Mitochondrial nicotinic acetylcholine receptors: Mechanisms of functioning and biological significanceReview Published on 2022-02-012023-07-07 Journal: The international journal of biochemistry & cell biology [Category] COVID19(2023년), [키워드] Mitochondria Neuroinflammation Nicotinic acetylcholine receptor SARS-CoV-2 [DOI] 10.1016/j.biocel.2021.106138 [Article Type] Review
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article
Meta-Analysis of APP Expression Modulated by SARS-CoV-2 Infection via the ACE2 ReceptorArticle Published on 2022-01-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome affected Alzheimer’s disease Alzheimer’s disease amyloid-beta precursor protein angiotensin-converting enzyme-2 app binding canonical caused characterized cleavage conducted core coronavirus Coronavirus-2019 COVID-19 downregulated exacerbating expression Infection Inflammation Ingenuity Pathway Analysis investigated involved IPA less Meta-analysis modulation Neuroinflammation P -value pathway plaque precursor progression Protein receptor resulting SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 signaling pathway upregulated upregulation upstream virus Z-score [DOI] 10.3390/ijms23031182 PMC 바로가기 [Article Type] Article
Penetration of the SARS-CoV-2 Spike Protein across the Blood–Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical BiosensingArticle Published on 2022-01-172022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] barrier biosensor Brain Caco-2 cells caused cell layer circulation consequence coronavirus spike protein cross demonstrated disseminate ELISAs Endothelial cell evaluate global pandemic Human human brain endothelial cell in vitro Infection Integrated optics intestinal investigated Mach–Zehnder interferometer mechanism mice Model model system Neuroinflammation Neuroinvasive Neurological symptom observation optical organ outbreak penetration permeability Respiratory Coronavirus Respiratory system Revealed route of infection SARS-CoV-2 spike Spike protein System the disease the S1 subunit the SARS-CoV-2 tissue barriers viral spike protein [DOI] 10.3390/biomedicines10010188 PMC 바로가기 [Article Type] Article
The Impact of Systemic Inflammation on Alzheimer’s Disease PathologyReview Published on 2022-01-062024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Alzheimer’s disease Gut-brain axis Neuroinflammation peripheral inflammation systemic inflammation [DOI] 10.3389/fimmu.2021.796867 PMC 바로가기 [Article Type] Review
Prospective, observational, single-centre cohort study with an independent control group matched for age and sex aimed at investigating the significance of cholinergic activity in patients with schizophrenia: study protocol of the CLASH-studyArticle Published on 2021-12-202022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] acetylcholinesterase addition adult psychiatry age and sex alteration anticipated approach approval association Butyrylcholinesterase calculated carried changes clinical clinical conditions clinical symptom code cognitive cognitive disorders cohort study control group Critically ill patient delirium delirium & Department disorders duration of illness enrolment esterase Ethics Evidence extension form Germany Hospital admission Hypothesis independent metabolism negative Neuroinflammation Observational cohort study parameter pathophysiological Patient point-of-care Prospective psychotherapy psychotic disorders. Registered required Sample size SARS-CoV-2 pandemic scale Schizophrenia schizophrenia & schizophrenic Secondary objective statistical analysis Study protocol Symptom the ethics committee Ulm university [DOI] 10.1136/bmjopen-2021-050501 PMC 바로가기 [Article Type] Article
CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelinationResearch Article Published on 2021-12-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Activation Autoimmune CD4 CD40 CD40L Cell chronic infection CNS comparable Demyelination disease etiology Evidence exhibited expression hallmark Immunosuppression Immunosuppressive treatment indicate induce Infection infiltration Inflammatory Interaction investigated mechanism mice Migration modulated molecular mouse hepatitis mouse hepatitis virus Multiple Neuroinflammation Neurological disease pathogenic patients phagocytic poliomyelitis proceed Prophylaxis PROTECT Protective protective role recent recruitment reduced Result shown significantly susceptible T cell [DOI] 10.1371/journal.ppat.1010059 PMC 바로가기 [Article Type] Research Article
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 InfectionSARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘, [키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score [DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis
Dynamic Changes in Central and Peripheral Neuro-Injury vs. Neuroprotective Serum Markers in COVID-19 Are Modulated by Different Types of Anti-Viral Treatments but Do Not Affect the Incidence of Late and Early StrokesArticle Published on 2021-11-292022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 105 patient acute phase Admission Affect amyloid baseline level CCL23 change changes in Cluster clusterin collected conditions convalescent plasma correlated COVID-19 CRP D-dimer declined demonstrated diagnosis of COVID-19 dynamic elevated Elevation fetuin heterogeneity Hospitalized IL-6 incidence Inflammatory response initial KLK6 lack leukopenia marker MCP-1 MIF neurodegeneration neurodegenerative Neuroinflammation neurological nonspecific opposite outcomes Patient peripheral Platelet Proteins Registered remained Remdesivir response serum Serum level Serum Marker significantly Spike protein Steroids stroke therapy Treatment Type variable viral burden was increased YKL-40 [DOI] 10.3390/biomedicines9121791 PMC 바로가기 [Article Type] Article
Systemic Inflammation and Astrocyte Reactivity in the Neuropsychiatric Sequelae of COVID-19: Focus on Autism Spectrum DisordersCellular Neuroscience Published on 2021-11-292022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Astrocyte astrocytes astrogliosis autism Autism spectrum disorders COVID-19 focus microglia Neuroinflammation reactive gliosis SARS-CoV-2 Spectrum systemic [DOI] 10.3389/fncel.2021.748136 PMC 바로가기 [Article Type] Cellular Neuroscience