A multi-step machine learning approach to assess the impact of COVID-19 lockdown on NO 2 attributable deaths in Milan and Rome, ItalyResearch Published on 2022-01-162022-11-01 Journal: Environmental Health [Category] Coronavirus, SARS, [키워드] Air pollution Annual approach citizen science Compliance Concentration COVID-19 dataset death deaths distribution effective European experiment Factor forest Health Health Impact Assessment Italian Italy land limit lockdown machine learning measure network prevented Quality Regulation Result Rome scenario supplementary material took place Variability [DOI] 10.1186/s12940-021-00825-9 PMC 바로가기 [Article Type] Research
Symptomatic SARS-CoV-2 Infection with Ageusia after Two mRNA Vaccine DosesCase Report Published on 2022-01-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adopted Ageusia BNT162b2 Pfizer vaccine Case report coronavirus COVID-19 COVID-19 pandemic dental practitioner determine Diagnosis Efficacy healthcare worker immunization individual Infection investigated Loss marker mRNA nasal congestion Patient performed Personal protective equipment postvaccination prevented preventive measure protocol raise reported symptoms SARS-CoV-2 Spread Swab symptomatic infection symptomatic infections symptomatic SARS-CoV-2 infection Trial vaccination Vaccine Viral genome sequencing [DOI] 10.3390/ijerph19020886 PMC 바로가기 [Article Type] Case Report
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologyACE2는 TNF- 및 IFNγ-유도 면역병리학을 가진 새로운 COVID-19 마우스 모델에서 SARS-CoV-2에 대한 중요한 생체 내 수용체입니다Research Article Published on 2022-01-132022-09-12 Journal: eLife [Category] 진단, [키워드] ACE2 adaptive BALB/c C57BL/6 COVID-19 COVID-19 mouse model COVID-19 therapy Critical Cytokine storm dependent on disease severity Factor Genetic human disease IFNγ Immune cell infiltration Immunity immunological immunopathology in vivo inhibition Interaction lymphopenia maVie16 mice mouse mouse-adapted SARS-CoV-2 murine Mutation pathology Pneumonia prevented Proinflammatory cytokine receptor recombinant ACE2 recombinant soluble ace2 reduced replicated resulting SARS-CoV-2 spike therapy TNF Treatment [DOI] 10.7554/eLife.74623 PMC 바로가기 [Article Type] Research Article
Incidence of common infectious diseases in Japan during the COVID-19 pandemicResearch Article Published on 2022-01-122022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] activities adopted Analysis change common Contact correlated correlation COVID-19 COVID-19 pandemic disease Diseases droplet transmission Enterobacteriaceae Epidemic evaluated examined Exanthema incidence Infection Infectious disease Infectious diseases Influenza Japan Japanese people Lower National Novel coronavirus pandemic prevented Public health intervention recent report respiratory infectious disease selected significantly lower Spread suppressed the disease Transmission transmitted wearing mask Weekly [DOI] 10.1371/journal.pone.0261332 PMC 바로가기 [Article Type] Research Article
Vertical integration of primary care practices with acute hospitals in England and Wales: why, how and so what? Findings from a qualitative, rapid evaluationHealth Services Research Published on 2022-01-112022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, SARS, [키워드] Analysis Care COVID-19 pandemic develop England finding Health Health policy health system hospital implementation Local maintain management National Health Service notable objective observation Patient Patient care Physicians prevented primary care qualitative research Result risk secondary care vertical [DOI] 10.1136/bmjopen-2021-053222 PMC 바로가기 [Article Type] Health Services Research
Photodynamic Inactivation of Human CoronavirusesArticle Published on 2022-01-082022-10-28 Journal: Viruses [Category] COVID-19, [키워드] absence Antiviral antiviral activity Antiviral effect antiviral property assays Betacoronavirus concentrations coronavirus CoVs cultured cell damaged demonstrated digestion dose-dependent manner doses emodin expand experiments HCoV-229E HCoV-OC43 herpes simplex Human human cells human coronavirus inactivation inhibited lentivirus Local microorganisms natural product oxygen PDI photodynamic inactivation photosensitizer PhytoQuin prevented Protein pseudotyped reactive oxygen specy Replication RNase ROS S protein SARS-CoV-2 spike susceptible the SARS-CoV-2 Viral RNA virus viruses [DOI] 10.3390/v14010110 PMC 바로가기 [Article Type] Article
A second functional furin site in the SARS-CoV-2 spike proteinCoronaviruses Published on 2022-01-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] 293T-ACE2 cell antiviral therapy bioinformatic analysis canonical cathepsin L cell–cell fusion cells cleavage cleavage site deleted eliminated enzyme functional furin furin site Infection Infectivity inhibitor mutant mutated Mutation not affect pathogenesis of SARS-CoV-2 polybasic prevented proteolytic pseudovirus RaTG13 S2’ cleavage SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus Spike protein the SARS-CoV-2 the spike protein TMPRSS2 virus infection [DOI] 10.1080/22221751.2021.2014284 PMC 바로가기 [Article Type] Coronaviruses
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice줄기 루프 RNA RIG-1 작용제는 쥐의 급성 및 만성 SARS-CoV-2 감염으로부터 보호합니다Article Published on 2022-01-032022-09-10 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 치료제, [키워드] absence acute SARS-CoV-2 infection adaptive immune system Antiviral demonstrated disease effective Efficacy elicited Immunocompromised immunosuppressed patients in viral Infection injection Innate immunity Lower respiratory tract Medical countermeasures mice morbidity morbidity and mortality mouse model Mouse models Post-infection prevented Prophylactic PROTECT Protective respiratory retained RIG-I RNA SARS-CoV-2 SARS-COV-2 infection severe disease single dose therapeutic therapeutic agent therapeutic potential therapy Treatment type I interferon variants variants of concern Viral viral control viral infection virus VOCs [DOI] 10.1084/jem.20211818 PMC 바로가기 [Article Type] Article
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변종으로부터 보호하는 다양한 백신 플랫폼Article Published on 2022-01-012022-09-11 Journal: Expert review of vaccines [Category] SARS, 변종, [키워드] Administered administration appearance Area co-morbidities co-morbidity COVID-19 COVID-19 transmission COVID-19 vaccine COVID-19 vaccines death diverse dose doses Efficacy expert greater Hospitalization hospitalizations individual mitigate Mitigation mixing morbidities pandemic platform platforms prevented PROTECT SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose significantly vaccination Vaccine vaccine platform Vaccines variant variants vulnerable patient vulnerable patients [DOI] 10.1080/14760584.2022.1997601 PMC 바로가기 [Article Type] Article
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infectionCOVID-19 감염에 대한 바이러스 유사 입자 백신의 개발 및 전임상 평가Article Published on 2022-01-012022-09-12 Journal: Allergy [Category] SARS, 진단, [키워드] AFM alum anti-N IgG anti-RBD anti-S breadth cellular characterized COVID-19 COVID-19 infection CpG CpG ODN Adjuvant demonstrated development elicited expressing HEK293 cell HEK293 cells humoral immune response Humoral immunity identity immune immunized immunoblotting immunogenic Live virus Lung pathology multifunctional prevented PROTECT Protein protein antigen pulse purified reduced SARS-CoV-2 SARS-CoV-2 antigen SEM structural protein T-cell responses TEM transiently transfected triggered vaccination Vaccine virus load Virus-like particle virus-like particle vaccine VLP VLPs [DOI] 10.1111/all.15091 PMC 바로가기 [Article Type] Article