Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural researchArticle Published on 2021-03-232022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Agricultural genetics animal annotation Community Comparative analysis complex conserved Critical dataset DNA driver eight element epigenomics functional Gene regulation genetics Genome genomes independent information non-coding variants phenotypic predicted regulatory element Research resource resources target gene tissue traits transcription factor unique Variation [DOI] 10.1038/s41467-021-22100-8 PMC 바로가기 [Article Type] Article
Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 PandemicGenetics Published on 2021-03-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Alter alteration assist association chromatin coronavirus Coronaviruses COVID COVID-19 deaths develop DNA Epidemics Epigenetic epigenetic modulation epigenetics evade Factor Genetic global infection highlight Host host cell host gene expression Host immune response host-pathogen interaction human populations immune response immune sensing Immunopathogenesis Infection interactions interfere intrinsic involved kill knowledge Len mechanism MERS-CoV Methylation miRNA Modification modulate modulated Mortality Non-coding RNAs pandemic Pathogenesis pathway phenotypic prevent disease progression provide regulate Replication researchers respiratory respiratory RNA viruses RNA virus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARSCoV2 SARSCoV2 pathogenesis Spread the disease treat Treatment Variation virus widespread [DOI] 10.3389/fgene.2021.581726 PMC 바로가기 [Article Type] Genetics
Treatment Protocol for COVID-19 Based on T2R PhenotypeArticle Published on 2021-03-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Assessing association average bitter taste bitter taste receptors coronavirus correlation COVID-19 COVID-19 patient Dexamethasone diagnosed duration of symptom expression global pandemic highest Hospitalization Hydroxychloroquine Multiple outcome Patient PCR phenotype phenotypic receptor required Retrospective study SARS-CoV-2 severity of COVID-19 solitary chemosensory cells starting subject T2R38 tested Treatment protocol were given [DOI] 10.3390/v13030503 PMC 바로가기 [Article Type] Article
Persistent Bacterial Coinfection of a COVID-19 Patient Caused by a Genetically Adapted Pseudomonas aeruginosa Chronic Colonizer유전적으로 적응된 녹농균(Pseudomonas aeruginosa) 만성 집락자에 의한 COVID-19 환자의 지속적인 세균 동시 감염Cellular and Infection Microbiology Published on 2021-03-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adapted adenine alginate Analysis Antibiotic resistance Bacteria biofilm cause chronic chronic infection chronic infections Coinfection collected component COVID-19 COVID-19 patient COVID-19 patients demonstrated differential gene expression analysis displaying DNA DNA methylation ENhance Epigenetic Exacerbation Extracellular matrix flagellar Gene expression analysis Genes genomic high mortality rate hospital Immunocompromised Immunocompromised patient Immunocompromised patients in vivo indicated isolate leads marker Methylation morphology opportunistic pathogen overproducing P. aeruginosa pathogen Patient performed persistent phenotypic predicted Pseudomonas aeruginosa quorum reducing SARS-CoV-2 Sequencing severe COVID-19 transcriptional regulation transcriptomic variant virulence [DOI] 10.3389/fcimb.2021.641920 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Adaptive immunity to human coronaviruses is widespread but low in magnitudeOriginal Article Published on 2021-03-172022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] Adaptive immunity Adults anatomical antibody Antibody Response Antigen Blood Ccr6 CD4 T cell CD4 T cells CD4 T‐cell Cell cellular central memory Chemokine receptor childhood circulating circulation component coronavirus coronavirus immunity correlated Critical cTFH CXCR3 Endemic exhibited expression follicular Frequency HCoV HCoVs HKU1 homeostatic human coronavirus humoral IgG immune response include individuals Lymph node lymph nodes magnitude marker memory memory T cell Mortality objective participant phenotype phenotypic provide quantified response responses Result SARS‐CoV‐2 SARS‐CoV‐2 Seroconversion T cell T‐cell T‐cell response titres widespread [DOI] 10.1002/cti2.1264 PMC 바로가기 [Article Type] Original Article
Structural and Drug Screening Analysis of the Non-structural Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Virus Extracted From Indian Coronavirus Disease 2019 PatientsGenetics Published on 2021-03-092022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] absence acute respiratory syndrome affected Analysis Antiviral China city coronavirus coronavirus 2 coronavirus disease country COVID-19 database deaths drug Drug screening effective Extracted Frequency Genetic variant genomic homology human protein imperative in silico India infecting information lockdown molecular Mutation non-structural proteins novel Novel coronavirus outbreak outcome pandemic Patient Perspective phenotypic Phylogenetic profiles Protein protein complexes provided Region Repository respiratory resulting SARS-CoV2 Screening selected Spread stability survival took place Vaccine variant variants Variation virulence virus wild-type Wuhan [DOI] 10.3389/fgene.2021.626642 PMC 바로가기 [Article Type] Genetics
Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional StudyProtocol Published on 2021-03-042022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] “COVID-19 African alleles amplification analyses Analysis Apoptosis apoptotic pathways association Bax BCL-2 BCL2L12 Biomarker carried caspase 3 categories caused CD4 collected Comorbidity complete blood count Concentration country COVID-19 COVID-19 complication COVID-19 pandemic cross-sectional Cytokine storm determinant determine Disease progression distribution DNA EDTA ELISA enrolled enzyme-linked immunosorbent expected expression expression level flow cytometry Frequency genetic determinants Genomic DNA genotyped genotypes genotypic genotyping Haplotype Hardy-Weinberg equilibrium Health health system help Hospitalized hospitalized patient Hypovitaminosis D Identifier Immunopathogenesis IMPROVE Improving include individual infected patients infected with SARS-CoV-2 information Lagos Linkage disequilibrium Lymphocyte count lymphopenia MONITOR Nigeria objective Other outcome participant Participants Patient PCR performed phenotypic polymerase chain polymorphism Prevalence Prognosis questionnaire R statistical software report Repurposed drug Result reverse transcribed reverse transcription PCR risk stratification RNA RNA sample RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–positive Sequencing serum sample serum vitamin D severe infections soluble Fas ligand Stratification study outcome T cell assay T lymphocyte Total Travel Treatment treatment regimen understanding vascular cell adhesion VDR venous blood Vitamin D receptor Vitamin D status with COVID-19 [DOI] 10.2196/21242 PMC 바로가기 [Article Type] Protocol
Extreme phenotypes approach to investigate host genetics and COVID-19 outcomesArticles Published on 2021-03-012022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] approach asymptomatic individual candidate gene Clinical outcome Comorbidities COVID-19 COVID-19 severity Deceased event Evidence extreme extreme phenotypes genomic study heterogeneous host genetics Immunity Infection Infectious disease Inflammation intrinsic involved outcome outcomes Pathways phenotype phenotypic risk factor SARS-COV-2 infection subject’ [DOI] 10.1590/1678-4685-GMB-2020-0302 PMC 바로가기 [Article Type] Articles
Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO studyObservational Study Published on 2021-03-012022-10-05 Journal: Diabetes & metabolism [Category] SARS, 임상, [키워드] Admission analyses Analysis approach association cardiovascular disease Characteristics COVID-19 COVID-19 related mortality death Diabetes Mellitus French high-risk population hospital increased mortality Inpatient Interaction intubation Logistic regression analysis Mortality mortality rate outcome outcomes Patient patients hospitalized patients with COVID-19 phenotypic Primary outcome Probability Prognosis recent reported Result routine severe coronavirus disease significantly significantly higher statins tracheal Treatment Type type 2 diabete Type 2 diabetes mellitus Weighting women [DOI] 10.1016/j.diabet.2020.10.001 PMC 바로가기 [Article Type] Observational Study
Phenotypes and Subphenotypes of Patients With COVID-19: A Latent Class Modeling AnalysisResearch article Published on 2021-02-262022-10-05 Journal: Chest [Category] 바이오마커, [키워드] Analysis analyzed assist association Basic science Biomarker Blood class Cleveland clinic Clinical outcome clinical trial clinical trials Cluster Comorbidities Concordance COVID-19 COVID-19 phenotype COVID-19 symptom database death demographics elevated evaluated help heterogeneity hospital Hospital admission Hospitalization hospitalized patient hospitalized patients Hyperinflammatory ICU identifying independent investigated investigator kidney dysfunction laboratory-confirmed SARS-CoV-2 infection Latent latent class latent class analysis lymphopenic modeling Mortality Patient patients patients with COVID-19 phenotype Phenotypes phenotypic Platelet positive predict presenting presenting symptoms profile Research researcher Result significantly stratified subphenotypes Symptoms System transfer translational WBC [DOI] 10.1016/j.chest.2021.01.057 [Article Type] Research article