Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa플라스모디움 팔시파룸 hrp2 유전자 결실의 확산 요인 모델링: 사하라 이남 아프리카에서Article Published on 2017-08-242024-08-12 Journal: eLife [Category] 말라리아, [키워드] mapping Mathematical modelling P. falciparum pfhrp2-deletion Rapid diagnostic tests [DOI] 10.7554/eLife.25008 PMC 바로가기
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease심혈관 질환의 83개 혈장 단백질 바이오마커에 대한 79개 유전자좌 매핑Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis approach association associations Author automated Biomarker Blood blood concentration bystander can be used cardiovascular disease cause Cell classic Combination Concentration Coronary artery Coronary artery disease correlation CVD determine disease Epidemiology eQTL evaluate Evidence evidence of expression expression quantitative trait loci Genetic genetic regulation Genetic variant genetic variants genome-wide association genome-wide significant genotyping GWA higher risk highlight human disease identify implicated individual individuals information involved knowledge large cohort leads Ligand loci majority manual curation mapping matrix metalloproteinase mechanism multiplexed immunoassay novel offer plasma plasma protein plasma proteins Protein protein expression protein level protein levels Proteins provide Quantitative RANK recent regulate Regulation Regulatory replicated risk Risk factors stem cell stem cell factor targets text mining the disease turn upstream validation study variant [DOI] 10.1371/journal.pgen.1006706 PMC 바로가기 [Article Type] Research Article
Mapping of Malaria Vectors at District Level in India: Changing Scenario and Identified GapsArticle Published on 2017-02-282024-09-09 Journal: Vector Borne Zoonotic Dis [Category] 말라리아, [키워드] Anopheles District India malaria mapping vectors. PMC 바로가기
Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel lociMHC 너머: 피부근염의 송곳니 모델은 새로운 유전자좌와 관련된 유전적 위험의 복잡한 패턴을 보여줍니다Research Article Published on 2017-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affected age of onset alleles allelic combination animal model artificial selection association Autoimmune disease biological samples canine chromosome chromosomes Combination complex complex disease complex diseases components conducted conserved conserved regions contribute correlated dermatomyositis disease disease pathogenesis Disease progression disease risk driven by dysfunction encoding Evidence explain exploration Frequency gene-gene interaction Genetic genetic interactions genetic risk genetic risk factor genetic study Genome Genome-wide association studies Genome-wide association study Genotype genotype-phenotype correlation genotypic genotyping Haplotype haplotypes healthy heterogeneity high risk highlight homozygosity human populations identify immunological impacted incidence independent independent of indicated Inflammatory inflammatory disease influences Interaction inverse correlation investigated involved Isolation juvenile dermatomyositis loci major histocompatibility complex MAP3K7CL mapping MHC moderate muscle Myopathy nine PAN2 pattern Phenotypes polymorphism Probability provided Region risk risk allele skin subjects susceptibility susceptibility loci target targets the major histocompatibility thought unique utility Vasculopathy whole genome [DOI] 10.1371/journal.pgen.1006604 PMC 바로가기 [Article Type] Research Article
Automatic classification of registered clinical trials towards the Global Burden of Diseases taxonomy of diseases and injuriesResearch Article Published on 2016-09-222023-08-28 Journal: BMC Bioinformatics [Category] E형 간염, [키워드] clinical trials disease classification Global burden of diseases mapping [DOI] 10.1186/s12859-016-1247-7 PMC 바로가기 [Article Type] Research Article
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다Research Article Published on 2016-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses [DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력Research Article Published on 2016-03-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Affect Analysis anti-neutrophil cytoplasmic antibody association Autoimmune Autoimmune diseases blood cell blood vessel blood vessels bowel Cancer cell types cellular cellular activation clinical disease complex complex system contribute cytoplasmic damage database dependent on disease risk disease-associated loci DNA Effect eQTL eQTL analysis eQTL mapping eQTLs estimate examined Examining expression expression data expression quantitative trait loci FIVE Gene Expression Genetic genetic control Genetic studies Genetic variant genetic variants genetics Genome-wide association studies Gut GWAS healthy healthy control healthy controls help Human immune system human inflammatory diseases identifying immune Immune cell immune cell type immune cells immune-mediated diseases in vitro include Infection Inflammation Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases insight investigated joint knowledge leucocyte loci majority mapping Multiple observation Pathogenesis Patient performed proportion PROTECT provide Quantitative regions resulting risk specificity subset subtype tissue tissues Treatment Type variant Vasculitis White blood cell [DOI] 10.1371/journal.pgen.1005908 PMC 바로가기 [Article Type] Research Article
Spatially aggregated clusters and scattered smaller loci of elevated malaria vector density and human infection prevalence in urban Dar es Salaam, Tanzania도시 다르에스살람, 탄자니아에서 말라리아 매개체 밀도와 인간 감염 유병률이 높아진 공간적으로 집계된 클러스터와 흩어진 작은 위치Research Published on 2016-03-012024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Anopheles gambiae Hotspots malaria mapping Mosquito Plasmodium falciparum Spatial clustering [DOI] 10.1186/s12936-016-1186-9 PMC 바로가기 [Article Type] Research
Factors influencing the spatial distribution of Anopheles larvae in Coimbatore District, Tamil Nadu, Indiaarticle Published on 2015-12-312024-09-01 Journal: Family process [Category] 말라리아, [키워드] Anopheles ArcGIS larval density Larval habitats mapping [Article Type] article
Malaria mapping: understanding the global endemicity of falciparum and vivax malaria말라리아 지도화: 팔시파룸 및 비박스 말라리아의 전 세계 풍토병 이해Article Published on 2015-06-122024-08-13 Journal: BMC Medicine [Category] 말라리아, [키워드] Falciparum malaria mapping model-based geostatistics modelling Vivax [DOI] 10.1186/s12916-015-0372-x PMC 바로가기