Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
Research Article
[키워드] Cell
cell entry
Clathrin-mediated endocytosis
cleavage
conformational change
coronavirus
coronavirus
CoV
CoVs
demonstrated
endocytosed
endosomal maturation
endosomal pH
entry pathway
expressing
furin
furin cleavage site
fusion
fusion peptide
fusion protein
gene silencing
Genome
Host
host cell
host cell membrane
induce
Infection
influenza A virus
inhibited
introduced
investigated
late endosomes
less
lysosomal protease
lysosomal proteases
lysosome
membrane fusion
MERS
MERS-CoV
MHV
microenvironment
mouse hepatitis
murine hepatitis virus
negatively affected
occur
pathogen
plasma membrane
predicted
previous study
promote
protease
Protease inhibitor
Protein
proteolytic cleavage
Proteolytic processing
reporter
required
S protein
shown
siRNA
Specific
the S protein
upstream
vesicular stomatitis virus
virus
virus
while
zoonotic
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article