SARS‐CoV‐2 spike glycoprotein‐reactive T cells can be readily expanded from COVID‐19 vaccinated donorsSARS-CoV-2 스파이크 당단백질 반응성 T 세포는 COVID-19 백신 접종 기증자로부터 쉽게 확장될 수 있습니다Original Article Published on 2021-07-272022-09-12 Journal: Immunity, Inflammation and Disease [Category] SARS, 진단, [키워드] BNT162b2 CD4 CD8 Cell Cell culture cellular cellular immunity Chemotherapy Combination Comorbidity coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 vaccination Donor donors dose Efficacy ENhance evaluated Ex vivo ex vivo expansion generate healthy humoral Humoral immunity Humoral response immunodeficiency Immunotherapy Infection investigated mononuclear cell mRNA Patient PBMC PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells powerful tool proportion proportions protective role protocol rapid expansion reactive REP Respiratory Coronavirus Result SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 spike glycoprotein spike glycoprotein‐reactive suppressed T cell T cells tested the vaccine vaccination Vaccine [DOI] 10.1002/iid3.496 PMC 바로가기 [Article Type] Original Article
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display librariesArticle Published on 2021-07-272022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] 2B11 ACE2-binding site acute respiratory syndrome antibodies antibody B.1.1.7 B.1.1.7 variant B.1.351 Combination complexes convalescent coronavirus COVID-19 convalescent patients effective intervention Efficacy Efficiency eight epitope Epitopes exhibited experiment Genes heavy chain highest affinity IGHV immune Immunoglobulin immunology in vivo mice NAb neutralization neutralization potency Neutralizing neutralizing antibody overlap P.1 PBMC Prophylactic pseudoviruses public health RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2-neutralizing antibody Screening structural biology the receptor-binding domain the S1 protein therapeutic Treatment variant viruses wild-type WT SARS-CoV-2 [DOI] 10.1038/s41421-021-00295-w PMC 바로가기 [Article Type] Article
Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by α-1 Antitrypsin †Article Published on 2021-07-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] AAT Activation activity Anti-inflammatory anti-inflammatory activity antitrypsin chemokines Combination conditions COVID-19 COVID-19 infection cytokine production Cytokines demonstrated Effects ENhance Ex vivo expressed facilitate forms host protease Human human PBMC hyper-inflammation IL-1β IL-6 IL-8 immunomodulatory activities in vitro in vivo Inflammation inhibit inhibited Interaction lipopolysaccharide LPS mononuclear cell mRNA expression oxidized Patient PBMC PBMCs Peripheral blood pro-inflammatory pro-inflammatory response Protein purified reduced SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 significantly spike Spike protein statistical significance therapy TNF-α Treatment Trimeric spike protein viral entry [DOI] 10.3390/ijms22157941 PMC 바로가기 [Article Type] Article
Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In VivoArticle Published on 2021-07-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 activity acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding blockade blocked clinical outcomes commensal bacteria coronavirus correlated COVID-19 cytokine cytokine expression cytokine production endotoxin exhibited host cell immune responses Impact in vitro induce inducer induction Infection inflammatory cytokine production inhibited inhibitor Interaction Like LPS mechanism MERS Middle East modeling mononuclear cell mucosal tissue Neutralizing pathogenic pathway PBMC Peripheral blood Potential Proinflammatory cytokine promote reagent reagents reported respiratory SARS CoV-2 soluble ACE2 spike Spike protein variable [DOI] 10.3390/ijms22147540 PMC 바로가기 [Article Type] Article
The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019Carcinoembryonic 항원의 예측 역할과 코로나 바이러스 질병의 진행에서의 기본 메커니즘 2019Research Published on 2021-07-032022-08-31 Journal: Critical Care [Category] SARS, 바이오마커, [키워드] adult COVID-19 patient Analysis Antigen BALF Biomarker Carcinoembryonic antigen Carcinoembryonic antigen-related cell adhesion molecules CEA CEACAM6 CEACAM8 conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Developing neutrophils downloaded epidemiological Hospitalized identify Laboratory lung Lungs mechanism Mortality Multivariate analysis neutrophil Neutrophils objective overall survival PBMC PBMCs potential mechanism predict predictor prognostic prognostic indicator Prognostic value progression Result Retrospective study scRNA-seq data significant difference significantly supplementary material survival Type II pneumocyte type II pneumocytes Wuhan [DOI] 10.1186/s13054-021-03661-y PMC 바로가기 [Article Type] Research
Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증급성호흡기증후군 코로나바이러스 2 감염 후 최대 8개월까지 질병의 중증도에 따른 인간 기억 T 세포 반응의 종단 분석Article Published on 2021-07-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료법, [키워드] 8 months acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen Asymptomatic Asymptomatic disease CD4+ T cell CD4+ T-cell coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cytometry analysis Flow cytometry analysis Frequency greater healthy volunteer healthy volunteers Human illness Longevity longitudinal membrane membrane protein memory memory response memory T-cell response Mild Mild disease mononuclear cell mononuclear cells Month nucleocapsid Patient patients with COVID-19 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells persist post-symptom onset protective effect protective immunity PSO Reinfection respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe disease severity severity of illness T cell T cells T-cell T-cell Response T-cell responses understanding vaccination with mild disease [DOI] 10.1093/infdis/jiab159 PMC 바로가기 [Article Type] Article
HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis만성 B형 간염에 대한 치료 백신인 HeberNasvac은 선천 면역의 국소 및 전신 표지자를 자극합니다: SARS-CoV-2 노출 후 예방에 잠재적 사용Article Published on 2021-07-012022-09-11 Journal: Euroasian J Hepatogastroenterol [Category] 비임상, [키워드] Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral properties antiviral property both sexes breath CHB chronic chronic hepatitis Chronic Hepatitis B clinical trial Cohort coronavirus coronavirus disease COVID-19 Dengue died Disease progression dose enrolled evidenced expression functional Hepatocellular carcinoma immune cells Immunity immunomodulating immunomodulatory immunomodulatory effect impairment increased expression Innate innate immune cell Innate immune cells Innate immunity intranasal lethal infection Local Lymphocytes malignancies malignancy marker material mice monocyte Monocytes mononuclear cell nasopharyngeal Older Open-label pandemic Patient patients PBMC Peripheral blood periphery Postexposure Postexposure Prophylaxis Potential presenting prophylactic therapy Prophylaxis randomized clinical trial reduction in respiratory infections Result Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown subjects surrogate markers Symptom symptoms of COVID-19 systemic the patient therapeutic therapy Toll-like receptor Toll-like receptors tonsils Treatment Vaccine [DOI] 10.5005/jp-journals-10018-1344 PMC 바로가기 [Article Type] Article
Self-prescribed Ivermectin use is associated with a lower rate of seroconversion in health care workers diagnosed with COVID, in a dose-dependent response자가 처방 Ivermectin 사용은 용량 의존적 반응에서 COVID로 진단된 의료 종사자의 낮은 혈청 전환율과 관련이 있습니다Article Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 진단, 치료기술, [키워드] abdominal pain age antibody Brazil Clinical efficacy Cohort consequence COVID COVID-19 cross-sectional cross-sectional study cytokine Cytokines diagnosed diagnosed with COVID-19 diarrhea disease severity dose dose-dependent drug Effectiveness evaluate the effect evaluated Evidence groups HCW Health care Health care worker health care workers immune response immunomodulatory effects Impact impairment in vitro increasingly Ivermectin lack less mechanism mononuclear cell mononuclear cells multiple dose multiple doses Neutralizing antibodies neutralizing antibody Pain participant Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells Professor purified rate of seroconversion Reinfection reported risk SARS-CoV-2 SARS-CoV-2 treatment Seroconversion Side-effect Spike protein stimulated stratified Treatment treatment of COVID-19 women [DOI] 10.1016/j.bjid.2021.101603 PMC 바로가기 [Article Type] Article
H-Ras gene takes part to the host immune response to COVID-19Perspective Published on 2021-06-252022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] affected Cancer Comparative analysis condition COVID-19 COVID-19 patient COVID-19 patients downregulated expression Gene Expression Gene expression analysis Host immune response independent datasets mononuclear cell mutated Patient PBMC performed Peripheral blood Predictive markers SARS-COV-2 infection SARS-CoV-2 virus infection severe disease significantly upregulated upregulation viral infection was performed [DOI] 10.1038/s41420-021-00541-w PMC 바로가기 [Article Type] Perspective
Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine SeroconversionArticle Published on 2021-06-252022-10-31 Journal: Genes [Category] COVID-19, [키워드] 95% CI applied approach AUC B cell B lymphocyte B lymphocytes Biomarker blood transcriptome Cell clinical setting collected correlated COVID-19 COVID-19 vaccines datasets determine develop Direct expressed expression FCRLA Gene Expression gene expression dataset Genes greater immunology Influenza leukocyte log measurement mononuclear cells pathway PBMC peripheral Peripheral blood Precision predict predicted prediction Predictive proportion purified reference gene Responder sensitivity Seroconversion SMD subpopulation subpopulations target gene TNFRSF13C TNFRSF17 transcript transcript abundance Transcriptome Trial TXNDC5 vaccination was used [DOI] 10.3390/genes12070971 PMC 바로가기 [Article Type] Article