potential therapeutic target
[용어속성] Term
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19
Research article
[키워드] alteration
Biomarker
Biomarkers
Coagulation
Cohort
combinations
contribute
coronavirus disease
COVID-19
COVID-19 patients
degranulation
ELISA
enzyme-linked immunosorbent
global public health
host response
identify
immune
independent
Inflammatory responses
knowledge
metabolism
Mild
non-survivor
outcomes
pandemic
Pathogenesis
pathophysiological
Pathways
plasma
plasma proteomics
Platelet
potential therapeutic target
predicted
Protein
Proteins
proteomics
SARS-CoV-2
severe symptoms
survivor
[DOI] 10.1016/j.immuni.2020.10.008 [Article Type] Research article
[DOI] 10.1016/j.immuni.2020.10.008 [Article Type] Research article
Neuroinflammation after surgery: from mechanisms to therapeutic targets
Reviews
[키워드] Affect
affecting
arising
Brain
Central nervous system
Complication
conditions
Critical
delirium
disorders
example
hallmark
immune system
Inflammation
Interaction
Intervention
intrinsic
limb
mechanism
neurodegeneration
neurologic
potential mechanism
potential therapeutic target
Regulation
surgical
therapeutic target
tissue homeostasis
trauma
triggered
variety
[DOI] 10.1038/s41590-020-00812-1 [Article Type] Reviews
[DOI] 10.1038/s41590-020-00812-1 [Article Type] Reviews
Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology
Research
[키워드] activated
Activation
Active ingredient
ALB
albumin
Analysis
Anti-inflammatory
AutoDock
B cell
binding activity
biological process
BPS
cascade
CASP3
cellular response
Chinese
component
Compound
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 disease
Cytoscape
Cytoscape software
database
demonstrated
disease
docking score
Effect
effective
Effector mechanism
Effects
EGFR
endothelial
enrichment analysis
epidermal
ESR1
estrogen receptor
Examining
explain
Extracellular
GAPDH
GeneCard
Genes
growth factor
IL-2
Inflammation
ingredient
injection
International
JUN
KEGG
Kyoto
less
MAPK
MAPK1
MAPK14
MAPK8
mechanism
Mild
molecular docking
Necrosis
network pharmacology
NF-κB
nuclear
Ontology
participated
Pathways
pharmacological mechanism
PI3K
potential mechanism
potential therapeutic target
PPI
predict
produced
Protein
protein-protein interaction
provided
PTGS2
RAS
receptor
regulated
Regulation
renin-angiotensin system
Result
searched
Sepsis
severe pneumonia
signaling pathway
STAT3
SwissTargetPrediction database
synergistic
T-cell receptor
target
targets
therapeutic effect
TLR
TNF
Toll-like receptor
Topology
Transcription
Treatment
TRP
VEGF
was used
Xuebijing
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research
Furin: A Potential Therapeutic Target for COVID-19
Article
[키워드] Analysis
anti-parasitic drug
approved drug
Betacoronavirus
Compound
Computational Molecular Modelling
concerning
COVID-19
disease
drugs
Effect
Efficiency
furin
furin cleavage site
highest
hydrolyzed
inhibitor
inhibitory effect
International
membrane fusion
motif
other coronaviruses
Potential
potential therapeutic target
Protein
public health emergency
responsible
SARS-CoV-2
SARS-CoV-2-S
screened
spike
target
the Spike
Treatment
unique
Virology
Virtual screening
[DOI] 10.1016/j.isci.2020.101642 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.isci.2020.101642 PMC 바로가기 [Article Type] Article
Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms
Research article
[키워드] analysed
antibody panel
Antigen
approach
Biomarker
CD11b
Cell
circulating leukocyte
clinically
Complement receptor 3
count
COVID-19
COVID-19 patient
COVID-19 patients
cytokine release
develop
diagnostic
eight
examined
explain
feature
febrile
fibrinogen
finding
flow cytometry
granulocyte
healthy volunteers
hypoxia
hypoxic
Immunological memory
Immunology and inflammation
Increased
infected individual
Infection
Inflammatory
innate immune cell
innate immune response
innate immune system
leukocyte
leukocyte activation
Level
memory
Mild symptom
mild symptoms
monocyte
natural
NK cell
over-expression
Patient
patients with COVID-19
Pneumonia
potential therapeutic target
Rapid
receptor
remained
required
Respiratory complications
Respiratory failure
specimen
subsequent
Therapeutics
thrombotic
understanding
Ventilated
ventilatory support
with COVID-19
[DOI] 10.1016/j.ijid.2020.08.004 [Article Type] Research article
[DOI] 10.1016/j.ijid.2020.08.004 [Article Type] Research article
How COVID-19 induces cytokine storm with high mortality
Review
[키워드] Activation
acute respiratory distress
acute respiratory syndrome
alveolar epithelial cell
ARDS
caused
Cell
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
COVID-19 patients
Cytokine storm
dependent on
endothelial cells
high mortality
IL-6
induce
Inflammation
interleukin-6
mechanism
NF-κB
NF-κB signaling
non-immune
nuclear
pathogenic
pathway
potential therapeutic target
regulate
reported
SARS-CoV-2
severity
Signaling
Spread
STAT3
stimulated
Symptom
syndrome
the cytokine storm
therapeutic target
Transcription
Wuhan, China
[DOI] 10.1186/s41232-020-00146-3 PMC 바로가기 [Article Type] Review
[DOI] 10.1186/s41232-020-00146-3 PMC 바로가기 [Article Type] Review
Serum proteins may facilitate the identification of Kawasaki disease and promote in vitro neutrophil infiltration
Article
[키워드] activated
Adhesion Molecule
Affect
age
antibody
applied
attenuate
Biomarkers
cause
children
clinically
conducted
DEFA1
demonstrated
develop
Developing
Diagnosis
diagnostic
Diseases
ELISA
endothelial
endothelial cells
enrolled
evaluate
facilitate
glycoprotein
immune
immunology
in vitro
in vitro study
infiltration
Inflammatory
Kawasaki disease
lesion
leukocyte
Medical research
Molecular medicine
neutrophil
neutrophil infiltration
neutrophil surface
neutrophil-like cell
ORM1
Pathogenesis
pathogenic
patients
potential mechanism
potential therapeutic target
PRDX2
promote
promoted
Protein
Proteins
proteomics
reducing
responsible
rheumatology
risk
robust
S100A12
S100A8
S100A9
Satisfaction
serum
Serum protein
significantly
subject
Treatment
[DOI] 10.1038/s41598-020-72695-z PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-020-72695-z PMC 바로가기 [Article Type] Article
Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology
Research
[키워드] ACE
ACE2
Analysis
approach
BCL2L1
BDKRB2
benefit
biological function
cascades
CASP3
Chinese
clusterProfiler package
co-expressed
Coagulation
Compound
coronavirus disease
COVID-19
cytoHubba
Cytoscape
drug-likeness
effective
effort
EGFR
enrichment
enrichment analysis
Epidemic
ESR1
FPR2
function
Granule
help
HIF-1
Immunity
Inflammatory
Inflammatory response
ingredient
kaempferol
knowledge
Luteolin
MAPK signaling
mechanism
mediated immunity
Mild
MPO
network pharmacology
neutrophil
Ontology
oral bioavailability
pathway
patients
performed
pharmacological mechanism
PI3K-Akt signaling
potential mechanism
potential therapeutic target
potential therapeutic targets
predict
progression
protein-protein interaction
quercetin
R software
Regulation
Result
screenings
signaling pathway
signaling pathways
STAT3
Stress
suggested
Symptoms
target
TCMSP
the disease
therapeutic
Topology
Toujie Quwen granule
Treatment
treatment for COVID-19
Venn diagram
was performed
was used
were used
[DOI] 10.1186/s13040-020-00225-8 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s13040-020-00225-8 PMC 바로가기 [Article Type] Research
STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID‐19 therapy
Short Communication
[키워드] ACE2
ACE2 expression
Affect
cause
cell entry receptor
contribute
COVID‐19
COVID‐19 patients
COVID‐19
event
expression
increase in
isoform
molecular
opposite
potential therapeutic target
progression
SARS‐CoV‐2
STAT3
STAT3 isoforms
STAT3α
STAT3β
the disease
therapy
virus
[DOI] 10.1111/jcmm.15838 PMC 바로가기 [Article Type] Short Communication
[DOI] 10.1111/jcmm.15838 PMC 바로가기 [Article Type] Short Communication