Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-196가지 일반적인 암에서 ACE2 및 TMPRSS2의 유전적 감수성과 COVID-19에 대한 가능한 영향Article Published on 2021-07-012022-09-11 Journal: Cancer research and treatment [Category] SARS, 변종, [키워드] ACE2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological function Biological functions Cancer Colon Colorectal cancer common control sample controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient death demonstrated expression expression level expression levels expressions Gene Expression hazard ratio Hepatocellular carcinoma Impact increased risk Infection information invasive Invasive carcinoma investigated liver lung adenocarcinoma lung cancer material Neoplasms overexpression pandemic pathway Patients with cancer Precaution Prognosis Prostate reduced risk Serine significantly higher Spread Stage stomach cancer survival tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumor tumors upregulation [DOI] 10.4143/crt.2020.950 PMC 바로가기 [Article Type] Article
Greenspace exposure and COVID-19 mortality in the United States: January–July 2020Research article Published on 2021-07-012022-10-05 Journal: Environmental research [Category] SARS, 유전자 메커니즘, [키워드] adjusted Americans Analysis Area Aside association average black center characterized contribute COVID-19 COVID-19 mortality decile determine disease Engineering environmental factor evaluate imaging Immunity increased risk Increasing index Johns Hopkins University LAI leaf linear mixed model Medicaid MODIS Mortality Native Novel coronavirus objective Older age older population Physical inactivity Prevalence promote PROTECT reduced risk Resolution Respiratory health Result risk SARS-CoV-2 Science significantly susceptibility System The United States United State with COVID-19 [DOI] 10.1016/j.envres.2021.111195 [Article Type] Research article
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infectionResearch Article Published on 2021-06-302022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] Activation Affect Antiviral antiviral signaling biochemical Blood Caco2 cells Case series CCL-2 cellular Concentration contribute COVID-19 CPE, cytopathic effect cytokine release Cytokine release syndrome death driver DSF, dynamic scanning fluorimetry eosinophils explain expressed expression expression level Famotidine FRET, fluorescence resonance energy transfer functional GERD, gastroesophageal reflux disease H2 receptor Histamine IL6 Inflammation inflammatory mediator Inflammatory responses inflammatory signaling inhibit intubation IRF3 management Mast cells MC, mast cell molecular basis Neutrophils NF-κB pathway observation outcome PAMP, Pathogen-Associated Molecular Pattern patients hospitalized patients with COVID-19 pharmacokinetic PKA, protein kinase A precipitate Protease activity reduce reduced reduced risk retrospective cohort SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection SARS-CoV-2-infected cell SARSCoV-2, severe acute respiratory syndrome coronavirus 2 Signaling symptom resolution TLR3 TLR3, toll-like receptor 3 Toll-like receptor Toll-like receptor 3 treated Treatment Vaccinations viral replication with COVID-19 [DOI] 10.1016/j.jbc.2021.100925 PMC 바로가기 [Article Type] Research Article
Managing diabetes in diabetic patients with COVID: where do we start from?Review Article Published on 2021-06-252022-10-28 Journal: Acta Diabetologica [Category] COVID-19, MERS, SARS, [키워드] affected appear article COVID-19 determine diabete Diabetes Mellitus Diabetes treatment diabetic patient driven by drug drugs Evidence excluded increased risk insulin managing Meta-analysis metformin Mortality national health system Neutral outcome Patient performed phenotype receive reduce reduced risk Result retrospective risk SARS-CoV-2 Treatment Type 2 [DOI] 10.1007/s00592-021-01739-1 PMC 바로가기 [Article Type] Review Article
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical GuidelinesCOVID-19 감염 예방 및 치료를 위한 Ivermectin: 임상 지침을 제공하기 위한 체계적인 검토, 메타 분석 및 시험 순차 분석Meta-Analysis Published on 2021-06-212022-09-11 Journal: American journal of therapeutics [Category] SARS, 치료제, [키워드] 95% confidence interval adverse event Analysis anti-inflammatory properties antiparasitic Antiviral approach Area average average risk benefit certainty Chemoprophylaxis clinical Clinical course clinical trials conducted COVID-19 COVID-19 infection database death Deterioration Efficacy estimate Evidence evidence of guideline high risk Inclusion Ivermectin ivermectin treatment less mechanical ventilation Medicine meta-analyses Meta-analysis Mortality no difference outcome pandemic participant prevention Prophylaxis provided Randomized controlled trial reduce reduced reduced risk reducing mortality reductions in review Risk of bias risk ratio robust SARS-CoV-2 pandemic SARS-CoV-2 virus searched secondary secondary outcome Secondary outcomes sequential analysis severe adverse events severe disease suggested tested the SARS-CoV-2 the SARS-CoV-2 virus treatment trial treatment trials Trial trial sequential analyses trial sequential analysis [DOI] 10.1097/MJT.0000000000001402 PMC 바로가기 [Article Type] Meta-Analysis
Association of social distancing and face mask use with risk of COVID-19Article Published on 2021-06-182022-10-04 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] association cohort study Community COVID-19 COVID-19 symptoms COVID-19 transmission Effectiveness Efficacy effort Epidemiology examined Face mask individual Lifestyle modification lower risk measure mitigate Participants predicted reduced risk reducing risk Risk factors risk of COVID-19 SARS-CoV-2 social distancing Social distancing measure spread of COVID-19 Support Symptom unmet need used data vaccination viral infection [DOI] 10.1038/s41467-021-24115-7 PMC 바로가기 [Article Type] Article
Chronic anticoagulation is not associated with a reduced risk of acute kidney injury in hospitalised Covid-19 patientsResearch Published on 2021-06-162022-10-28 Journal: BMC Nephrology [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury acute renal failure Admission AKI Anticoagulant anticoagulant therapy anticoagulation chronic COVID-19 criteria determine diagnosis of COVID-19 disease Factor foundation global pandemic group hospitalised hypercoagulable hypertension incidence intensive care unit KDIGO Kidney disease less Male sex mechanical ventilation Mortality no difference occur outcome Patient patients with COVID-19 randomised controlled study receive reduced reduced risk renal renal replacement therapy Respiratory failure Result SARS-CoV2 severity supplementary material therapy thrombosis thrombotic Treatment Trust university unlikely were excluded World Health Organisation [DOI] 10.1186/s12882-021-02436-5 PMC 바로가기 [Article Type] Research
Worldviews, trust, and risk perceptions shape public acceptance of COVID-19 public health measuresClinical Trial Published on 2021-06-152022-10-05 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 임상, [키워드] conducted country COVID-19 declined declines driver epidemiological Factor Health less measure Measures number of infected opposite outbreak Perceived risk public health measure reduced reduced risk reducing reduction in risk Risk perception Support Switzerland Trust variables worldviews. [DOI] 10.1073/pnas.2100411118 PMC 바로가기 [Article Type] Clinical Trial
COVID-19: Seroprevalence and Vaccine Responses in UK Dental Care ProfessionalsCOVID-19: 영국 치과 진료 전문가의 혈청 유병률 및 백신 반응Research Reports Published on 2021-06-022022-09-10 Journal: Journal of Dental Research [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti–SARS-CoV-2 IgG antibodies antibody Antibody Response Antibody responses baseline Care Cohort coronavirus coronavirus disease Coronavirus disease 2019 DCPs dental dentistry Deprivation detectable enzyme-linked immunosorbent enzyme-linked immunosorbent assay estimate exposure to First wave Follow-up future infection greater Guidance health guidance Health Organization Immunological memory individual Infection Infection prevention infection with SARS-CoV-2 initial International international standard leads magnitude natural natural infection occupational exposure occurred pandemic participant Personal protective equipment Pfizer-BioNTech polymerase chain polymerase chain reaction PPE professional public health recruited reduced risk respiratory response retained risk robust SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 spike glycoprotein second wave seroepidemiological studies serological response seropositive Seropositivity Seroprevalence severe acute respiratory syndrome Coronavirus significantly higher single dose spike glycoprotein Support thought United Kingdom vaccination Vaccine was determined West World Health Organization [DOI] 10.1177/00220345211020270 PMC 바로가기 [Article Type] Research Reports
Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study중증 COVID-19 폐렴 및 중등도 과염증 환자에서 코르티코스테로이드 단독 또는 토실리주맙 치료 후 아나킨라. 후향적 코호트 연구Observational Study Published on 2021-06-012022-09-12 Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단, [키워드] 95% CI according to protocol adjusted hazard ratio Admission age Anakinra analyzed appear carried CD4 Characteristics clinical Clinical course Clinical severity Corticosteroid corticosteroid pulse COVID-19 Cytokine storm syndrome death died Evidence hyperinflammation hyperinflammatory state IMPROVE infectious complication Infectious complications intensive care Laboratory management Methylprednisolone moderate Mortality Observational cohort study Patient patients with moderate Prognosis pulse receiving receptor reduced risk retrospective retrospective cohort study Severe COVID-19 pneumonia Standard therapy Tocilizumab tocilizumab therapy Treatment treatment with anakinra [DOI] 10.1007/s11739-020-02600-z PMC 바로가기 [Article Type] Observational Study