Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications수용체가 장착된 Virion은 GPCR 신호 전달을 위험에 빠뜨립니다: SARS-CoV-2 감염 및 약리학적 의미의 기계적 탐색Review Published on 2021-10-112022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor alleviate antibody Antibody therapy arrestin binding Brain Cell cell junction cellular response COVID-19 demonstrated disrupting Disruption distribution drug Drug development E protein ENhance exploration GPCR signaling hematogenous host cells impair Infection interact Interaction intestine Invasion kidney Loss of Smell loss of smell and taste lung Lungs membrane motif multiorgan injury multiple organs NRP1 other organ other organs PALS1 pathogenic PDZ interaction penetration Protein receptor required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections susceptible Taste therapeutic strategy therapy tissue Viral viral cell entry viral endocytosis viral invasion virion virtue ZO-1 [DOI] 10.3390/ijms222010963 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathwayOriginal Article Published on 2021-10-082022-10-30 Journal: MedComm [Category] COVID-19, [키워드] abrogation ACE2 addition approach bind binding Critical decrease defined Degradation Depletion docking domain endocytic endocytic trafficking endosomal trafficking endosome expression facilitate Factor Genetic highlight Host host cells host–pathogen interaction impair Infection interact lysosomal mechanism membrane motif pathway promote Protein Proteins receptor ACE2 required RNA virus S protein SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 SNX27 Spike protein Stage Transport virion virus infection [DOI] 10.1002/mco2.92 PMC 바로가기 [Article Type] Original Article
SNPs at 3’UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studiesAPOL1 및 miR-6741-3p의 3'UTR에 있는 SNP는 SARS-COV-2 감염에 더 민감한 신장 질환과 관련된 부위를 표적으로 함: in silco 및 in vitro 연구Article Published on 2021-10-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] SARS, 변종, 치료제, [키워드] Acute kidney injury addition African American AKI angiotensin Angiotensin II APOL1 association binding binding site BRF1 calculated chemokine Chronic kidney disease CKD Collapsing control sample COVID-19 different diseases disease effective Effectiveness evaluate the effect expression first position Gene Expression genetic variants genomic sequence Genotype glomerulopathy GTF2H5 healthy HES2 identify in silico in vitro in vitro study increase increased risk Infection Interaction kidney Kidney disease Kidney diseases Kidney injury lesion Ligand likelihood MAFG Mann-Whitney U test MED12L microRNA MicroRNAs miRNA miRNAs motif NFYB nucleotide Pathways Patient Protein PRSS23 qRT-PCR relative expression reported SARS-COV-2 infection shown single-nucleotide polymorphism SLC6A19 SNP SNPs susceptibility susceptible SWT1 target target gene Target genes TLR7 TRAF3 UTR Variation with COVID-19 [DOI] 10.1007/s00335-021-09880-6 PMC 바로가기 [Article Type] Article
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas림프종의 분리 된 경우에서 SARS-COV-2에 의한 희귀 항 종양 면역 반응의 잠재적 분자 메커니즘Article Published on 2021-09-252022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, [키워드] anti-tumor immune response anti-tumor immunotherapy Apoptosis approach B-cell binding binding site Cancer CD27 CD45 cell proliferation classical Complete Complete Remission complex component domain Extracellular follicular Follicular lymphoma gamma-tubulin ring complex Hodgkin lymphoma induce inhibit initial interact interacting residues internalization Isolated lymphoma lymphoproliferative disorders M pro M protein membrane microtubule molecular mechanism monoclonal antibodies monoclonal antibody motif NF-kB nivolumab nsp10 Nsp7 oncogenesis ORF3a ORF3a protein PD-1 Pembrolizumab Potential Protein Proteins receptor Remission reported response responsible SARS-CoV-2 SARS-COV-2 infection Signaling the SARS-CoV-2 therapeutic potential TRADD TUBG1 virus [DOI] 10.3390/v13101927 PMC 바로가기 [Article Type] Article
A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding비-RBM 표적화된 RBD 특이적 항체는 S1 발산을 유도하는 SARS-CoV-2를 중화합니다Article Published on 2021-09-242022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] antibody authentic SARS-CoV-2 virus binding Cell COVID-19 COVID-19 patients Effect effective Efficacy elicited evidenced expression host cells Interaction Intervention mAb monoclonal motif neutralize Neutralizing neutralizing antibody potent promoted RBD RBD-ACE2 RBM Receptor binding domain receptor binding motif reduction S proteins S1 shedding SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viruses Syncytia syncytia formation the S protein the S1 subunit therapeutic efficacy unique virus entry [DOI] 10.1016/j.bbrc.2021.07.062 PMC 바로가기 [Article Type] Article
Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccinesCOVID-19 mRNA 백신의 면역 원성 아미노산 모티프 및 선형 에피토프Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, [키워드] Adults Amino acid approach Bacterial C-terminal domain coronavirus COVID-19 COVID-19 mRNA vaccine Critical Effectiveness elicit epitope Epitopes expressed healthy homology human coronavirus identify identity IgG Immune escape immunization immunogenic immunoprecipitate in vitro individual linear epitope linear epitopes mapped motif mRNA vaccine natural infection peptide peptides Post-vaccine primary sequence random recipients response S1 and S2 SARS-CoV SARS-CoV-2 neutralization SARS-CoV-2 spike protein Spike protein subset subunit target the SARS-CoV-2 therapy vaccination Vaccine variants were used [DOI] 10.1371/journal.pone.0252849 PMC 바로가기 [Article Type] Research Article
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formationSARS-CoV-2 Spike의 세포질 꼬리에 있는 서열은 세포 표면에서의 발현 및 합포체 형성을 촉진합니다Article Published on 2021-09-092022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] accumulate ACE2 Actin Adenovirus autophagy bind binding C-terminal Cell cell surface cellular COPI COPII cytoplasmic tail direct fusion domain Endoplasmic reticulum exit expressing expression facilitate Factor full-length S fusion Golgi histidine host cells induce Interaction lifecycle mass spectrometry motif mRNA promote Protein proteomic residue RNA vaccines SARS-CoV-2 SARS-COV-2 infection sequence sequences spike Spike protein Syncytia syncytia formation tail the cell the SARS-CoV-2 transmembrane domain understanding Vaccine vectors Vesicle Viral Virus-host interactions [DOI] 10.1038/s41467-021-25589-1 PMC 바로가기 [Article Type] Article
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro포도상구균 장독소 B 초항원에 대한 단일 클론 항체는 시험관 내에서 SARS-CoV-2 진입을 억제합니다Comment Published on 2021-09-022022-09-12 Journal: Structure (London, England : 1993) [Category] MERS, SARS, 진단, [키워드] 6D3 assays caused CDR2 Cell children common cold COVID-19 cytokine Cytokine storm explain furin furin-cleavage site furin-like cleavage site high affinity human coronavirus in vitro Infection Inflammatory inhibit Live virus mAb MIS-C monoclonal antibody motif Neutralizing Neutralizing antibodies overlap polybasic Prevent protease proteolytic activity proteolytic cleavage PRRA S1/S2 cleavage site SARS-CoV-2 entry SEB severe COVID-19 patients Spike protein staphylococcal staphylococcal enterotoxin B superantigen syndrome the cytokine storm the SARS-CoV-2 TMPRSS2 treating COVID-19 utility viral entry [DOI] 10.1016/j.str.2021.04.005 PMC 바로가기 [Article Type] Comment
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3′-5′ exoribonucleolytic activity on SARS-CoV-2약물 설계를 위한 새로운 표적: SARS-CoV-2에 대한 3'-5' 엑소리보핵분해 활성에 대한 nsp14/nsp10 복합체 형성의 중요성Article Published on 2021-09-012022-09-11 Journal: The Febs Journal [Category] SARS, 신약개발, 치료제, [키워드] activities activity Amino acid amino acids antagonist antiviral drugs assembly biochemical C-terminal catalytic complex Consequences conserved coronavirus Coronaviruses Critical DEDD disrupt domain ExoN extreme global pandemic implication in vitro in vitro activity independent independent of inhibitor inhibitors Interaction interfere interferon involved life cycle mapping molecular Molecular modeling motif MTase multifunctional protein N-terminal New nsp10 nsp14 other coronaviruses pathogenesis of SARS-CoV-2 performed Protein Replication required residue RNase SARS-CoV-2 SARS-CoV-2 virus stimulated target triggered upregulating virus [DOI] 10.1111/febs.15815 PMC 바로가기 [Article Type] Article
Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9SARS-CoV-2 비구조 단백질 9에 대한 피리미딘 RNA 염기 모방체의 결합Article Published on 2021-09-012022-09-11 Journal: The Journal of Biological Chemistry [Category] Coronavirus, SARS, 치료법, [키워드] association complex component Compound contribute Coronaviral domain engage form fragment screen homodimer induce Interaction mechanism motif Nsp9 oligomerization oligonucleotide binding probe Protein recruit replicase replicase. RNA SARS-CoV-2 SARS-CoV-2 replication seeking small molecule Stage starting point Transcription viral replication Viral RNA [DOI] 10.1016/j.jbc.2021.101018 PMC 바로가기 [Article Type] Article