Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samplesArticle Published on 2022-10-262022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 3CLpro acute respiratory syndrome applicability approach Asymptomatic individuals carried caused clinical test coronavirus death detect enzymatic activity enzyme Infection marker PCR testing pH indicator platform point-of-care proteolytic proteolytic activity reliability Saliva SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity subject Transmission Viral transmission [DOI] 10.1038/s41467-022-34074-2 PMC 바로가기
New insights into SARS-CoV-2 Lumipulse G salivary antigen testing: accuracy, safety and short TAT enhance surveillanceSARS-CoV-2 루미펄스 G 타액 항원 검사에 대한 새로운 통찰: 정확성, 안전성 및 짧은 TAT가 감시를 강화합니다.Article Published on 2022-10-262023-07-10 Journal: Clinical chemistry and laboratory medicine [Category] COVID19(2023년), [키워드] chemiluminescence (CLEIA) Lumipulse N-antigen Saliva SARS-CoV-2 [DOI] 10.1515/cclm-2022-0849
Comparison of SARS-CoV-2 Detection from Saliva Sampling and Oropharyngeal SwabArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome addition analyzed buffer Care clinics Cohort collected Community comparable coronavirus COVID-19 COVID-19 pandemic detection detection rate effective ENhance examined feasible flexible Health Large-scale testing lockdowns Oropharyngeal oropharyngeal swab pandemic performed positive reduce resource reverse transcription-PCR RNA RNA stability RT-PCR RT-qPCR Saliva sampling SARS-CoV-2 SARS-CoV-2 detection Schools screening method sensitivity Sensitivity and specificity specificity stability subject subjects Swab swabbing symptomatic and asymptomatic temperature Viral RNA was used [DOI] 10.1128/spectrum.01422-22 PMC 바로가기
A Rapid SARS-CoV-2 Nucleocapsid Protein Profiling Assay with High Sensitivity Comparable to Nucleic Acid DetectionArticle Published on 2022-10-252022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acid Antigen binding caused Concentration COVID-19 COVID-19 diagnosis detection DNA effective ELISA kits Epidemic Epidemics information limit of detection magnitude N protein nucleic acid nucleocapsid protein PCR Profiling Protein Rapid Region resulting Saliva SARS-CoV-2 sensitivity target protein The fluorescence intensity the N protein translation [DOI] 10.1021/acs.analchem.2c02670 PMC 바로가기
Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing: cross-sectional studyArticle Published on 2022-10-242022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Accuracy Ag-RDT Ag-RDTs analyses Antigen antigen detection antigen test asymptomatic individual COVID-19 cross-sectional cross-sectional study cut-off diagnostic Diagnostic accuracy diagnostic test Diagnostic test accuracy E-gene General population individual Interpretation molecular molecular test MOST nasal Nasal test Negative predictive value participant Participants positive Positive predictive value presenting public health Rapid rapid antigen detection test Roche Diagnostics Saliva saliva test SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 testing SD Biosensor sensitivity subgroups Symptom symptomatic and asymptomatic Viral load [DOI] 10.1186/s12916-022-02603-x PMC 바로가기
Saliva metabolomic profile of COVID-19 patients associates with disease severityArticle Published on 2022-10-222022-11-15 Journal: Metabolomics [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-aminolevulinic acid Asymptomatic Biomarker Biomarkers C-reactive protein cellular change changes changes in Comparisons controls Coronavirus disease 2019 correlated COVID-19 COVID-19 group COVID-19 patient COVID-19 patients D-dimer diagnostic Disease progression disease severity dysregulation early stage expected Infection intensity Level liquid liquid chromatography-mass spectrometry metabolite metabolomic metabolomics Mild moderate molecular non-infected non-severe patients parameter Patient physiological plasma positively correlated profile prognostic prognostic biomarker risk Saliva SARS-CoV-2 screened severity significantly sphingosine stages utility were used [DOI] 10.1007/s11306-022-01936-1 PMC 바로가기
Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndromeArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] analyzed Anti-viral anti-viral antibody antibody Antibody Response baseline chronic disease CMV cohorts COVID-19 EBV elevated fatigue healthy donor herpesvirus herpesvirus reactivation HERV HERV-K HHV6A HSV2 IgG immunoassay latent virus majority ME/CFS mechanisms multiplex Myalgic encephalomyelitis/chronic fatigue syndrome nuclear oral mucosa overlap Patient plasma Post-viral fatigue Reactivation retrovirus risk factor Saliva SARS-COV-2 infection shown significantly sustained Symptom syndrome systemically triggered unique viral infection virus [DOI] 10.3389/fimmu.2022.949787 PMC 바로가기
Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2Article Published on 2022-10-182022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] antibody antibody production appear BNT162b2 BNT162b2 mRNA vaccine convalescent correlated COVID-19 COVID-19 patients decrease detectable eight elicit functional generate Heterologous humoral humoral immune response Immunity immunization increase induce marker mRNA vaccination mRNA vaccine mucosal mucosal immune NAb Neutralizing neutralizing capacity of BNT162b2 omicron peaked progression proportion protective immune response RBD RBD-binding antibody reduced Saliva SARS-CoV-2 second dose second vaccination sera significantly Spike protein subsequent the RBD the S1 subunit the SARS-CoV-2 vaccinated individual vaccination Vaccine vaccinee vaccinees variant virus neutralizing titers VoC VOCs wildtype [DOI] 10.1371/journal.pone.0263861 PMC 바로가기
Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionalsArticle Published on 2022-10-142022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy analyzed antibodies Antibody Response being Blood blood collection both group capillary capillary blood Clinical practice collected correlation coefficient COVID-19 COVID-19 vaccine criteria determine dose effective evaluate feasibility feasible flexible Health Immune-mediated inflammatory disease less majority NPs participant Patient patient groups professional promoter protocol recorded Remote care reported Safe Saliva SARS-CoV-2 antibody response SARS-CoV-2 vaccines self-collection Self-sampling significantly significantly higher Spearman SUS telehealth Usability vaccination Vaccination strategy Vaccine venous Wilcoxon signed-rank test [DOI] 10.3389/fpubh.2022.994770 PMC 바로가기
A fast, ultrasensitive SERS immunoassay to detect SARS-CoV-2 in salivaArticle Published on 2022-10-092022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] Alpha antibody Antigen Concentration COVID-19 COVID-19 pandemic detect Diagnosis diagnostics disease transmission E. coli expressed Genome immunoassay inactivated less MERS Omicron variants point-of-care qRT-PCR Raman spectroscopy recombinant Saliva SARS-CoV-2 SARS-CoV-2 spike proteins SARS-CoV-2 virus scattering scFv Single chain variable fragment (scFv) Spike protein Spike proteins surface-enhanced Raman scattering (SERS) tested the SARS-CoV-2 the SARS-CoV-2 virus [DOI] 10.1016/j.aca.2022.340290 PMC 바로가기