DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster ModelSARS-CoV-2 스파이크-CD40L 융합 단백질을 발현하는 DNA 기반 백신은 시리아 햄스터 모델에서 공격에 대한 보호를 제공합니다Immunology Published on 2022-01-122022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] Against Antibody Response boost CD40 ligand CD40L challenge coronavirus demonstrated Diseases DNA DNA vaccine effective Efficacy Efficacy and safety form fused fusion globe hamster Heterologous immune responses infections Intramuscular injection less Ligand lung Lung pathology Model molecular nasal turbinate neutralizing antibody pathology protection public health reduce reduced regimen reported safety profile SARS-CoV-2 SARS-COV-2 infection shown Spike protein storage conditions suppressed the SARS-CoV-2 the vaccine vaccination Vaccine variety viral replication weight loss [DOI] 10.3389/fimmu.2021.785349 PMC 바로가기 [Article Type] Immunology
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19COVID-19로 입원한 성인을 대상으로 한 플리티뎁신의 전임상 및 무작위 1상 연구Clinical Trial Published on 2022-01-102022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, 비임상, 신약개발, 임상, [키워드] adults hospitalized adverse event adverse events affecting baseline breath Concentration conducted Consent diarrhea died dose elongation factor End points eukaryotic translation grade 3 hospital hospitalized patient host protein hypersensitivity inhibit initiated intensive care intensive care support invasive ventilation log lung Mortality nausea once daily one patient Open-label Patient patients with COVID-19 peptide Phase I plasma Plitidepsin Preclinical preclinical studies Randomized required respiratory Respiratory Support safety profile SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variant Spanish Support Treatment Viral Viral load viral load reduction vomiting with COVID-19 [DOI] 10.26508/lsa.202101200 PMC 바로가기 [Article Type] Clinical Trial
Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-AnalysisArticle Published on 2022-01-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% confidence interval anti-SARS-CoV-2 vaccine Antibody Response antibody response rate appear COVID-19 COVID-19 vaccine demonstrated dose Efficacy Efficacy and safety evaluated inclusion criteria linear mRNA vaccine occurred Patient patients performed proportion Random-effects models Randomized controlled trial recipient recipients reduced reported retrospective review Safe Safety safety profile second dose serologic seronegative severe adverse event Solid solid organ solid organ transplant Solid organ transplant recipients systemic the SARS-CoV-2 third dose Transplant Vaccine vaccine dose Vaccines Web of Science [DOI] 10.3390/vaccines10010095 PMC 바로가기 [Article Type] Article
Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database입원 COVID-19 환자에서 Remdesivir의 안전 및 임상 결과 : 활발한 감시 데이터베이스의 후 향적 분석Research Article Published on 2022-01-042022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 치료제, [키워드] Active surveillance Administered adverse event Analysis Antibiotics cardiac disease Clinical outcome clinical status Comorbidities concomitant medications conducted COVID-19 Data analysis Data collection database diabete diabetes died Factor High-flow oxygen hospitalised hospitalised patient Hospitalised patients hypertension increased liver enzyme increased liver enzymes India liver enzymes low-flow oxygen management mechanical ventilation men Mortality mortality rate nausea nausea and vomiting non-invasive ventilation oxygen Oxygen therapy Patient patients receiving Remdesivir Result Retrospective analysis Retrospective studies Safety safety profile significantly higher significantly lower steroid Steroids Subgroup analyses subgroup analysis supplementary material treatment for COVID-19 used data vomiting with COVID-19 [DOI] 10.1186/s12879-021-07004-8 PMC 바로가기 [Article Type] Research Article
mRNA vaccines against COVID-19: a showcase for the importance of microbial biotechnologyCOVID-19에 대한 mRNA 백신: 미생물 생명공학의 중요성에 대한 쇼케이스Article Published on 2022-01-012022-09-11 Journal: Microbial Biotechnology [Category] SARS, 변종, [키워드] Adverse reaction Adverse reactions Alpha Beta variant booster chills Coverage COVID-19 CureVac delta variant Delta variants Efficacy Extensive Facial nerve facial nerve paralysis fatigue Fever Formulation group headache increase in Infection injection injection site pain lipid composition male microbial Mild Moderna mRNA mRNA vaccine mRNA vaccines muscle pain myocarditis nanoparticle nerve paralysis neutralization observational studies observational study Older Pain Pfizer-BioNTech phase Population pseudouridine replacement risk safety profile SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein severe COVID-19 Spike protein subject Surveillance symptomatic disease the SARS-CoV-2 uridine Vaccine vaccine trial variant viruses [DOI] 10.1111/1751-7915.13974 PMC 바로가기 [Article Type] Article
COVID-19 and vaccination against SARS-CoV-2 in patients with neuromyelitis optica spectrum disordersResearch article Published on 2022-01-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] SARS, 진단, [키워드] adverse effect adverse events Belgrade case fatality ratio clinic Clinical characteristics clinical manifestation Cohort COVID COVID-19 COVID-19 in patient COVID-19 vaccine diagnosed with COVID-19 Diagnostic Criteria died disorder dose EDSS enrolled Hospitalization Hospitalized indicate information Invasive mechanical ventilation NEUROLOGY NMOSD outcome Patient patients Pfizer Pneumonia Prospective report requiring supplemental oxygen Result safety profile SARS-CoV-2 severity severity of COVID-19 Sinopharm the vaccine These data vaccination Vaccine [DOI] 10.1016/j.msard.2021.103320 [Article Type] Research article
Safety and immunogenicity of a measles-vectored SARS-CoV-2 vaccine candidate, V591 / TMV-083, in healthy adults: results of a randomized, placebo-controlled Phase I study건강한 성인에서 홍역 매개 SARS-CoV-2 백신 후보 V591/TMV-083의 안전성 및 면역원성: 무작위, 위약 대조 1상 연구 결과Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] SARS, 임상, 치료기술, [키워드] adverse event adverse events age antibodies antibody Belgium binding antibodies Bioscience CEPI Chikungunya Coalition cohorts COVID-19 detectable dose Dose escalation double-blind evaluate expressing France healthy High dose high dose vaccine immune response Immunity immunogenicity Inc. injection Injections Innovation Intramuscular injection low dose low dose vaccine measles vector median Neutralizing antibodies neutralizing antibody participant performed phase Placebo placebo recipients placebo-controlled pre-fusion Randomized receiving reported responses Safety safety profile SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine screened Serious Adverse Event Serious Adverse Events Spike protein spike-specific T cell statistically significant subsidiary Support T cell T cell response T cell responses TCID THEMIS tissue culture treatment phase Trial Vaccine vaccine candidate vaccinee Volunteer was measured while [DOI] 10.1016/j.ebiom.2021.103810 PMC 바로가기 [Article Type] Clinical Trial
Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challengesReviews Published on 2021-12-312022-10-30 Journal: Intensive Care Medicine Experimental [Category] COVID-19, [키워드] acute hypoxic respiratory failure acute respiratory distress syndrome added aetiology Anti-viral therapy attenuate Cell Cell therapy Cell-based therapy cellular Clinical studies clinical study coronavirus COVID-19 pandemic Critical illness demonstrated early phase Endemic ENhance Epidemiology globe in vivo Influenza investigated Lung injury management Mesenchymal stem cells morbidity and mortality MSC MSCs outbreak pandemic Pandemics Pneumonia receiving safety profile Sepsis severe viral pneumonia supplementary material therapeutic approaches therapeutic potential therapeutic strategy therapy these cell These cells tissue translation Trial urgency viral epidemics Viral pneumonia viruses while [DOI] 10.1186/s40635-021-00424-5 PMC 바로가기 [Article Type] Reviews
Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2Case Report Published on 2021-12-282022-10-28 Journal: BMC Rheumatology [Category] COVID-19, [키워드] activate Activation Adult-onset Still’s disease adverse events Autoimmune BNT162b2 Case report ChAdOx1 nCoV-19 Complication conditions COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines described disease dose female ferritin level immune cells Influenza interferon knowledge macrophage activation syndrome MONITOR mortality rate mRNA mRNA vaccine nucleic acid Occurrence of BNT162b2 pathogen-associated molecular pattern Patient positive potentially life-threatening pro-inflammatory cytokine receiving safety profile SARS-CoV-2 vaccination shown supplementary material syndrome thought Toll-like receptor vaccination Vaccine reaction viral infection Viral vector vaccine [DOI] 10.1186/s41927-021-00237-9 PMC 바로가기 [Article Type] Case Report
Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infectionArticle Published on 2021-12-242022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract approved astrocytes calu-3 cells Cell Biology cell entry cellular entry Chemistry Compound COVID-19 COVID-19 outbreak entry of SARS-CoV-2 global public health HEK293T cells human cell human cells human lung identify Infection inhibit inhibitor inhibitors of SARS-CoV-2 Neuron non-toxic Pandemics Prevent pseudotyped pseudotyped SARS-CoV-2 Q34 related virus safety profile SARS-CoV-2 SARS-COV-2 infection screened small molecule Toxicity treated uninfected cell Virology [DOI] 10.1016/j.isci.2021.103684 PMC 바로가기 [Article Type] Article