Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse ModelResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adenovirus Antigen attribute binding cleavage site Combination coronavirus COVID-19 deleted exchange expresse host cell human Angiotensin-converting enzyme include induce membrane fusion Middle East Model mouse Mutation Neutralizing antibodies polybasic proline proline mutations protective effect protective immunity Protein recombinant removal respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike shown Site spike Spike protein Spike proteins tested trimer Vaccine vaccine candidate Vaccine development while wild-type [DOI] 10.1128/mBio.02648-20 PMC 바로가기 [Article Type] Research Article
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses최첨단: 마우스 SARS-CoV-2 에피토프, 감염 및 백신 유발 CD8 T 세포 반응 밝혀내Article Published on 2021-03-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] Adenovirus CD8 CD8 T cell COVID-19 COVID-19 vaccine cross-reactivity Culture Cutting dominant elicited epitope Heterologous HLA-A HLA-A*02 hospitalized patient hospitalized patients human ACE2 human disease Humoral immunity Immunity immunization intranasal magnitude memory mice mouse mucosa PBMC peptide recombinant adenovirus respiratory mucosa response responses robust SARS-CoV-2 SARS-CoV-2 nucleoprotein severity Spike protein systemically T cell T cell response T cell responses transgenic mice vaccination vaccine-elicited T cell vector viral spike protein Viral variants [DOI] 10.4049/jimmunol.2001400 PMC 바로가기 [Article Type] Article
A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variantsArticle Published on 2021-02-162023-06-08 Journal: eLife [Category] 신종인플루엔자, [키워드] Asthma host-pathogen evolution Human Influenza virus interferons mouse Mutation [DOI] 10.7554/eLife.61803 PMC 바로가기
Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A VirusArticle Published on 2021-02-032022-10-28 Journal: Viruses [Category] COVID-19, 신종인플루엔자, [키워드] acute infections addition Antiviral antiviral response ATPase block broad-spectrum common cold coronavirus coronavirus coronavirus OC43 COVID-19 vaccine derivatives disease effective Effective vaccines H1N1 Host Human immortalized include induce Infection influenza A virus Influenza virus inhibit inhibitor inhibitory innate immune Innate immunity Major mice mouse OC43 oseltamivir primary human cells Remdesivir Replication respiratory respiratory syncytial virus respiratory virus ribavirin RSV SARS-CoV-2 significantly thapsigargin treat vaccination virus [DOI] 10.3390/v13020234 PMC 바로가기 [Article Type] Article
Characterization of the low-pathogenic H7N7 avian influenza virus in Shanghai, ChinaArticle Published on 2021-02-012023-06-02 Journal: Poultry Science [Category] 조류인플루엔자, [키워드] Avian influenza virus H7N7 mouse pathogenicity phylogenetics [DOI] 10.1016/j.psj.2020.11.018 PMC 바로가기
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model마우스 모델에서 SARS-CoV-2 스파이크 단백질에 의해 유도된 사이토카인 시그니처Immunology Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Adenovirus alveolitis angiotensin Angiotensin-converting enzyme ARDS BALB/c mice BALF Bronchoalveolar lavage fluid change Clinical use colony-stimulating factor Combination contribute COVID-19 COVID-19 patient CSS cytokine Cytokine storm Cytokine storm syndrome Cytokines domain drugs effective enzyme Extracellular global health GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Health Human angiotensin-converting enzyme 2 IL-1α IL-6 IL-6 inhibitor immunostimulant indicated induced Inflammatory cytokines inhibitor inhibitors Injury interleukin interleukin 6 interleukin 6 (IL-6 investigated Jak lead lung Lung injury mAb mAbs magnetic resonance imaging mechanism Model monoclonal antibodies monoclonal antibody mortalities mouse murine model myeloperoxidase Neutralizing neutrophilic Occurrence opens phenotype polyinosinic-polycytidylic acid pro-inflammatory Protein reduced respiratory distress Respiratory distress syndrome resulting Safe SARS-CoV-2 signature spike syndrome the cytokine storm therapeutic TNF-α Tocilizumab Treatment wild-type [DOI] 10.3389/fimmu.2020.621441 PMC 바로가기 [Article Type] Immunology
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse BrainsNeurology Published on 2021-01-202022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome Affect angiotensin-converting enzyme 2 astrocytes Brain Brain infection brains Cell Central nervous system coronavirus coronavirus disease COVID-19 dataset distribution distribution analysis Effect Endothelial cell endothelial cells excitatory expressed expression host cell Human indicate inhibitory investigated middle temporal gyrus mouse mouse model neurological Neuron neurons nuclear nuclei olfactory organs pathogenic patients pericyte posterior cingulate cortex Potential SARS-coronavirus 2 SARS-CoV-2 SARS-COV-2 infection Symptom Transcriptome [DOI] 10.3389/fneur.2020.573095 PMC 바로가기 [Article Type] Neurology
Mouse Genome Database (MGD): Knowledgebase for mouse–human comparative biology마우스 게놈 데이터베이스(MGD): 마우스-인간 비교 생물학을 위한 지식 기반Comparative Study Published on 2021-01-082022-09-10 Journal: Nucleic Acids Research [Category] MERS, 변종, 유전자 메커니즘, [키워드] allele animal model Committee Community content contributed COVID-19 dataset disease Efficiency gene functions Genes Genetic Genome genomes genomic Health human disease implementation improvement Improvements Inclusion information investigators Laboratory mice mouse mouse model Mouse models nomenclature organism phenotype Phenotypes portal primary source strain Strains variants [DOI] 10.1093/nar/gkaa1083 PMC 바로가기 [Article Type] Comparative Study
Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse LungImmunology Published on 2021-01-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] ACE2 ACE2 sequence acute lung injury Analysis analyzed approaches Bayesian Body weight loss BXD family caused chromosome core Coronaviruses defined disease disease risk disease severity Dissection enzyme epithelial cells expression expression level function gene co-expression network gene product H1N1 Hierarchical Host host response identify include Infection Influenza influenza A virus lung Lung infection Lung injury MAPK membrane-bound MERS-CoV mice modulate molecular morbidity and mortality mouse mRNA level network analysis outcome parental participated potential therapeutic target primary human airway Protein pulmonary quantified respiratory diseases RNA-Seq SARS-CoV SARS-CoV-2 Sepsis severity signaling pathways significantly strain TNF transcript Transcriptome variant viral infection viral infections Viral load viremia network weight loss WGCNA [DOI] 10.3389/fimmu.2020.607314 PMC 바로가기 [Article Type] Immunology
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine면역원성이 높고 효과적인 홍역 바이러스 기반 Th1 편향 코로나19 백신530 Published on 2020-12-222022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immunity addition analyzed antibody antiviral efficacy Arm backbone candidate caused CD4 CD8 Coronavirus-2 country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective effective immunity Effective vaccines effort experiments expressing full-length S protein functional immune response genomic position gravity hamster identify IgG antibody immune immune responses Immunity immunogenic immunopathology in vivo induce insertion killing measles measles vaccine platform measles virus mice modulated mouse mouse-adapted SARS-CoV-2 multifunctional Neutralizing Patient Protective public health respiratory response S protein S protein expression Safe SARS-CoV-2 SARS-CoV-2 spike glycoprotein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significance significantly lower situation solution spike glycoprotein Spread Support T cell T cell response T cell responses Th1 immune bias the SARS-CoV-2 Threats vaccination Vaccine vaccine candidate variant virus virus load yielding [DOI] 10.1073/pnas.2014468117 PMC 바로가기 [Article Type] 530