Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Many Keys Unlock the Doors for Virus Entry많은 키가 바이러스 진입을 위한 문을 엽니다Comment Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] activities cathepsin characterized complexes component components coronavirus Coronaviruses door endocytic endosome Endosomes Filovirus filoviruses Genome host cells inactivation infect Influenza Influenza virus mBio membrane membrane fusion promote protease Protein protein complex protein complexes Proteins raise respond SARS-CoV-2 variant Trigger vacuolar vesicles virus virus entry VPS29 zoonotic [DOI] 10.1128/mbio.00445-22 PMC 바로가기 [Article Type] Comment
Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips전기화학적 면역센서/압타센서 지원 바이오칩을 이용한 코로나19 항원 및 항체의 빠르고 민감한 다중 검출Article Published on 2022-06-282022-09-11 Journal: Chemical communications (Cambridge, England) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] antibody Antigen aptamer clinical samples Community COVID-19 Diagnosis IgG antibody multiplex nucleocapsid Protein Proteins Rapid SARS-CoV-2 spike [DOI] 10.1039/d2cc01598f PMC 바로가기 [Article Type] Article
SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassemblySpySwitch는 플러그 앤 디스플레이 나노 어셈블리를 위한 pH 또는 열 반응성 캡처 및 릴리스를 지원합니다.Article Published on 2022-06-282022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Bacterial binding site Culture determine ENhance EY6A Final flexible generate histidine mammalian moderate Neutral New coronavirus pandemic Protein Proteins purification Receptor-binding domain Resilience Sarbecoviruses SARS-CoV-2 tested Threats Vaccine development [DOI] 10.1038/s41467-022-31193-8 PMC 바로가기 [Article Type] Article
Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation Research Published on 2022-06-222022-10-05 Journal: Acta pharmacologica Sinica [Category] 바이오마커, [키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4 [DOI] 10.1038/s41401-022-00933-3 [Article Type] Research
Antibodies to combat viral infections: development strategies and progressReview Published on 2022-06-202022-10-05 Journal: Nature Reviews Drug Discovery [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료제, [키워드] acute respiratory syndrome antibody Antigen boost can be used caused Characteristics coronavirus COVID-19 COVID-19 pandemic develop Diseases Ebola virus effort Emergency use ENhance HCMV Human Cytomegalovirus immune responses in viral Infection Influenza mAb mAbs Neutralizing protective immune response Proteins Region respiratory syncytial virus RSV SARS-CoV-2 specificity stimulated therapeutic Vaccine design Vaccine development viral infection virus [DOI] 10.1038/s41573-022-00495-3 [Article Type] Review
In vitro study on efficacy of PHELA, an African traditional drug against SARS-CoV-2 Research Published on 2022-06-192022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 비임상, 치료제, [키워드] ACE2 African angiotensin-converting enzyme 2 apparition approved average binding energy Clerodendrum Combination Compound Concentration coronavirus COVID-19 docking study Efficacy exotic Gladiolus highest affinity IC50 in silico in vitro Infection Interaction investigated MERS-CoV infection other compound pathogenic plant Protein Proteins receptor SARS-CoV SARS-CoV infection SARS-CoV-2 therapeutic therapy for COVID-19 vaccinated individual Vaccine vaccine candidate [DOI] 10.1038/s41598-022-13599-y [Article Type] Research
Electrochemical Determination of Interaction between SARS-CoV-2 Spike Protein and Specific AntibodiesSARS-CoV-2 스파이크 단백질과 특정 항체 간의 상호작용에 대한 전기화학적 측정Article Published on 2022-06-172022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody Antigen antigen-antibody complex condition confirmation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic voltammetry (CV) Determination Diagnosis diagnosis of COVID-19 Effectiveness electrochemical immunosensor electrochemical impedance spectroscopy (EIS) gold modifications observé polyclonal presence of antibody Proteins recombinant respiratory SAM SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 proteins SARS-CoV-2 spike protein self-assembled monolayer (SAM) serologic diagnosis serological Serological diagnosis severe acute respiratory syndrome Coronavirus Specific specific antibodies spike Spike protein Spike proteins spike proteins (rSpike). the SARS-CoV-2 vaccination was used [DOI] 10.3390/ijms23126768 PMC 바로가기 [Article Type] Article
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIaRANBP2 및 USP9x는 아데노바이러스 마이너 코트 단백질 IIIa의 핵 수입을 조절합니다Article Published on 2022-06-162022-09-11 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] accumulation acute respiratory illness acute respiratory illnesses Adenovirus Affinity purification Amino acid amino acids Analysis antiviral therapeutics antiviral therapy bind binding blockade C-terminus Cell cell nuclei cells cellular competition conjunctivitis counteract COVID-19 demonstrated deregulated disparate expression Host implication indicated infected cells Infection interact Interaction interactions mass spectrometry maturation mechanism Microscopy nuclear nuclei nucleus outbreak parasites protease Protein Proteins Ranbp2 reduced regulate respiratory pathogen retention subsequent surface plasmon surface plasmon resonance transmission electron microscopy Transport USP9x Vaccine viral genome replication Viral particles Viral protein virion virion assembly virus virus-infected cell virus-infected cells wild type [DOI] 10.1371/journal.ppat.1010588 PMC 바로가기 [Article Type] Article