N501Y – Page 12 – Communicable Diseases Research

Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study

뉴저지 주 의료 종사자의 백신 접종 후 SARS-COV-2: 게놈 역학 연구

Research Article

Published on 2021-11-172022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

A Novel Strategy for the Detection of SARS-CoV-2 Variants Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology

다중 PCR-질량 분석 미니시퀀싱 기술을 기반으로 하는 SARS-CoV-2 변이체 감지를 위한 새로운 전략

Research Article

Published on 2021-11-172022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] (alpha (Alpha) (Beta) Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.2 Bacteria Beta can be used can not coronavirus COVID-19 pandemic COVID-19 patient COVID-19 patients cycle threshold D614G Delta detect detection Detection limit E484K Epsilon expected extension Gamma identify Infection Iota K417N key factor L452R less mass spectrometry mPCR-MS minisequencing multiplex Multiplex PCR multiplex PCR amplification multisite mutated Mutation mutation type N501Y new SARS-CoV-2 non-COVID-19 patient Non-COVID-19 patients novel nucleic acid nucleic acid sequence open P.1 P681H P681R pathogen Pathogens PCR PCR amplification Plasmid positive sample probe provide qPCR quantitative PCR Real-time PCR Receptor-binding domain respiratory respiratory tract respiratory viruses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants screening and identification second wave selected sequence sequencing technology severe acute respiratory syndrome Coronavirus SNPs specificity Spectrometry Spike protein Spread Strategy technique technology the receptor-binding domain the spike protein time-consuming variant variants were used whole-genome sequencing
[DOI] 10.1128/Spectrum.01267-21 PMC 바로가기 [Article Type] Research Article

Organ-specific genome diversity of replication-competent SARS-CoV-2

복제 가능 SARS-CoV-2의 장기 특이적 게놈 다양성

Article

Published on 2021-11-162022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종,

[키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Asymptomatic clinical microbiology coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 treatment death died disease Evolution Evolution of SARS-CoV-2 extrapulmonary organ extrapulmonary organs fatal disease Genome heart highlighting hygiene identify Immunocompromised patient Immunocompromised patients Impact Infection information kidney lead liver lung Lungs measure multiple organ multiple organs Mutation N501Y nucleotide organ organ-specific organs Pathogenesis plasma proof provide replicate Replication replication-competent SARS-CoV-2 reported respiratory respiratory symptom respiratory symptoms Respiratory system resulting SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Single nucleotide variant spleen Stage Still systemic manifestation the patient Treatment variants variants of concern Vero E6 VERO E6 cells Viral Viral load viral loads viral pathogenesis Viremia Virological virus infectivity VOCs Y453F
[DOI] 10.1038/s41467-021-26884-7 PMC 바로가기 [Article Type] Article

A Comparative Study between Spanish and British SARS-CoV-2 Variants

스페인과 영국 SARS-CoV-2 변종 간의 비교 연구

Comparative Study

Published on 2021-11-162022-09-11
Journal: Curr Issues Mol Biol [Category] SARS, 변종,

[키워드] ACE2 ACE2 receptor Affect alignment angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenicity binding binding affinity changes in Comparative Computational docking COVID-19 deletions docking domain energy fitness genome sequence genome variant genomics characterization homology host cell identity in silico infective Interaction interfere Ligand Mutation N501Y nucleotide nucleotide substitution predicted Predictive produced Protein Proteins reason reason for receptor SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sequence sequenced similarity Spanish Spike protein stability the RBD the SARS-CoV-2 the Spike the spike protein variant virus
[DOI] 10.3390/cimb43030140 PMC 바로가기 [Article Type] Comparative Study

A Strategy to Detect Emerging Non-Delta SARS-CoV-2 Variants with a Monoclonal Antibody Specific for the N501 Spike Residue

Article

Published on 2021-11-122022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] Ag-RDT Ag-RDTs Alpha Antibody therapeutics B.1.1.7 B.1.351 B.1.617.2 categories CDC center characterized clinical diagnostic test contribute Control convalescent COVID-19 delta variant described detect diagnostic disease severity epidemiological evade help host immunity identify implication IMPROVE individual mAb monoclonal antibody mutant Mutation N501Y OCMS™ P.1 POC POC testing point-of-care populations predominant prevention PROTECT Rapid diagnostic test recognize residue sandwich ELISA SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 variant SARS-CoV-2 variants shown Specific spike Spike protein strain Strategy Surveillance the SARS-CoV-2 Transmissibility variant variants variants of concern virulence VoC VOCs
[DOI] 10.3390/diagnostics11112092 PMC 바로가기 [Article Type] Article

Molecular strategies for antibody binding and escape of SARS-CoV-2 and its mutations

SARS-COV-2의 항체 결합 및 탈출을위한 분자 전략 및 그 돌연변이

Article

Published on 2021-11-052022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

Implication of SARS-CoV-2 Immune Escape Spike Variants on Secondary and Vaccine Breakthrough Infections

2차 및 백신 돌발 감염에 대한 SARS-CoV-2 면역 탈출 스파이크 변이의 의미

Review

Published on 2021-11-032022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Breakthrough infection coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine D614G deaths disease E484K Efficacy escape etiological agent facilitate Genome Health highlight Immune escape immune evasion L452R mechanism Modification Mutation N501Y new SARS-CoV-2 promote Public health response Re-infection respiratory SARS-CoV-2 SARS-CoV-2 variants secondary Secondary infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein therapeutic Vaccine variant variants Viral viral spike protein
[DOI] 10.3389/fimmu.2021.742167 PMC 바로가기 [Article Type] Review

The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another

RT-qPCR과 관련된 SARS-CoV-2 변이체 스크리닝의 과제: 한 변이가 다른 변이를 숨길 수 있음

Article

Published on 2021-11-012022-09-11
Journal: Journal of virological methods [Category] SARS, 변종, 치료기술, 치료제,

Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2

SARS-CoV-2의 관심 대상인 새로운 B.1.621 변이체의 특성화

Article

Published on 2021-11-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘,

[키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus affecting Amino acid amino acid change amino acid changes B.1.621 binding characterization circulating coronavirus E484K emergence escape Evolution fixation Frequency genetic diversity Genome sequencing herd immunity identify Immunity insertion Lineage N-terminal domain N501Y Nanopore natural infection Neutralizing antibodies P681H processed Protein protocol rapid increase RBD Receptor binding domain required S1/S2 cleavage site SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Substitution the Spike variant Variant of interest (VOI). virus transmissibility
[DOI] 10.1016/j.meegid.2021.105038 PMC 바로가기 [Article Type] Article

Evaluation of the clinical and analytical performance of the Seegene allplex™ SARS-CoV-2 variants I assay for the detection of variants of concern (VOC) and variants of interests (VOI)

관심 변이체(VOC) 및 관심 변이체(VOI) 검출을 위한 Seegene allplex™ SARS-CoV-2 변이체 I 분석의 임상 및 분석 성능 평가

Article

Published on 2021-11-012022-09-11
Journal: Journal of Clinical Virology [Category] SARS, 변종, 치료기술,