Measuring vaccine efficacy against infection and disease in clinical trials: sources and magnitude of bias in COVID-19 vaccine efficacy estimates임상 시험에서 감염 및 질병에 대한 백신 효능 측정: COVID-19 백신 효능 추정치의 편향 출처 및 규모Major Article Published on 2021-10-262022-09-10 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] Ad26 Ad26.COV2.S antibodies approaches arise Asymptomatic asymptomatic infection asymptomatic infections bias biases breakthrough infections ChAdOx1 changes in Characteristics clinical trial competing COVID-19 COVID-19 vaccine direction disease Effectiveness Efficacy estimate estimates expected implication indicate Infection janssen less magnitude mathematical mathematical model Multiple Oxford-AstraZeneca PCR performed phase Phase III trials Prevent PROTECT Result SARS-CoV-2 Sensitivity and specificity serology serostatus specificity Symptom symptomatic symptomatic and asymptomatic symptomatic infection symptomatic infections the vaccine Trial Vaccine vaccine efficacy Vaccine-induced immunity Vaccines [DOI] 10.1093/cid/ciab914 PMC 바로가기 [Article Type] Major Article
OutbreakFlow: Model-based Bayesian inference of disease outbreak dynamics with invertible neural networks and its application to the COVID-19 pandemics in GermanyResearch Article Published on 2021-10-252022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, [키워드] application Applying approach Bayesian Bayesian inference Characteristics circumvent Combination Complete complex concerning COVID-19 data integrity determine disease Diseases distribution Epidemic epidemiological Epidemiology estimate expressive flexible fraction Generation time Germany infected individual Infection infections initial joint knowledge likelihood mathematical mathematical model measure moderate observation outbreak Pandemics parameter parameters predict progression proportion Public health interventions quantification repeated subsequent symptom onset the epidemic Transmission variety [DOI] 10.1371/journal.pcbi.1009472 PMC 바로가기 [Article Type] Research Article
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models세 가지 전임상 모델에서 COVA1-18 중화 항체가 SARS-CoV-2로부터 보호Article Published on 2021-10-202022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome coronavirus Administered animal model antibody antiviral activity B.1.1.7 B.1.1.7 isolate cause clinical evaluation coronavirus COVID-19 patients cynomolgus macaques Efficacy evaluate hACE2 hamsters High dose Immunotherapy in vivo Infectious diseases lung lung lesions Lungs lymphopenia macaque mathematical mathematical model mice monoclonal antibodies neutralizing antibody patients Preclinical research Prophylactic PROTECT reduce reduction in respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown therapeutic therapeutic effect Therapeutic treatment treated Treatment undetectable upper respiratory upper respiratory tract Viral viral infectivity Viral load viral loads [DOI] 10.1038/s41467-021-26354-0 PMC 바로가기 [Article Type] Article
Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism케냐의 COVID-19 전파에 대한 수학적 모델링: 재감염 전파 메커니즘이 있는 모델Research Article Published on 2021-10-162022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, SARS, 치료기술, [키워드] Admission Alter Asymptomatic Asymptomatic case Asymptomatic cases Asymptomatic individuals Contact tracing coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 Critically ill cumulative dataset deaths detection rate Face masks fitting increase in individual infectious intensive care Kenya lead mathematical mathematical model Mild symptom mild symptoms Model pandemic parameter pharmaceutical intervention Prevalence proliferation protective immunity reduce Reinfection reported severe symptom severe symptoms subpopulation symptomatic symptomatic individual symptomatic individuals wearing face mask with COVID-19 [DOI] 10.1155/2021/5384481 PMC 바로가기 [Article Type] Research Article
The use of face masks during vaccine roll-out in New YorkCity and impact on epidemic control뉴욕시에서 백신이 출시되는 동안 안면 마스크 사용과 전염병 통제에 미치는 영향Article Published on 2021-10-082022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] accounted booster calibrated can not commenced Complete Coverage COVID-19 death dosage effective Efficacy Epidemic epidemic curve face Face mask Face masks First wave FIVE greater Immunity increase in less Local lockdown Mask mask mandate Masks mathematical mathematical model mitigate New New York New York City NPI NPIs outbreak reduce SARS-CoV-2 transmission SEIR suppressed tested the epidemic time lag tracing trajectory Transmission vaccination Vaccine vaccine efficacy variants variants of concern [DOI] 10.1016/j.vaccine.2021.08.102 PMC 바로가기 [Article Type] Article
Estimating epidemiologic dynamics from cross-sectional viral load distributions단면 바이러스 부하 분포에서 역학적 역학 추정Article Published on 2021-09-262022-09-12 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approach arising biases calibrated can be used Care Chain Reaction changes in collected conducted coronavirus Course cross cross-sectional Ct values current cycle threshold death declining develop Diseases distribution emerging viruses Epidemic estimate feature flexible framework growth growth rate highlight Hospital admission hospitalizations implication IMPROVE incidence individual individuals infected individual Infection infection prevalence Infectious diseases information inherent Intervention Long-term care management Massachusett Massachusetts mathematical mathematical model Metrics offer Older outbreak overcome pandemic performed polymerase chain polymerase chain reaction population distribution populations positive Precision proportion proportions provide Public health response Public health responses Quantitative random Random sample rationale real time reflect reflected repeated reported Reporting reproductive reveal reverse transcription reverse transcription quantitative polymerase chain reaction rising robust robustness RT-qPCR sample collection SARS-CoV-2 SARS-CoV-2 testing severe acute respiratory syndrome Coronavirus specimen Surveillance surveillance data surveillance testing the epidemic the median trajectory turn understanding variant variants Variation variety viral kinetics Viral load viral loads virus [DOI] 10.1126/science.abh0635 PMC 바로가기 [Article Type] Article
Mathematical Modeling of Vaccines That Prevent SARS-CoV-2 TransmissionSARS-COV-2 전송을 방지하는 백신의 수학적 모델링Article Published on 2021-09-242022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] airway airways average B.1.1.7 B.1.1.7 variant BNT162b2 clinical trial clinical trials COVID-19 decrease defined demonstrated disease Efficacy epidemic wave explained herd immunity Herd immunity threshold Infection King limit log mathematical mathematical model mathematical modeling Metrics modeling Moderna number of infected participant Pfizer-BioNTech predicted preventing infection PROTECT reached recipients reduction in SARS-CoV-2 SARS-CoV-2 vaccine secondary transmission spring Symptom symptomatic symptomatic COVID-19 the vaccine the vaccines Transmissibility Vaccine vaccine efficacy Vaccines Viral viral dynamics viral kinetics Viral load virus Washington [DOI] 10.3390/v13101921 PMC 바로가기 [Article Type] Article
Reconstructing a COVID-19 outbreak within a religious group using social network analysis simulation in Korea한국의 소셜 네트워크 분석 시뮬레이션을 사용하여 종교 집단 내 COVID-19 발생 재구성COVID-19: Original Article Published on 2021-09-162022-09-11 Journal: Epidemiology and Health [Category] MERS, 치료기술, [키워드] 95% CI 95% confidence interval approach average baseline calibrated Cluster conducted Contact coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak develop Diseases effective Effectiveness experiment Government implication indicated Infectious diseases Interaction life Mask mathematical mathematical model measure network analysis organization other infectious diseases outbreak Outbreaks physical distancing potential benefit potential benefits reconstructed Simulation social distancing social network social network analysis Spread spread of COVID-19 Standard deviation susceptible was used [DOI] 10.4178/epih.e2021068 PMC 바로가기 [Article Type] COVID-19: Original Article
Assessing the impact of widespread respirator use in curtailing COVID-19 transmission in the USAMathematics Published on 2021-09-082022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Assessing baseline baseline level cloth masks Community community transmission Compliance COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 transmission Daily disease dynamic effective eliminated Face mask face masks and respirators healthy highlight Immunity include increase in Intervention maintain Mask mathematical model moderate natural immunity non-pharmaceutical and pharmaceutical interventions NPI NPIs outbreak pandemic Pandemics Prevent public health recorded reduce reducing Respirator Respiratory disease SARS-CoV-2 severity significantly subsequent surgical the epidemic USA Vaccine Vaccines widespread [DOI] 10.1098/rsos.210699 PMC 바로가기 [Article Type] Mathematics
Risk of COVID-19 transmission in heterogeneous age groups and effective vaccination strategy in Korea: a mathematical modeling study이질적인 연령대의 COVID-19 전파 위험과 한국의 효과적인 예방 접종 전략: 수학적 모델링 연구COVID 19: Original Article Published on 2021-09-082022-09-11 Journal: Epidemiology and Health [Category] MERS, 변종, [키워드] age condition conducted COVID-19 COVID-19 transmission effective FIVE group groups heterogeneous high risk Infection lower risk maintain mathematical mathematical model maximum likelihood estimation Mortality Older age outbreak physical distancing Prevent reached reproductive Republic of Korea social distancing the epidemic Theoretical models total population Transmission transmission rate vaccination Vaccination strategy Vaccine variants was used worsened [DOI] 10.4178/epih.e2021059 PMC 바로가기 [Article Type] COVID 19: Original Article