Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-CSARS-CoV-2 오미크론 변이체에 대한 교차 반응성 면역은 이전에 COVID-19 또는 MIS-C가 있는 소아 환자에서 낮습니다.Article Published on 2022-05-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute COVID-19 age Alpha Analysis antibody Antibody titers Beta children clinical disease Cohort convalescent COVID-19 cross-neutralization Delta demonstrated evaluated expected Gamma Hospitalized Immunity less Mild MIS-C neutralization neutralization capacity neutralization titer Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers neutralizing capacity omicron Omicron variants outcome Outpatient outpatients Patient patients pediatric Pediatric patient Re-infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Support the SARS-CoV-2 Transmission vaccination variant variants virus-neutralizing [DOI] 10.1038/s41467-022-30649-1 PMC 바로가기 [Article Type] Article
An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease인공 지능 유도 서명은 MIS-C 및 가와사키병에서 공유된 숙주 면역 반응을 나타냅니다.Article Published on 2022-05-162022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료법, [키워드] artificial cardiac function children clinical feature continuum COVID-19 COVID-19 pandemic cytokine Cytokine storm demonstrated diagnostic fixed formalin gene signature Host immune response Inflammatory Kawasaki disease Laboratory laboratory parameter MIS-C MONITOR pandemic parameter pathway pediatric Phenotypes proximal reduced Result reveal RNA sequences SARS-COV-2 infection serum cytokines severity syndrome tissues unique Whole blood [DOI] 10.1038/s41467-022-30357-w PMC 바로가기 [Article Type] Article
MIS-C Triggered by Omicron Variant of SARS-CoV-2SARS-CoV-2의 오미크론 변종에 의해 유발된 MIS-CArticle Published on 2022-05-152022-09-11 Journal: Indian pediatrics [Category] COVID19(2023년), SARS, 변종, [키워드] MIS-C omicron SARS-CoV-2 [DOI] 10.1007/s13312-022-2526-1 PMC 바로가기 [Article Type] Article
Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children중동의 소아 다기관 염증 증후군 환자의 유전적 및 임상적 특성Multicenter Study Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age Asian association attributes children clinical Clinical characteristics Clinical course Clinical outcome clinical outcomes cohort study complications conducted contribute Control control group controls Deleterious disease disease entity disease onset dose dysregulated Exome Fisher exact test Genetic genetic finding genetic findings Genetic variant genetic variants healthy children heterozygous variant identify IFNA6 IFNB1 IL22RA2 immune-related genes Immunoglobulin Inflammatory Inflammatory marker inflammatory markers Intravenous immunoglobulin Jordan laboratory biomarkers laboratory characteristics male manifestation Mann-Whitney U test matched control middle Middle East MIS-C multicenter cohort study neurologic organ organ system outcome participant participated Patient Population recruited reported SARS-CoV-2 SARS-COV-2 infection Sequencing significantly syndrome TLR3 TLR6 Treatment United Arab Emirate United Arab Emirates variant variants was performed was used were measured [DOI] 10.1001/jamanetworkopen.2022.14985 PMC 바로가기 [Article Type] Multicenter Study
The clinical features and estimated incidence of MIS-C in Cape Town, South Africa남아프리카 케이프타운에서 MIS-C의 임상적 특징 및 추정 발생률Article Published on 2022-05-022022-09-12 Journal: BMC Pediatrics [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abdominal pain Affect age Analysis black calculated Cape cardiac children children with MIS-C clinical clinical feature clinical manifestation Coagulation Cohort collected comparison CRP D-dimer deaths demographic data Diagnosis eight Epidemiology ferritin Fever fibrinogen global health Haemoglobin healthy children highlight hospital Hospital stay ICU admission immune incidence independent Infection Inflammatory intravenous invasive ventilation involved lack Logistic regression Low-middle income countries marker median median age Methylprednisolone MIS-C neutrophil count organ system outcome Oxygen therapy paediatrics pandemic performed Peritoneal dialysis Rash recruited renal required SARS-CoV-2 SARS-CoV-2 antibodies serum Seven sodium South Africa Support Surveillance syndrome Tachycardia the healthy town Treatment was tested white cell [DOI] 10.1186/s12887-022-03308-z PMC 바로가기 [Article Type] Article
Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-CCOVID-19 유도 MIS-C와 비교하여 COVID-19 ARDS가 있는 어린이의 병태생리학적 경로 차이Article Published on 2022-05-022022-09-11 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, 임상, 치료법, [키워드] Activation affected Analysis ARDS BCR children children with COVID-19 clinical feature Clinical features clinical phenotypes Coagulation complement contribute COVID COVID-19 described determine differentially expressed dysregulation expressed groups healthy children implicated Inflammatory less mass mass spectrometry metabolism MIS-C pathway Pathways performed plasma protein Protein proteomic proteomics retinoid scavenging Spectrometry susceptible Symptoms syndrome with COVID-19 [DOI] 10.1038/s41467-022-29951-9 PMC 바로가기 [Article Type] Article
Allogeneic Hematopoietic Stem Cell Transplant for Acute Lymphoblastic Leukemia in a Pediatric Patient After COVID-19 Infection Complicated by MIS-CShort communication Published on 2022-05-012022-10-05 Journal: Journal of pediatric health care : official public [Category] 바이오마커, [키워드] Care Case report Chemotherapy children Clinical course Course COVID-19 COVID-19 infection COVID-19 pandemic disease disease course hematopoietic Hematopoietic stem cell transplant impacted implication individuals Infection Inflammatory initial knowledge lack leukemia MIS-C oncology oncology patients outcome Patient pediatric pediatrics recommendation Research risk STEM Stem cell transplantation syndrome the disease Transplant Treatment [DOI] 10.1016/j.pedhc.2022.01.006 [Article Type] Short communication
Multisystem Inflammatory Syndrome in Children after SARS-CoV-2 VaccinationArticle Published on 2022-05-012023-07-08 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), [키워드] COVID-19 COVID-19 vaccine MIS-C multisystem inflammatory syndrome in children respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 United States Vaccines viruses zoonoses [DOI] 10.3201/eid2805.212418 PMC 바로가기
Reported cases of multisystem inflammatory syndrome in children aged 12-20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation2020년 12월부터 2021년 8월까지 COVID-19 백신을 접종한 미국의 12-20세 어린이에서 보고된 다기관 염증 증후군 사례: 감시 조사Article Published on 2022-05-012022-09-11 Journal: The Lancet. Child & adolescent health [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] Adverse age Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike antibody assessment calculate CDC center children clinical clinical feature clinician Control count COVID-19 vaccination COVID-19 vaccine discharged home disease control dose drug Drug administration eight Emergency use Evidence evidence of female food Hyperinflammatory illness illness onset individual individuals Infection Inflammatory intensive care intensive care unit investigated Laboratory male median age MIS-C National past positive prevention Protein receiving reported Reporting required Safety SARS-CoV-2 SARS-COV-2 infection serology test stratified Surveillance surveillance data syndrome System US Food and Drug Administration USA vaccinated individuals vaccination Vaccine [DOI] 10.1016/S2352-4642(22)00028-1 PMC 바로가기 [Article Type] Article
Signs of Cardiac Injury in Critically Ill Paediatric Patients with COVID-19: a Single-Center Experience in BrazilCOVID-19 소아 중환자의 심장 손상 징후: 브라질의 단일 센터 경험Article Published on 2022-05-012022-09-11 Journal: Arquivos Brasileiros de Cardiologia [Category] MERS, 바이오마커, [키워드] 95% CI abnormality acute respiratory syndrome Admission Brazil cardiac cardiac injury cardiac troponin Cardiac troponin I cardiovascular children COVID-19 Critically ill detect Echocardiogram elevated English enrolled experience help Ill Inflammatory Injury intensive care MIS-C mitral multisystemic myocardial injury Negative predictive value pacientes com COVID-19 paediatric patients para Patient patients patients with COVID-19 pericardial effusion predictive values raised respiratory SARS patients Severe acute respiratory syndrome SIGN statistical analysis Support syndrome troponin I two-dimensional two-sided [DOI] 10.36660/abc.20210200 PMC 바로가기 [Article Type] Article