plasma sample – Page 12 – Communicable Diseases Research

High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease

SARS-CoV-2 RNA혈증의 높은 빈도 및 중증 질환과의 연관성

Article

Published on 2021-05-042022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술,

Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease

Clinical Trial

Published on 2021-04-292022-10-04
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상,

Disparities of SARS-CoV-2 Nucleoprotein-Specific IgG in Healthcare Workers in East London, UK

Medicine

Published on 2021-04-272022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Abbott anti-Nucleocapsid IgG antibody Antibody detection Architect Asian black category central London Concordance conducted COVID-19 COVID-19 symptom declining demonstrated determine diagnostic disparity East Effects enrolled enrolment Ethnicity evaluate evaluated Follow-up greater HCW healthcare healthcare worker Healthcare workers hospital hypertension IgG independent predictor Laboratory tests London marker MONITOR NHS Older age participant Participants persistence plasma sample point-of-care positive Prevalence Rapid test Reinfection representing retained risk factor Risk factors SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-COV-2 infection Sero-surveillance seroconverted severe COVID-19 illness spread of COVID-19 Trust worker
[DOI] 10.3389/fmed.2021.642723 PMC 바로가기 [Article Type] Medicine

Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma

회복기 혈장 내 다작용성 SARS-CoV-2 항체 마커

Research Article

Published on 2021-04-202022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

[키워드] Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC addition analyzed antibody Antibody Response antibody-dependent cellular cytotoxicity Antiviral antiviral activity Antiviral effect Better binding blood donor Blood donors Cell Characteristics complement Complement activation contribute convalescent convalescent individual convalescent plasma convalescent plasma samples coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Diversity Donor Efficacy eligible evaluate evaluated exhibited expand Features fraction function functional functional antibody response functions high accuracy Humoral response humoral responses IgA IgG individuals Intervention Mutation neutralization neutralizing capacity offer phagocytosis plasma plasma sample plasma samples reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapy treatment for COVID-19 validation cohort variant Viral viral neutralization
[DOI] 10.1128/mBio.00765-21 PMC 바로가기 [Article Type] Research Article

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

다중 플랫폼 omics 분석은 COVID-19 발병기전, 예후 및 약물 표적 발견을 위한 분자 서명을 보여줍니다

Article

Published on 2021-04-152022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 임상, 치료기술, 치료제,

Distinct SARS-CoV-2 antibody reactivity patterns in coronavirus convalescent plasma revealed by a coronavirus antigen microarray

코로나바이러스 항원 마이크로어레이로 밝혀진 코로나바이러스 회복기 혈장의 뚜렷한 SARS-CoV-2 항체 반응성 패턴

Article

Published on 2021-04-062022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 진단,

[키워드] acute COVID-19 Adaptive immunity administration analyses Analysis analyzed antibody reactivity Antibody Response Antibody responses Antigen antigens array assays CCP chemiluminescence immunoassay clinical Clinical studies Cluster Clustering analysis collected Computational approaches Concordance convalescent plasma coronavirus COVID-19 case COVID-19 cases COVID-19 convalescent plasma Cutoff disease Donor Emergency use EUA FDA Generalized linear model Hierarchical Hierarchical clustering analysis Humoral immunity identify immunoassay Immunoglobulin IMPROVE Infection intensity MERS Microarray multiplex neutralization Neutralization assay offer plasma plasma sample plasma samples positive Predictive pseudovirus random Random forest reactive reactivity reactivity pattern recombinant proteins reporter Result SARS-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV2 serum specimen the SARS-CoV-2 therapeutic efficacy threshold thresholds Total total Ig training set Treatment vaccination vaccine immunogenicity Viral viral particle was used with COVID-19
[DOI] 10.1038/s41598-021-87137-7 PMC 바로가기 [Article Type] Article

Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study

인간 코로나바이러스 OC43 스파이크 단백질에 대한 교차 반응성 항체는 COVID-19 환자의 질병 중증도와 상관관계가 있습니다: 후향적 연구

Research Article

Published on 2021-04-022022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술,

[키워드] age antibody Antibody titre antigenic change collected correlated correlation correlations COVID-19 COVID-19 pathogenesis COVID-19 patients cross-reactive antibody cross-reactivity detectable disease severity evaluated HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoV-OC43 spike HCoVs healthy control healthy controls HKU1 human coronavirus human coronavirus OC43 human populations humoral Humoral response IgG IgG antibody mechanical ventilation mild patient mild patients mounted Neutralizing antibodies NL63 OC43 Pathogenesis Patient plasma sample plasma samples positive Protein PSO Retrospective study S protein SARS-CoV-2 seasonal severe disease severity significant increase significantly higher Spike protein Spike proteins Spread symptom onset tested the disease titre
[DOI] 10.1080/22221751.2021.1905488 PMC 바로가기 [Article Type] Research Article

Increased Prevalence of Myocardial Injury in Patients with SARS-CoV-2 Viremia

SARS-CoV-2 바이러스혈증 환자의 심근 손상 유병률 증가

Article

Published on 2021-04-012022-09-11
Journal: The American journal of medicine [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition baseline characteristics cardiac cardiac injury cardiac troponin Characteristics clinically complex interplay coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cTnT detectable female Hospitalization hospitalized patient hospitalized patients Increased Injury median age medical record Mortality myocardial injury Older outcome outcomes pathway Patient patients hospitalized patients with COVID-19 plasma plasma sample plasma samples Prevalence SARS-CoV-2 SARS-CoV-2 viral load significantly significantly higher subset the patient troponin troponin T unique Viral load viral loads Viremia was measured with COVID-19
[DOI] 10.1016/j.amjmed.2020.09.046 PMC 바로가기 [Article Type] Article

Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections

Physiology

Published on 2021-04-012022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] addition alveolar ameliorated ARDS Biomarker blood chemistry burn patient chemical mediator contributing to COVID-19 COVID-19 disease COVID-19 patients Degradation deleterious effect determine DiHOME Diol disease Eicosanoids EpOME fatty Fatty acid homeostasis hospitalized patient increases in Inflammation Inflammatory response Injury investigated involved leukotoxin linoleate diol Lipid lipid mediator lipid mediators metabolism outcome pathway Patient perivascular plasma plasma sample Potential Quantitative regulate Regulatory reported rodent Sepsis severe pulmonary involvement Signaling Symptoms Toxicity vascular permeability
[DOI] 10.3389/fphys.2021.663869 PMC 바로가기 [Article Type] Physiology

No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity

질병 중증도가 다른 COVID-19 환자의 회복기 혈장에서 SARS-CoV-2 RNA가 검출되지 않음

Article

Published on 2021-04-012022-09-11
Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 asymptomatic patients Blood Chain Reaction collected Comorbidities contribute convalescent convalescent plasma coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients date of onset defined demographics disappearance disease severity Donor donor blood donors initial symptom initial symptoms investigated Japan male mechanical ventilation median age median time Mild moderate oxygen oxygen demand Passive passive immunization Patient patients plasma sample plasma samples Plasma transfusion Pneumonia polymerase chain polymerase chain reaction positive potential therapy proof Quality control real-time polymerase chain reaction recovered COVID-19 patient Recovered COVID-19 patients report resolved RNA SARS-CoV-2 SARS-CoV-2 RNA screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease severe symptoms severity treating COVID-19 patient Treatment
[DOI] 10.1016/j.jiac.2021.01.004 PMC 바로가기 [Article Type] Article