DOI] 10.1016/j.xcrm.2022.100560 PMC 바로가기 [Article Type] Article
A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2하이브리드 가용성 gp130/스파이크-나노바디 융합 단백질은 SARS-CoV-2로 인터루킨-6 트랜스-시그널링 및 세포 감염을 동시에 차단합니다Article Published on 2022-02-232022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome addition age anti-inflammatory therapies antibody Antiviral approved assays bind block Cell Clinical use Comorbidities complexes Concentration coronavirus coronavirus disease COVID-19 cytokine receptor Cytokine storm diabetes disease pathology effective fused fusing fusion Glucocorticoid treatment high affinity higher risk hybrid hyperinflammation IL-6 IL-6 receptor IL-6R Immunocompromised patient individual induce infected individuals infected patients Infection inhibitor inhibitors intensive care interleukin-6 life-threatening Lung disease Mild monoclonal antibody monoclonal antibody treatment Multiorgan nanobody pandemic Patient patients Phosphorylation Prevent proliferation Protein RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe COVID-19 sgp130 shown Signaling sIL-6R soluble IL-6R Spike protein STAT3 Symptoms symptoms of COVID-19 the SARS-CoV-2 the spike protein therapeutic options therapy trans-signaling trans-signaling. treat Vero cells viral cell viral infection virus-induced hyperinflammation [DOI] 10.1128/JVI.01622-21 PMC 바로가기 [Article Type] Article
A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic ApplicationReview Published on 2022-02-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] alpha-1 antitrypsin alpha-1 antitrypsin deficiency anti-inflammatory activity antitrypsin application binding canonical Cell changes in circulation cleavage Complement C3 complex Coronavirus disease 2019 (COVID-19) Critical cytokine Cytokines disorder electrostatic hydrophobic immune response immunomodulatory increasingly innate immune interactions interleukin-6 mechanism methionine modulate molecular neutralise partner Potential protease Proteases Protein protein-protein interaction reactive residue review serine protease inhibitor therapeutic therapy [DOI] 10.3390/ijms23052441 PMC 바로가기 [Article Type] Review
Are the Follicular Fluid Characteristics of Recovered Coronavirus Disease 2019 Patients Different From Those of Vaccinated Women Approaching in vitro Fertilization?Physiology Published on 2022-02-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Ala Analysis anti SARS-CoV-2 immunoglobulins antibody carried collected Combination control group coronavirus disease Covid patients COVID-19 dismutase evaluate FIVE Follicular fluid healthy healthy controls in vitro induce inflammatory proteins interleukin-6 Lipid metabolic effect metabolite metabolomic analysis metabolomics Necrosis nine NMR NMR spectroscopy Oocyte outcome participant pilot study Pro proinflammatory markers radical scavenger recovered recovered COVID-19 patient Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection selected significantly lower TNF-α TNFα trimethylamine vaccination was performed western blotting analysis women [DOI] 10.3389/fphys.2022.840109 PMC 바로가기 [Article Type] Physiology
Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implicationsSARS-CoV-2 ARDS의 프로테아제-항-프로테아제 구획화: 치료적 의미Articles Published on 2022-02-222022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome airway airways Alpha alpha-1 antitrypsin ARDS ARDS patients balance circulation cleavage cleaved detectable down-regulated Effect elevated evaluated finding IL-6 IL-6 level IL-6 receptor implication induction inhibitor interleukin interleukin-6 investigated involved less Level lung lung parenchyma moderate NET neutrophil Neutrophil elastase Neutrophils occurred patients plasma protease Proteins receptor antagonist regulate respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection secretion Standard of care syndrome target therapy tissue Tocilizumab tracheal were measured [DOI] 10.1016/j.ebiom.2022.103894 PMC 바로가기 [Article Type] Articles
Tocilizumab and COVID-19: Timing of Administration and EfficacyPharmacology Published on 2022-02-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome Admission Concentration Corticosteroids COVID-19 COVID-19 infection COVID-19 pandemic Cytokine storm demonstrated described Effect Efficacy and safety Evidence highlighting Host humanized monoclonal antibody immune immune dysregulation immunomodulatory impairment Infection intensive care intensive care unit interleukin-6 interleukin-6 receptor interleukine -6 receptor antagonist Intervention Invasive mechanical ventilation investigated key factor mechanical ventilation Mortality observational study outcome pathophysiology patients patients with COVID-19 Pneumonia positive result Potential treatment Prognostic factor Proinflammatory response Randomized controlled trial reported risk SARS-COV-2 infection selected shown Standard of care Support therapy Tocilizumab with COVID-19 [DOI] 10.3389/fphar.2022.825749 PMC 바로가기 [Article Type] Pharmacology
Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment키토산으로 코팅된 실리마린/커큐민 로딩 알부민 나노입자는 올레산 유발 폐 손상 및 시험관 내 COVID-19 실험에서 항염증 및 항 COVID-19 특성을 관찰하는 점막 흡입성 전달 시스템Article Published on 2022-02-152022-09-11 Journal: International journal of biological macromolecules [Category] 비임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome albumin alveolar Anti-inflammatory anti-viral activity assembly bovine bovine serum albumin BSA C-reactive protein can be used candidate chitosan coated coronavirus COVID-19 edema Efficacy ENhance experiment Health health problem hyaline membrane hyaline membranes hyperplasia identify in vitro infected patient infected patients Inflammation inflammatory process interleukin interleukin-6 Lung injury lung lesion lung lesions moment Mucoadhesive. oleic acid overcome Pneumonia Polymer Protein reduction in respiratory respiratory distress Respiratory distress syndrome septal serum albumin silymarin syndrome treated Treatment treatment of COVID-19 triggered virus [DOI] 10.1016/j.ijbiomac.2021.12.073 PMC 바로가기 [Article Type] Article
Increased Circulating Cytokines Have a Role in COVID-19 Severity and Death With a More Pronounced Effect in Males: A Systematic Review and Meta-AnalysisPharmacology Published on 2022-02-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome article Asian caused circulating claimed coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity COVID-2019 cytokine Cytokines Cytokines storm death death group demonstrated driving Effect elevated Epidemic European Evidence Factor females groups high mortality identify IL-10 IL-17 IL-1β IL-4 IL-6 IL-8 Increased increased mortality Inflammatory cytokine interleukin-6 key factor male Meta-analysis Mortality much higher Necrosis non-survivor Patient patients potential risk predisposition receptor review risk of bia role SARS-CoV-2 screened searched Serum level severity Sex Sex bias significantly the mean TNF-α upregulation Web of Science were measured [DOI] 10.3389/fphar.2022.802228 PMC 바로가기 [Article Type] Pharmacology
Circulating Type I Interferon Levels in the Early Phase of COVID-19 Are Associated With the Development of Respiratory FailureObservational Study Published on 2022-02-142022-10-04 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] Analysis association Blood chemokine circulation collected correlated COVID-19 CXCL10 development early phase ELISA enrolled evaluate failure Hypoxemia hypoxemic IFN-I IFN-α IFN-β IFNs IL-6 interferon-alpha Interferon-beta interleukin-6 Invasion Level Ligand motif objective onset of symptoms Patient patients hospitalized patients with COVID-19 phase Pneumonia prospective observational study qPCR recruited respiratory Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load serum Serum level significantly significantly higher specimen symptom onset systemic immune response Type type I interferon Viral load was determined were measured with COVID-19 [DOI] 10.3389/fimmu.2022.844304 PMC 바로가기 [Article Type] Observational Study