Basal Ganglia Involvement and Altered Mental Status: A Unique Neurological Manifestation of Coronavirus Disease 2019Neurology Published on 2020-04-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Altered altered mental state Altered mental status approach basal ganglia Brain Case report Central nervous system Clinical characteristics CNS complication of COVID-19 consequence coronavirus coronavirus disease Coronavirus infection COVID-19 described diagnostic evaluate ganglia help hematogenous hemorrhage IMPROVE incidence Infection Involvement Like management manifestation Neurological complication neuronal pathway Patient presenting recognize reported SARS-CoV-2 SARS-COV-2 infection Symptom Treatment unique virus [DOI] 10.7759/cureus.7869 PMC 바로가기 [Article Type] Neurology
Complexin in ivermectin resistance in body lice몸니의 이버멕틴 저항성에 있는 콤플렉스Research Article Published on 2018-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis animals association cDNA changes complexin correlation differentially expressed downregulated Effect evaluated Evidence expression helminthic disease helminthic diseases Human induce insecticide Interference involved Ivermectin knocking down Laboratory loci mechanism mRNA Mutation mutations neuronal nonsense mutation other infestations pediculicide premature stop codon Protein protein level Proteins proteome proteomic Proteomic analysis qRT-PCR regulated reported searched shown significantly susceptible transcript transcriptional unique upregulated Variation [DOI] 10.1371/journal.pgen.1007569 PMC 바로가기 [Article Type] Research Article
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1Microbiology Published on 2017-05-032022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] cause caused Central nervous system CNS Control cortical demonstrated dendritic disease disrupting dysfunction Encephalomyelitis functional Host increased survival Infection inhibitor Injury mice microenvironment microRNA miR-142-5p morphogenesis mRNA neurodegeneration neurodegenerative neurological Neuron neuronal neuronal morphogenesis neurotropic virus PHE phenotype porcine hemagglutinating encephalomyelitis virus provided regulate Relieving significantly spatiotemporal targeting Ulk1 viral replication virus [DOI] 10.3389/fcimb.2017.00155 PMC 바로가기 [Article Type] Microbiology
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSRetrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다Research Article Published on 2017-03-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase [DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article