Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ FailurePharmacology Published on 2020-11-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute lung injury acute respiratory distress adverse event AEs Affect Alpha Anti-inflammatory anti-inflammatory agents ARDS Cancer clinical Clinical course Clinical practice clinical study Compliance complications coronavirus disease COVID-19 COVID-19 patient Cytokine release syndrome dose-dependent dose-escalation double-blind evaluate examined exhibited failure GRADE growth factor healthy histopathological examination Human ICH include Inflammatory cytokine ingredient interleukin-6 intravenous Liver damage Model mortality rate mouse multi-organ dysfunction multi-organ failure Necrosis New niacinamide Patient patients phosphate placebo-controlled platform Pneumonia potent Preclinical Prevent profile Protective Pulmonary edema Randomized reduce respiratory response Riboflavin SAEs Safety safety profile Sepsis Serious Adverse Event Shock show Standard statistical analysis subject subjects survival syndrome Tolerability Treatment was performed [DOI] 10.3389/fphar.2020.594321 PMC 바로가기 [Article Type] Pharmacology
Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitroVeterinary Science Published on 2020-11-062022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] absence Adaptive immune response Against Antiviral antivirals biotherapeutic agent bovine bovine IFN-λ Cell cells circulating COVID-19 demonstrated effective epithelial expressed Health HEK-293 cell higher affinity Human human PBMC IC50 identity IFN IFN-λ in silico in vitro inhibitory concentration Interaction lack Lambda lung mucosal surfaces non-specific other respiratory virus polymorphism potent produced proinflammatory receptor reduce reduced respiratory viral infections respiratory viruses SARS-CoV-2 SARS-COV-2 infection tested therapeutic therapy These cells Toxicity Transmission Type I IFN type I IFNs variants viral infections virus [DOI] 10.3389/fvets.2020.603622 PMC 바로가기 [Article Type] Veterinary Science
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamideCell Death & Injury Published on 2020-10-302022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, SARS, [키워드] activated Activation ADP-ribose Aryl hydrocarbon receptor ATP biochemical Cancer caused cell death chronic obstructive clinical care component COPD Coronaviruses COVID-19 Critical cytokine determine drugs effective Efficacy ENhance enzyme event expression Gene Expression glucocorticoid Glucocorticoids HIV infection homologue Immunity Immunotherapy Indoleamine 2,3-dioxygenase induce information inhibit inhibitor intensive care Kynurenine pathway lung Lung injury NADP nicotinamide nuclear overexpressed PARP pathophysiology Patient patient mortality Poly (ADP-ribose) polymerase polymerase potent Prevent proinflammatory Proinflammatory cytokine pulmonary disease regulate Regulation respiratory syncytial virus RSV sequence silent sirtuin therapeutic use therapy Trial [DOI] 10.1042/BSR20202856 PMC 바로가기 [Article Type] Cell Death & Injury
Subunit Nanovaccine with Potent Cellular and Mucosal Immunity for COVID-19COVID-19에 대한 강력한 세포 및 점막 면역을 가진 서브유닛 나노백신Article Published on 2020-09-212022-09-12 Journal: ACS applied bio materials [Category] MERS, SARS, 진단, [키워드] activating acute respiratory syndrome adjuvants alum adjuvant cationic CD4 CD8 cells cellular cellular immunity coronavirus COVID-19 CpG elicit humoral humoral immune response Humoral immunity IgA antibody Immunity infecting inhibit SARS-CoV-2 Liposome mice nanoadjuvant nanovaccine pandemic potent receptor SARS-CoV-2 sera significantly strong T-cell the S1 subunit Vero cells virus [DOI] 10.1021/acsabm.0c00668 PMC 바로가기 [Article Type] Article
Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against CoronavirusesReview Published on 2020-09-212022-10-28 Journal: Plants [Category] COVID-19, [키워드] 3CLpro ACE-2 receptor Analysis Antiviral antiviral activity Antiviral compound antiviral property bioactive compounds Biomolecule Combination Compound coronavirus Coronaviruses correlation COVID-19 Critical develop drugs effective Efficacy ethnobotany Evidence human diseases increased mortality insight medicinal plant MERS-CoV metabolites natural products New pandemic disease Phytomedicine plant plants potent protocol researcher Safe SARS-CoV SARS-CoV-1 SARS-COV-2 infection targets therapeutic therapeutic agent Vaccine Viral protein [DOI] 10.3390/plants9091244 PMC 바로가기 [Article Type] Review
Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal PlantsResearch Article Published on 2020-09-122022-10-28 Journal: Scientifica [Category] COVID-19, [키워드] African analysed antiviral therapy candidate China Chinese compounds COVID-19 pandemic distribution docking eight identification Luteolin metabolism molecule Multiple natural pandemic plant potent reported Repurposed drugs SARS-CoV-2 screened Spread subset target targets therapeutic therapeutic targets Toxicity Vaccine Verbena officinalis Vitis Wuhan, China ZINC database [DOI] 10.1155/2020/1878410 PMC 바로가기 [Article Type] Research Article
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerabilityCOVID-19 환자의 강력한 중화 항체는 취약성의 여러 대상을 정의합니다.Research Article Published on 2020-08-072022-09-14 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome addition antibody antigenic sites bind candidate competition complex Concentration convalescent convalescent COVID-19 patients coronavirus coronavirus disease COVID-19 COVID-19 patient described domain epitope Epitopes Guidance Health host cell host receptor inhibit measure Microscopy monoclonal antibody neutralize neutralizing antibody Patient potent prefusion RBD receptor SARS-CoV-2 SARS-COV-2 infection Science Site Spike protein Spread strong immune response subset target the antibody the patient the SARS-CoV-2 therapeutic Travel Treatment Vaccine design viral spike protein virus [DOI] 10.1126/science.abc5902 PMC 바로가기 [Article Type] Research Article
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 PatientsResearch article Published on 2020-07-132022-10-05 Journal: Cell [Category] SARS, 변종, [키워드] 2019-nCoV analyzed antibody approved drug B cell B cells COVID-19 COVID-19 pandemic COVID-19 patient Diagnosis different time point healthy individual identify implication longitudinal monoclonal antibody neutralized neutralizing antibody potent precursor precursors protective immune response public health SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sequence single B cell analysis somatic mutations the antibody response Treatment vaccination Vaccine [DOI] 10.1016/j.cell.2020.06.044 [Article Type] Research article
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibodySARS 코로나바이러스 특이적 인간 단일클론항체에 의한 2019 신종 코로나바이러스 스파이크 단백질의 강력한 결합Letter Published on 2020-02-172022-09-06 Journal: Emerging Microbes & Infections [Category] Communicable Disease, COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infections 2019-nCoV RBD 2019-nCoV spike protein ACE2 ACE2 binding site anti-SARS CoV antibodies anti-SARS CoV antibody antibody Antiviral treatment binding caused Combination CoV antibodies CR3014 CR3022 critical impact cross-reactivity deaths develop domain epitope epitope of CR3022 Health human infections Human monoclonal antibody identity implication laboratory-confirmed human infections m396 monoclonal antibodies monoclonal antibody Neutralizing antibodies Novel coronavirus overlap potent RBD Receptor-binding domain SARS-CoV SARS-CoV-specific human monoclonal antibody SARS-CoV-specific neutralizing antibodies SARS-CoV-specific neutralizing antibody specific neutralizing antibodies Spike protein the RBD therapeutic therapeutic antibodies Treatment Vaccine [DOI] 10.1080/22221751.2020.1729069 PMC 바로가기 [Article Type] Letter
Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4Article Published on 2019-01-142022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antiviral agent bat candidate caused cell–cell fusion coronavirus effective exhibited fusion fusion inhibitor high mortality high stability HKU4 Identified inhibitory activity MERS-CoV MERS-CoV infection Middle East outbreak peptide peptides potent reported respiratory syndrome coronavirus spike Spike protein suggested viral infection [DOI] 10.3390/v11010056 PMC 바로가기 [Article Type] Article