RCT – Page 12 – Communicable Diseases Research

Signals were broadly positive for months, but never definitive: the tocilizumab story

신호는 몇 달 동안 대체로 긍정적이었지만 결코 확정적이지 않았습니다: tocilizumab 이야기

Review

Published on 2022-03-012022-09-12
Journal: Clinical microbiology and infection : the official [Category] SARS, 신약개발, 진단,

The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19

COVID-19에 대한 무작위 임상 시험에서 통계적으로 유의미한 결과의 취약성

Article

Published on 2022-03-012022-09-11
Journal: JAMA Network Open [Category] 임상,

Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies

코로나19 예방 및 치료에 있어서 프로폴리스와 꿀의 잠재적 효과: in silico 및 임상 연구에 대한 체계적인 검토

Review

Published on 2022-03-012022-09-11
Journal: Journal of integrative medicine [Category] SARS, 임상, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant therapy angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Case report case reports Case series case sery clinical evidence Clinical improvement Clinical studies clinical study clinical symptom Clinical symptoms Cochrane Library Compound concerning conducted controlled trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptom data extraction database decrease disease Effect enzyme evaluated Evidence Future Honey IMPROVE in silico In silico methods independent indicated Infection mechanism Mild moderate-to-severe COVID-19 patients molecular docking narrative Patient positive Potential potential mechanism Propolis protease Randomized controlled trial RCT RCTs Replication RNA-dependent RNA polymerase sample sizes SARS-CoV-2 severe acute respiratory syndrome Coronavirus silico studies silico study Spike protein Standard of care standardized data extraction systematic review target protein target proteins therapy Treatment viral clearance viral entry Viral RNA was used were used
[DOI] 10.1016/j.joim.2022.01.008 PMC 바로가기 [Article Type] Review

Efficacy and mechanisms of traditional Chinese medicine for COVID-19: a systematic review

Review

Published on 2022-02-282022-11-01
Journal: Chinese Medicine [Category] COVID-19,

[키워드] addition Anti-inflammation Anti-inflammatory antiviral target Chinese Clinical symptoms cohort study component coronavirus disease Coronavirus disease 2019 COVID-19 Critical curtail database decrease demonstrated Efficacy evaluate Hospital stay Immunity IMPROVE involved Laboratory mechanism mechanisms Meta-analysis molecular docking mortality rate outbreak Patient proportion provided Randomized controlled trial RCT RCTs Regulation Research Retrospective study review searched Severe case suggested supplementary material systematic review target TCM the epidemic Traditional Chinese medicine was performed
[DOI] 10.1186/s13020-022-00587-7 PMC 바로가기 [Article Type] Review

Digitalized Cognitive Behavioral Interventions for Depressive Symptoms During Pregnancy: Systematic Review

Review

Published on 2022-02-232022-10-30
Journal: Journal of Medical Internet Research [Category] Coronavirus, COVID19(2023년), MERS, SARS,

[키워드] antenatal depression approach approaches carried CBT China CINAHL cognitive Cognitive behavior therapy Controlled country COVID-19 COVID-19 pandemic database Depression Digital interventions effect size effective Efficacy elements English Evidence expand Features Future increase increasingly Intervention item knowledge mitigate Norway objective outcome Participants populations positive Pregnancy pregnant women Prevalence Prospective protocol PsycINFO Randomized controlled trial randomized trials ranged RCT RCTs Registered Registration Reporting Result review risk of bia Sample size shown Symptom Symptoms systematic review The United States therapy Web of Science
[DOI] 10.2196/33337 PMC 바로가기 [Article Type] Review

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

캐나다에서 COVID-19로 병원에 입원한 환자의 치료를 위한 Remdesivir: 무작위 대조 시험

Randomized Controlled Trial

Published on 2022-02-222022-09-11
Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), SARS, 임상, 치료제,

[키워드] 95% CI 95% confidence interval adverse event age Analysis assigned baseline Canada changes in Characteristics clinical outcomes Clinical severity conjunction Consent Controlled trial COVID-19 creatinine Data collection defined demographics dialysis duration of symptom Effect enrolment evaluated event followed by groups Health care health care systems Health Organization health systems hepatic dysfunction hospital Hospital mortality Hospital stay hospitals in-hospital mortality incidence intravenously mechanical ventilation mechanically ventilated Mortality no difference Open-label outcome oxygen Patient patients performed Pragmatic Primary outcome Randomized Randomized controlled trial randomized patient RCT receive receiving Relative risk Remdesivir risk secondary Secondary outcomes severity of symptom Sex significant effect solidarity Solidarity trial standard care Standard deviation Standard of care Standard-of-care Treatment Trial Trial registration ventilator-free day Ventilator-free days with COVID-19 World Health Organization
[DOI] 10.1503/cmaj.211698 PMC 바로가기 [Article Type] Randomized Controlled Trial

Animated, video entertainment-education to improve vaccine confidence globally during the COVID-19 pandemic: an online randomized controlled experiment with 24,000 participants

Randomized Controlled Trial

Published on 2022-02-192022-10-04
Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상,

Clinical Evidence Informing Treatment Guidelines on Repurposed Drugs for Hospitalized Patients During the Early COVID-19 Pandemic: Corticosteroids, Anticoagulants, (Hydroxy)chloroquine

초기 CovID-19 Pandemic 동안 입원 환자를위한 용도로 된 약물에 대한 치료 지침에 대한 임상 증거 : 코르티코 스테로이드, 항응고제, (Hydroxy) 클로로퀸

Review

Published on 2022-02-182022-08-31
Journal: Frontiers in Public Health [Category] COVID19(2023년), meta-analysis, SARS, 임상,

[키워드] adoption Analysis Anticoagulants best Chloroquine clinical Clinical data clinical evidence Clinical studies clinical study clinical trials Coagulopathy competing conducted coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 drug Efficacy and safety evaluated Evidence evidence generation Factor Factors Germany guideline Health Organization hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hydroxy identify incorporation Inflammation Informing International meta-analyses Meta-analysis MOST National national treatment observational studies pandemic Patient care platform Platform trial platform trials protocol provided question randomized clinical trial RCT RCTs recommendations referred to Repurposed drug Repurposed drugs researcher Result retrospective cohort retrospective cohort study robust scientific rigor severely ill patient severely ill patients Spread Treatment treatment guideline treatment guidelines trials United State United States Viral viral replication WHO World Health Organization
[DOI] 10.3389/fpubh.2022.804404 PMC 바로가기 [Article Type] Review

Adverse Events Reporting Quality of Randomized Controlled Trials of COVID-19 Vaccine Using the CONSORT Criteria for Reporting Harms: A Systematic Review

Review

Published on 2022-02-172022-10-28
Journal: Vaccines [Category] COVID-19,

Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials

바이러스성 급성 호흡기 감염 치료를 위한 플라보노이드: 30건의 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2022-02-162022-09-11
Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 임상,

[키워드] achievement acute bronchitis acute respiratory tract infection adverse event adverse events Adverse reaction Adverse reactions alleviation alleviation of symptoms analyzed bronchial pneumonia bronchitis BSS changes in clearance common cold complementary and alternative medicine control group Controlled Controlled trial controlled trials COVID-19 duration of illness Efficacy analyses efficacy analysis Efficacy and safety eligible flavonoid flavonoids Hospitalization ICU Identifier incidence infections Influenza intensity limitations mechanical ventilation meta-analyses Meta-analysis Mortality not differ oxygen Patient patients hospitalized performed positive RCT RCTs respiratory respiratory tract infection Respiratory tract infections Result review rhinosinusitis RT-PCR Safe Safety severity sinusitis subject substantial risk suggested Symptom Symptoms systematic review TNF-α tonsillitis tonsillopharyngitis tract treating trials TSS Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upper respiratory tract upper respiratory tract infections Viral
[DOI] 10.3389/fpubh.2022.814669 PMC 바로가기 [Article Type] Meta-Analysis