A Survey Among Italian Physicians During COVID-19 Outbreak. Could Bacillus Calmette–Guérin Vaccine Be Effective Against SARS-CoV2?Pharmacology Published on 2021-05-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Against age asymptomatic form Bacille Calmette-Guerin vaccine Bacillus BCG BCG vaccination clinically Cohort Committee Contact COVID-19 COVID-19 infection Data analysis demonstrated distress Epidemiological study Epidemiology evaluate Evidence Infection Innate immunity Italian Natural killer cells no significant difference occurred pauci-symptomatic performed period prevalence physician Pneumonia Prevalence prevalence of COVID-19 professional protective role questionnaire SARS-CoV2 SARS-CoV2 infection subject survey the WHO trained immunity trials vaccination Vaccine was performed was recorded were infected were recorded were used WHO [DOI] 10.3389/fphar.2021.646570 PMC 바로가기 [Article Type] Pharmacology
Emergence and outcomes of the SARS-CoV-2 ‘Marseille-4’ variantSARS-CoV-2 '마르세유-4' 변종 출현과 결과Article Published on 2021-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed animal reservoir caused clade clinical feature coronavirus COVID-19 demographic diagnosed diagnoses emergence Epidemic evaluated France hallmark Hypoxemia Illumina involved IQ-TREE Laboratory lack Marseille Marseille-4 Molecular epidemiology mutations Next-generation sequencing occurred outbreak outcome Patient protective immunity protective role qPCR qPCR assay Re-infection Receptor binding domain S477N SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 strain SARS-CoV-2 variant spike Spike protein strain Strains the SARS-CoV-2 the spike protein tree Vaccine Vaccines variant variants whole genome sequence [DOI] 10.1016/j.ijid.2021.03.068 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold CoronavirusesSARS-CoV-2-혈청 음성 피험자, 감기 코로나바이러스에 교차 반응하는 SARS-CoV-2 핵단백질의 CTL 에피토프 표적Clinical Trial Published on 2021-04-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료제, [키워드] Amino acid analyzed Antiretroviral therapy Beta beta-coronavirus CD4 CD8 CD8+ T-cell circulating Cohort Cold common common cold common cold coronavirus Concentration contribute Course COVID-19 cross-reactive CTL CTL epitope delineation epitope Epitopes healthy donors HIV-1 HIV-1 infection HKU1 HLA allele HLA alleles HLA-A HLA-A*02 HLA-B homologous homology induce Infection majority Mild nucleoprotein observation OC43 Patient peptide peptides potential risk Prospective Study protective role reason risk factor Risk factors SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection SARS-CoV-2 nucleoprotein sequence severe COVID-19 severe disease subject susceptibility T-cell T-cell epitope T-cell Response T-cell responses T-cells target the SARS-CoV-2 treated [DOI] 10.3389/fimmu.2021.627568 PMC 바로가기 [Article Type] Clinical Trial
Does the End Justify the Means? The Role of Organizational Communication among Work-from-Home Employees during the COVID-19 Pandemic목적이 수단을 정당화하는가? COVID-19 팬데믹 기간 동안 재택 근무 직원 간의 조직 커뮤니케이션의 역할Article Published on 2021-04-082022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술, [키워드] association buffer changes communication contributed COVID-19 COVID-19 emergency crisis detect disorder disorders early stage Effects employee End ENhance equation functional Health implication involved Italy mandatory mediators Model organizational communication outcome protective role psycho-physical disorders raised reduction remote working Research resource role Self-efficacy technostress [DOI] 10.3390/ijerph18083933 PMC 바로가기 [Article Type] Article
Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital3차 의뢰 병원에 입원한 COVID-19 환자의 비타민 D 25OH 결핍Article Published on 2021-04-012022-09-11 Journal: Clinical nutrition (Edinburgh, Scotland) [Category] MERS, SARS, 바이오마커, [키워드] 95% CI adult COVID-19 patient association clinical feature Clinical outcome clinical outcomes cohort study confounders coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient deficiency determine disease disease severity enrolled hospital Hospital admission Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients in-hospital mortality Intervention Italian logarithmic scale marker moderate Mortality Odds ratio outcome outcomes positive Prevalence prevalent protective role raised Serum level severe COVID-19 patients severe deficiency single-center tertiary referral hospital trials variables Vitamin Vitamin D Vitamin D 25OH. vitamin D deficiency vitamin D insufficiency vitamin D levels were assessed with COVID-19 [DOI] 10.1016/j.clnu.2020.10.055 PMC 바로가기 [Article Type] Article
Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern ItalyArticle Published on 2021-03-192022-10-28 Journal: Biology [Category] COVID-19, [키워드] 25-hydroxy vitamin D addition age allergy approach area of interest association Biological functions change changes in Concentration Daily dose Effect excluded experimental evidence feature First wave group groups Health hospital individual investigated Italy less Level lockdown obesity pandemic Patient protective role recorded reduced risk Respiratory tract infections SARS-COV-2 infection SARS-CoV-2 positivity second wave severity of COVID-19 simple sun exposure susceptibility sustained the SARS-CoV-2 variable Vitamin D vitamin D level Vitamin D status Vitamin D supplementation was obtained Wave [DOI] 10.3390/biology10030237 PMC 바로가기 [Article Type] Article
Reassessing IVIg therapy in chronic inflammatory demyelinating polyradiculoneuropathy during COVID-19: a chance to verify the need for chronic maintenance therapyCOVID-19 기간 동안 만성 염증성 탈수초성 다발성 신경근신경병증에서 IVIg 요법 재평가: 만성 유지 요법의 필요성을 확인할 기회Article Published on 2021-03-012022-09-12 Journal: Neurological Sciences [Category] SARS, 진단, [키워드] acute respiratory syndrome administration analyzed caused CIDP Clinical deterioration COVID-19 demonstrated Follow-up Health health facilities immunotherapies increased risk Inflammatory IVIG Novel coronavirus outbreak pandemic Patient protective role raised repeated reported risk SARS-CoV-2 SCIg. selected the patient therapy treated Treatment [DOI] 10.1007/s10072-020-04983-5 PMC 바로가기 [Article Type] Article
COVID-19 in people living with HIV: Clinical implications of dynamics of the immune response to SARS-CoV-2HIV 감염자의 COVID-19: SARS-CoV-2에 대한 면역 반응 역학의 임상적 의미Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission antiretroviral drugs Antiretroviral therapy CD4+ Cellular immune response clinical clinical picture coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines disease severity dysregulation elicited Evidence evidence of FIVE greater highest HIV HIV infection HIV patients immune activation immune response Immunoglobulin Immunoglobulin G immunological Immunosuppression implication increased risk Inflammatory maximum Mild Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody occurred on admission Patient patients PLWH Pneumonia Proinflammatory cytokine proinflammatory cytokines protective role reported respiratory Respiratory failure RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 T-cell activation two patients Viral viral clearance with COVID-19 with HIV [DOI] 10.1002/jmv.26556 PMC 바로가기 [Article Type] Article
Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins니코틴성 콜린성 시스템과 코로나19: α7 니코틴성 아세틸콜린 수용체와 SARS-Co-V 및 SARS-CoV-2 스파이크 당단백질의 비밀 에피토프 간의 상호작용에 대한 실리코(in silico) 식별Article Published on 2021-03-012022-09-12 Journal: Food and chemical toxicology : an international jo [Category] SARS, 유전자 메커니즘, 진단, [키워드] adverse outcome agonists anti-SARS-CoV antibody binding site Clinical effect conformations coronavirus COVID-19 CR3022 Cryptic epitope diagnosed dysregulated epitope glycoprotein higher odd homology Hospitalized Hypothesis Interaction less molecular complex Molecular modeling monoclonal antibody nAChRs. pathway protective role protein complex receptor SARS-Co-V SARS-CoV SARS-CoV-2 sequence shown smoker spike spike glycoprotein Spread Support the Spike therapeutic Wuhan [DOI] 10.1016/j.fct.2021.112009 PMC 바로가기 [Article Type] Article
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity Research Published on 2021-02-252022-10-05 Journal: Nature Medicine [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] adverse outcomes Analysis circulating controls COVID-19 COVID-19 susceptibility death European Evidence Hospitalization identify increase in individual individuals isoform mendelian randomization Neanderthal non-infectious OAS1 Odds ratio pharmacological agent plasma PROTECT protective role Protein reduced reducing severity suggested Support susceptibility Ventilation [DOI] 10.1038/s41591-021-01281-1 [Article Type] Research