Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 TreatmentReview Article Published on 2020-07-162022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation Affect autophagy build caused clinical picture COVID-19 damage-associated molecular pattern damaged DAMPs excessive inflammatory response HMGB1 immune response increase in induce Inflammation Innate immunity lung cell NETosis NETs neutrophil Neutrophil extracellular trap new coronavirus SARS-CoV-2 pandemic disease pattern Potential released Respiratory system robust SARS-COV-2 infection sustained target targeted therapy the disease Treatment viruses [DOI] 10.1155/2020/7527953 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosisResearch Published on 2020-07-142022-10-28 Journal: Respiratory Research [Category] COVID-19, SARS, [키워드] ACE2 activate acute lung injury acute respiratory syndrome ADAM17 Affect AGT angiotensin-converting enzyme 2 assist bind binding bioinformatic analysis cellular receptor change cleaved connective tissue coronavirus COVID-19 CTGF dataset disease domain driver endothelial enzyme epithelial cell FN1 growth factor host cells human epithelial cell human lung induce Lung epithelial cells Lung fibrosis lung tissue mechanism metalloproteinase mRNA pandemic disease patients promote Protein protein expression Result SARS-CoV-2 SARS-COV-2 infection specific treatment TGFB1 Tissue Inhibitor TMPRSS2 transcriptional transmembrane serine protease Vascular VEGF viral entry were expressed were measured [DOI] 10.1186/s12931-020-01445-6 PMC 바로가기 [Article Type] Research
Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitisCase Report Published on 2020-07-022022-10-29 Journal: World Journal of Emergency Surgery : WJES [Category] COVID-19, SARS, [키워드] abdominal pain addition adherent Administered Affect affected anti-CD4 appear blood tests characterized Cholecystitis cholestasis clinical condition clinical conditions complication of COVID-19 condition coronavirus COVID-19 COVID-19 patient CT scan develop Diagnosis dysregulated endothelial enoxaparin Evolution form Gallbladder Hemorrhagic histological Histopathology host inflammatory response Hydroxychloroquine ICU ICU admission immunohistochemistry Infarction Infection infiltration Inflammatory intensive care Invasive mechanical ventilation Ischemic liver local tissue inflammation lung lymphocyte Macrophage male mucosa Novel coronavirus omentum organ overexpression pandemic disease Patient Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment severity subcutaneously surgeon T helper the disease thrombosis Vasculitis vessel vessels was performed worsened [DOI] 10.1186/s13017-020-00320-5 PMC 바로가기 [Article Type] Case Report
A 95-year-old patient with unexpected coronavirus disease 2019 masked by aspiration pneumonia: a case reportCase Report Published on 2020-06-232022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected aspiration pneumonia Case report Chest China clinical history Complication Computed tomography Contact coronavirus disease Coronavirus-2 COVID-19 defined Dementia develop diagnosing Diagnosis diagnostic Dysphagia elderly epidemiological link expected feature greater Health highest highlight hospitals individual Infection infectious risk initial Italy mortality rates multiple comorbidities Older older adult pandemic disease Patient patients with comorbidity Pneumonia professional reduced SARS-CoV-2 Spread susceptible Vascular [DOI] 10.1186/s13256-020-02432-7 PMC 바로가기 [Article Type] Case Report
Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial CellsArticle Published on 2020-06-192022-10-28 Journal: Plants [Category] COVID-19, [키워드] ACE2 ACE2 blocker ACE2 expression Acetate acute respiratory syndrome addition Analysis angiotensin-converting enzyme 2 Anti-viral anti-viral agent Cell citronellol Compound contribute coronavirus COVID-19 downregulated epithelial cells Essential evaluated Gas Chromatography-Mass Spectrometry Geranium geranium essential oil health emergency host cell receptor inhibitory effect Inhibitory effects Intervention Invasion lemon lemon essential oil lemon oil limonene Oil pandemic disease qPCR analysis receptor SARS-CoV-2 significantly spike TMPRSS2 Treatment virus [DOI] 10.3390/plants9060770 PMC 바로가기 [Article Type] Article
Evaluation of health-related quality of life using EQ-5D in China during the COVID-19 pandemicResearch Article Published on 2020-06-182022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus acute respiratory syndrome Affect analyzed can be used categorical data China chronic disease coronavirus country COVID-19 COVID-19 epidemic COVID-19 pandemic dimensions disease Effects Epidemic EQ-5D Evidence Factor FIVE General population Health Health status healthcare measure media mental health objective pandemic disease participant physical provide Quality of life questionnaire raised recruited regions Regression model reported Result risk SARS-CoV-2 significantly suffered were used Wuhan [DOI] 10.1371/journal.pone.0234850 PMC 바로가기 [Article Type] Research Article
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor FedratinibShort communication Published on 2020-06-012022-10-05 Journal: Journal of microbiology, immunology, and infection [Category] SARS, 유전자 메커니즘, [키워드] approved COVID-19 Cytokine storm development effective FDA Fedratinib high mortality immune inhibitor JAK2 JAK2 inhibitor pandemic disease Patient patients with SARS-CoV-2 profiles reducing mortality response SARS-CoV-2 Th17 Treatment [DOI] 10.1016/j.jmii.2020.03.005 [Article Type] Short communication
Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19Research Perspective Published on 2020-05-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] aging Air pollution cascade cause caused COVID-19 cytokine IL-6 Infection infection rates Inflamm-aging Inflammation Inflammatory Inflammatory cytokine lung metformin mitochondrial molecular morbidity and mortality novel coronavirus SARS-CoV-2 Older outcome overlap pandemic disease Particulate matter pathological Population Prevent proinflammatory prothrombotic risk SARS-COV-2 infection severe COVID-19 severity Signaling therapeutic therapeutic strategy thrombotic Transport Trigger [DOI] 10.18632/aging.103347 PMC 바로가기 [Article Type] Research Perspective
Unanswered questions about the Middle East respiratory syndrome coronavirus (MERS-CoV)Short Report Published on 2014-06-112022-10-27 Journal: BMC Research Notes [Category] Coronavirus, [키워드] Arabian Peninsula arising Combination Contact CoV Emerging infectious disease Epidemic Epidemics Epidemiology explain feature finding highlight hospital Human include Infection many case MERS MERS-CoV Middle East outbreak Outbreaks pandemic disease proportion question reported reproductive respiratory syndrome coronavirus Saudi Arabia source of infection sustained Transmission virus [DOI] 10.1186/1756-0500-7-358 PMC 바로가기 [Article Type] Short Report