A Portable Nanoprobe for Rapid and Sensitive Detection of SARS-CoV-2 S1 ProteinSARS-CoV-2 S1 단백질의 신속하고 민감한 검출을 위한 휴대용 나노프로브Article Published on 2022-04-112022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 receptor applied clinical sample clinical samples complementary contaminated surface contaminated surfaces coronavirus COVID-19 COVID-19 infection detect detection Detection limit diagnostic eliminating generate help Infectious virus inherent Laboratory Laboratory report lactoferrin linear low-cost diagnostic assay MERS MERS-CoV onsite detection optical PCR testing positive result quantitation Rapid rapid biosensors. receptor SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike protein sensitive simple Spike protein the SARS-CoV-2 zone [DOI] 10.3390/bios12040232 PMC 바로가기 [Article Type] Article
Th2-Oriented Immune Serum After SARS-CoV-2 Vaccination Does Not Enhance Infection In VitroSARS-CoV-2 백신 접종 후 Th2 지향 면역 혈청은 시험관 내 감염을 증가시키지 않습니다Article Published on 2022-04-082022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied acute respiratory syndrome ADE Adjustment adjuvant aluminum aluminum adjuvant Antibody-dependent enhancement antibody-dependent enhancement of infection Antigen cell line coronavirus Efficacy examined expression pattern Fc receptors Human immune Immune cell immunization immunopathology in vitro inactivated Inactivated SARS-CoV-2 vaccine Infection infiltration lung MERS-CoV mice Middle East neutralizing antibody Neutralizing antibody titer preclinical study Pseudotyped virus respiratory syndrome coronavirus response risk S1 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 virus sera serum Spike protein spike protein subunit vaccine. subunit T helper tested Th2 the SARS-CoV-2 Vaccine virus [DOI] 10.3389/fimmu.2022.882856 PMC 바로가기 [Article Type] Article
Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachMERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses [DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain스파이크 수용체 결합 도메인의 특정 에피토프를 표적으로 하는 단일클론항체에 의한 SARS-CoV-2 감염의 중화 또는 증강Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody-dependent enhancement binding binding epitope caused cellular contrary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity Delta demonstrated dose-dependent manner ELISA epitope Epitopes Epsilon exhibited exhibiting experiment Gamma HEK293T cells Infection lentivirus MERS-CoV monoclonal antibodies monoclonal antibody mouse monoclonal antibody NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic Protein pseudotyped RBD receptor Receptor binding domain Receptor-binding domain reduction Region reported residue residues respiratory S protein S proteins SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike receptor binding domain Spike receptor binding domain. spike receptor-binding domain the RBD the receptor-binding domain the S protein Therapeutic treatment variant variants of SARS-CoV-2 wild-type [DOI] 10.1016/j.antiviral.2022.105290 PMC 바로가기 [Article Type] Article
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus [DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article
Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and Prolixin RX (Fluphenazine) Provides Off-Label Drug CandidatesReview Published on 2022-03-292023-06-15 Journal: SLAS discovery : advancing life sciences R & D [Category] MERS, SARS, [키워드] MERS-CoV Prolixin SARS-CoV SARS-CoV-2 Sinigrin systematic review [DOI] 10.1177/2472555220950236 PMC 바로가기 [Article Type] Review
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunityArticle Published on 2022-03-252022-11-01 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] accessory protein adapter Alter binding binding domain binding mechanism biochemically canonical coronavirus Edward explain high-resolution structure highly pathogenic Host Immunity impair infected cells inhibiting innate immune innate immune response innate immune responses Innate immunity Interaction lack mechanism MERS coronavirus MERS-CoV Mutation NF-κB NLS nuclear nuclear translocation ORF4b overlap P50 Protein shown signaling pathways Structure viral infection virus Virus-host interactions X-ray crystallography [DOI] 10.1038/s41467-022-28851-2 PMC 바로가기 [Article Type] Article
Inhibition of the IFN-α JAK/STAT Pathway by MERS-CoV and SARS-CoV-1 Proteins in Human Epithelial CellsArticle Published on 2022-03-232023-06-15 Journal: Viruses [Category] MERS, SARS, [키워드] immune evasion interferon-alpha ISG (interferon stimulated genes) JAK/STAT (janus kinase/signal transducer and activator of transcription) MERS-CoV SARS-CoV-1 SARS-CoV-2 [DOI] 10.3390/v14040667 PMC 바로가기 [Article Type] Article
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in miceResearch Article Published on 2022-03-222022-10-04 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 치료제, [키워드] acute respiratory syndrome administration Antiviral antiviral activity antivirals approval Breakthrough infection conserved coronavirus coronavirus disease CoV COVID-19 Culture description develop dose-dependent drug effective EUA exhibited GS-441524 in vitro in vivo increasingly infected with SARS-CoV-2 Infection lung lung cell lung cell line MERS-CoV mice Middle East molnupiravir monoclonal antibodies neutralization outpatients pandemic parent nucleoside parental pharmacokinetic Protective Pulmonary function reduced Remdesivir respiratory RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant Support target therapeutic therapeutic efficacy translated Treatment vaccination Vaccines Viral load Viral protein virus waning immunity [DOI] 10.1126/scitranslmed.abm3410 PMC 바로가기 [Article Type] Research Article